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• W2116734905 abstract "Within the vertebrate groups, only mammals are subject to a specialized epigenetic process termed genomic imprinting in which genes are preferentially expressed from one parental allele. Imprinted expression has been reported for >100 mouse genes and, for approximately one-quarter of these genes, the imprinted expression is specific to the placenta (or extraembryonic tissues). This seemingly placenta-specific imprinted expression has garnered much attention, as has the apparent lack of conserved imprinting between the human and mouse placenta. In this study, we used a novel approach to re-investigate the placenta-specific expression using embryo transfer and trophoblast stem cells. We analyzed 20 genes previously reported to show maternal allele-specific expression in the placenta, and only 8 genes were confirmed to be imprinted. Other genes were likely to be falsely identified as imprinted due to their relatively high expression in contaminating maternal cells. Next, we performed a genome-wide transcriptome assay and identified 133 and 955 candidate imprinted genes with paternal allele- and maternal allele-specific expression. Of those we analyzed in detail, 1/6 (Gab1) of the candidates for paternal allele-specific expression and only 1/269 (Ano1) candidates for maternal allele-specific expression were authentically imprinted genes. Imprinting of Ano1 and Gab1 was specific to the placenta and neither gene displayed allele-specific promoter DNA methylation. Imprinting of ANO1, but not GAB1, was conserved in the human placenta. Our findings impose a considerable revision of the current views of placental imprinting." @default.
• W2116734905 created "2016-06-24" @default.
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• W2116734905 date "2011-10-24" @default.
• W2116734905 modified "2023-09-30" @default.
• W2116734905 title "Re-investigation and RNA sequencing-based identification of genes with placenta-specific imprinted expression" @default.
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• W2116734905 doi "https://doi.org/10.1093/hmg/ddr488" @default.
• W2116734905 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22025075" @default.
• W2116734905 hasPublicationYear "2011" @default.
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