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- W2116731443 abstract "Bronchial hyperresponsiveness is generally assessed by testing with methacholine (MCh) or histamine. Another possible stimulus with which to measure bronchial hyperresponsiveness is adenosine 5′-monophosphate (AMP). We have demonstrated previously 1 van den Berge M Meijer RJ Kerstjens HA et al. PC20adenosine 5′-monophosphate is more closely associated with airway inflammation in asthma than PC20methacholine. Am J Respir Crit Care Med. 2001; 163: 1546-1550 Crossref PubMed Scopus (211) Google Scholar that the provocative concentration of a substance (ie, AMP) causing a 20% fall in FEV1 (PC20) better reflects airway inflammation in asthma patients than does the MCh PC20. AMP, and by implication adenosine, acts by the release of a variety of inflammatory mediators from mast cells. We intended to assess with the study whether this AMP-induced mediator release initiates an inflammatory process resulting in the recruitment of eosinophils to the airways." @default.
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- W2116731443 date "2003-03-01" @default.
- W2116731443 modified "2023-10-06" @default.
- W2116731443 title "Provocation With Adenosine 5′-Monophosphate Increases Sputum Eosinophils" @default.
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- W2116731443 doi "https://doi.org/10.1378/chest.123.3_suppl.417s-a" @default.
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