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• W2116734310 abstract "ABSTRACT New drugs and molecular targets are needed against Trypanosoma brucei , the protozoan that causes African sleeping sickness. Tryptanthrin (indolo[2,1-b]quinazoline-6,12-dione), a traditional antifungal agent, and 11 analogs were tested against T. brucei in vitro. The greatest activity was conferred by electron-withdrawing groups in the 8 position of the tryptanthrin ring system; the most potent compound had a 50% effective concentration of 0.40 μM." @default.
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• W2116734310 date "2002-03-01" @default.
• W2116734310 modified "2023-10-18" @default.
• W2116734310 title "Antitrypanosomal Activities of Tryptanthrins" @default.
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• W2116734310 doi "https://doi.org/10.1128/aac.46.3.882-883.2002" @default.
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