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- W2116730800 abstract "In recent years, cutaneous B-cell lymphoma (CBCL) has emerged as a clinicopathologic entity with a natural history distinct from nodal Non-Hodgkins lymphoma (NHL). However, given its rarity, population-based incidence and survival rates have not yet been documented, and single-institution reports have been unable consistently to identify prognostic factors and optimal treatment strategies. In a population-based cohort derived from the National Cancer Institute Surveillance, Epidemiology, and End Results (SEER) program, we identified all cases of B-cell NHL localized to the skin. Age-adjusted incidence rates of CBCL in the population, relative survival, and overall survival were calculated using standard methods. Significant clinical-pathologic predictors of overall survival were identified using multivariable Cox proportional hazards modelling. A total of 1,368 incident cases of CBCL were reported between 1973 and 2000. Since 1993, the age-adjusted incidence of CBCL has increased linearly with a slope of 8% per year (95% confidence interval (CI) 2%–15%), producing an age-adjusted incidence of 0.40 cases per 100,000 in the year 2000, compared with an age-adjusted incidence of 0.44 for mycosis fungoides and 17.8 for NHL. With a mean follow up time of 5.2 years, calculated five-year relative survival was 80%. Five-year relative survival was 47% for CBCL of the legs compared with 92% for head and neck skin site. In addition, five-year relative survival was 72% for large cell CBCL compared with 94% for follicular CBCL. Factors significantly predictive of poor overall survival in a multivariable model are presented in the attached table(table 1). CBCL accounts for 2% of all NHL and its incidence has increased sharply since 1993, approaching the frequency of mycosis fungoides. Patients with involvement of the legs, large cell histology, and advanced stage are at increased risk for poor outcome, and may benefit from aggressive therapy that includes radiation. Those patients with positive prognostic factors, who are conventionally treated with radiotherapy alone, experience excellent survival." @default.
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- W2116730800 date "2004-09-01" @default.
- W2116730800 modified "2023-09-26" @default.
- W2116730800 title "Cutaneous B-cell lymphoma: An emerging clinical entity" @default.
- W2116730800 doi "https://doi.org/10.1016/j.ijrobp.2004.06.175" @default.
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