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- W2116735451 abstract "In December of last year the Nobel Prize for Medicine or Physiology was awarded to the natural scientists N. K. Jerne, C. Milstein, and G. Köhler. These three immunologists have contributed fundamentally to our understanding of antibody synthesis by the individual immune cell. They confirmed the rule, established in the sixties, that only one antibody comes from each type of immune cell, thus giving it the status of a dogma. Jerne worked out the basic understanding of the great variety of antibodies, and his Jerne-Plaque-Test (1963) has enabled us to describe and analyze a single antibody-producing immune cell in vitro. Thus, the study of immune cell interaction and the cooperation of lymphocyte subpopulations, which leads to the formation of antibodies, received decisive impulses and important methodological prerequisites. In 1975 Köhler and Milstein succeeded in permanently stabilizing, i.e., immortalizing, the antibody production of an already immunologically specifically primed mortal immune cell by means of cell fusion (hybridization) with an immortal, cancerous immune cell (myeloma cell). The hybrid cell and the hybrid cell clone grown from it in cell culture produced a homogeneous antibody, having the desired constant binding specificity, in a practically unlimited fashion and independently of an animal organism, a monoclonal antibody. This scientific breakthrough was the beginning of a tremendously stimulating new biotechnological development, which very quickly spread to laboratories in diverse fields and which today enables us to take up, and in part even solve, scientific, technical, and medical problems that would otherwise not have been analyzable at present." @default.
- W2116735451 created "2016-06-24" @default.
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- W2116735451 date "1985-03-01" @default.
- W2116735451 modified "2023-09-26" @default.
- W2116735451 title "Monoclonal Antibodies: Their Chemistry, Functions, and Possible Uses" @default.
- W2116735451 cites W1459520148 @default.
- W2116735451 cites W1527896428 @default.
- W2116735451 cites W1537526970 @default.
- W2116735451 cites W1539015605 @default.
- W2116735451 cites W1777816980 @default.
- W2116735451 cites W1799861330 @default.
- W2116735451 cites W1801293486 @default.
- W2116735451 cites W1809771558 @default.
- W2116735451 cites W182038286 @default.
- W2116735451 cites W1887244640 @default.
- W2116735451 cites W1966585805 @default.
- W2116735451 cites W1967964620 @default.
- W2116735451 cites W1971362494 @default.
- W2116735451 cites W1973093126 @default.
- W2116735451 cites W1974242613 @default.
- W2116735451 cites W1975199388 @default.
- W2116735451 cites W1977100847 @default.
- W2116735451 cites W1977461031 @default.
- W2116735451 cites W1978482821 @default.
- W2116735451 cites W1980222948 @default.
- W2116735451 cites W1980711248 @default.
- W2116735451 cites W198145696 @default.
- W2116735451 cites W1982040395 @default.
- W2116735451 cites W1983562880 @default.
- W2116735451 cites W1983664030 @default.
- W2116735451 cites W1984452197 @default.
- W2116735451 cites W1989444902 @default.
- W2116735451 cites W1995639470 @default.
- W2116735451 cites W1996249519 @default.
- W2116735451 cites W1999770276 @default.
- W2116735451 cites W2001676232 @default.
- W2116735451 cites W2003593644 @default.
- W2116735451 cites W2004106131 @default.
- W2116735451 cites W2007018944 @default.
- W2116735451 cites W2011031046 @default.
- W2116735451 cites W2013521256 @default.
- W2116735451 cites W201659892 @default.
- W2116735451 cites W2021457023 @default.
- W2116735451 cites W2021998439 @default.
- W2116735451 cites W2022006319 @default.
- W2116735451 cites W2026029468 @default.
- W2116735451 cites W2027177009 @default.
- W2116735451 cites W2028652819 @default.
- W2116735451 cites W2030522563 @default.
- W2116735451 cites W2031928907 @default.
- W2116735451 cites W2034428077 @default.
- W2116735451 cites W2037568211 @default.
- W2116735451 cites W2040257444 @default.
- W2116735451 cites W2045490787 @default.
- W2116735451 cites W2048025181 @default.
- W2116735451 cites W2051625373 @default.
- W2116735451 cites W2053228535 @default.
- W2116735451 cites W2060469405 @default.
- W2116735451 cites W2065301634 @default.
- W2116735451 cites W2071249922 @default.
- W2116735451 cites W2075475003 @default.
- W2116735451 cites W2075508172 @default.
- W2116735451 cites W2075592513 @default.
- W2116735451 cites W2076328260 @default.
- W2116735451 cites W2081387980 @default.
- W2116735451 cites W2082336022 @default.
- W2116735451 cites W2083954280 @default.
- W2116735451 cites W2085326592 @default.
- W2116735451 cites W2087483761 @default.
- W2116735451 cites W2088559288 @default.
- W2116735451 cites W2095237197 @default.
- W2116735451 cites W2095319136 @default.
- W2116735451 cites W2096428903 @default.
- W2116735451 cites W2096649676 @default.
- W2116735451 cites W2098001605 @default.
- W2116735451 cites W2100410983 @default.
- W2116735451 cites W2102719470 @default.
- W2116735451 cites W2104518210 @default.
- W2116735451 cites W2106719152 @default.
- W2116735451 cites W2106867441 @default.
- W2116735451 cites W2107810107 @default.
- W2116735451 cites W2108391599 @default.
- W2116735451 cites W2109123846 @default.
- W2116735451 cites W2109289856 @default.
- W2116735451 cites W2111648475 @default.
- W2116735451 cites W2129839893 @default.
- W2116735451 cites W2130529027 @default.
- W2116735451 cites W2141155302 @default.
- W2116735451 cites W2141801114 @default.
- W2116735451 cites W2159087045 @default.