FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2116736766> ?p ?o ?g. }

• W2116736766 endingPage "1115" @default.
• W2116736766 startingPage "1107" @default.
• W2116736766 abstract "Abstract Objective: The goal of this investigation was to determine whether more aggressive vancomycin dosing is associated with greater risk for renal toxicity in patients with health care-associated pneumonia (HCAP) attributed to methicillin-resistant Staphylococcus aureus (MRSA). Methods: This was a retrospective, single-center, observational cohort study. The following information was obtained for all study patients from automated hospital, microbiology, and pharmacy databases: age, sex, weight, serial serum creatinine (SCr), age- and sex-adjusted creatinine clearance (CrCl) during receipt of vancomycin, vancomycin serum trough concentrations, duration of vancomycin therapy, and Acute Physiology and Chronic Health Evaluation II scores. Renal toxicity was defined as either a 0.5-mg/dL increase from baseline in SCr or a ≥50% increase in SCr based on serial SCr measurements. Data for patients who met the definition of renal toxicity were compared with data for those who did not. Results: Ninety-four patients (mean [SD]age, 59.0 [15.6] years; 59 [62.8%] men; 73 (77.7%) white; mean baseline CrCl, 70.3 [23.0] mL/min) were identified as having MRSA HCAP. Forty (42.6%) patients developed renal toxicity. Patients who developed renal toxicity were significantly more likely than patients who did not develop renal toxicity to have greater mean vancomycin serum trough concentrations (20.8 [9.9] g/mL vs 14.3 [6.7] g/mL, respectively; P < 0.001), vancomycin serum trough concentrations ≥15 g/mL (67.5% vs 40.7%; P = 0.01), and a prolonged duration (≥14 days) of vancomycin treatment (45.0% vs 20.4%; P = 0.011). Logistic regression analysis identified a maximum vancomycin serum trough concentration of ≥15 g/mL as being independently associated with renal toxicity (adjusted odds ratio = 2.82; 95% CI, 1.02–7.74; P = 0.045). The overall mean change in CrCl for the study population was −13.5 (−16.0) mL/min (range, 0.0 to −62.6 mL/min). Patients with maximum measured vancomycin serum trough concentrations ≥15 g/mL (n = 49) had significantly greater absolute changes in CrCl compared with patients with maximum measured vancomycin serum trough concentrations <15 g/mL (n = 45) (−18.9 [−17.0] vs −7.6 [−12.5] mL/min, respectively; P < 0.001). Conclusions: The results suggest that aggressive vancomycin dosing and prolonged vancomycin administration may be associated with greater risk for renal toxicity in patients with MRSA HCAP. However, this retrospective study cannot establish causation, and a prospective, randomized, double-blind trial is needed. Abstract The goal of this investigation was to determine whether more aggressive vancomycin dosing is associated with greater risk for renal toxicity in patients with health care-associated pneumonia (HCAP) attributed to methicillin-resistant Staphylococcus aureus (MRSA). This was a retrospective, single-center, observational cohort study. The following information was obtained for all study patients from automated hospital, microbiology, and pharmacy databases: age, sex, weight, serial serum creatinine (SCr), age- and sex-adjusted creatinine clearance (CrCl) during receipt of vancomycin, vancomycin serum trough concentrations, duration of vancomycin therapy, and Acute Physiology and Chronic Health Evaluation II scores. Renal toxicity was defined as either a 0.5-mg/dL increase from baseline in SCr or a ≥50% increase in SCr based on serial SCr measurements. Data for patients who met the definition of renal toxicity were compared with data for those who did not. Ninety-four patients (mean [SD]age, 59.0 [15.6] years; 59 [62.8%] men; 73 (77.7%) white; mean baseline CrCl, 70.3 [23.0] mL/min) were identified as having MRSA HCAP. Forty (42.6%) patients developed renal toxicity. Patients who developed renal toxicity were significantly more likely than patients who did not develop renal toxicity to have greater mean vancomycin serum trough concentrations (20.8 [9.9] g/mL vs 14.3 [6.7] g/mL, respectively; P < 0.001), vancomycin serum trough concentrations ≥15 g/mL (67.5% vs 40.7%; P = 0.01), and a prolonged duration (≥14 days) of vancomycin treatment (45.0% vs 20.4%; P = 0.011). Logistic regression analysis identified a maximum vancomycin serum trough concentration of ≥15 g/mL as being independently associated with renal toxicity (adjusted odds ratio = 2.82; 95% CI, 1.02–7.74; P = 0.045). The overall mean change in CrCl for the study population was −13.5 (−16.0) mL/min (range, 0.0 to −62.6 mL/min). Patients with maximum measured vancomycin serum trough concentrations ≥15 g/mL (n = 49) had significantly greater absolute changes in CrCl compared with patients with maximum measured vancomycin serum trough concentrations <15 g/mL (n = 45) (−18.9 [−17.0] vs −7.6 [−12.5] mL/min, respectively; P < 0.001). The results suggest that aggressive vancomycin dosing and prolonged vancomycin administration may be associated with greater risk for renal toxicity in patients with MRSA HCAP. However, this retrospective study cannot establish causation, and a prospective, randomized, double-blind trial is needed." @default.
• W2116736766 created "2016-06-24" @default.
• W2116736766 creator A5010331654 @default.
• W2116736766 creator A5012408148 @default.
• W2116736766 creator A5025825030 @default.
• W2116736766 creator A5026604447 @default.
• W2116736766 creator A5036949295 @default.
• W2116736766 date "2007-06-01" @default.
• W2116736766 modified "2023-10-18" @default.
• W2116736766 title "A retrospective analysis of possible renal toxicity associated with vancomycin in patients with health care-associated methicillin-resistant Staphylococcus aureus pneumonia" @default.
• W2116736766 cites W1543351452 @default.
• W2116736766 cites W1924960875 @default.
• W2116736766 cites W1996727820 @default.
• W2116736766 cites W2001604291 @default.
• W2116736766 cites W2017550678 @default.
• W2116736766 cites W2036129782 @default.
• W2116736766 cites W2044368480 @default.
• W2116736766 cites W2045761133 @default.
• W2116736766 cites W2056026648 @default.
• W2116736766 cites W2081117924 @default.
• W2116736766 cites W2083675153 @default.
• W2116736766 cites W2084817623 @default.
• W2116736766 cites W2094104004 @default.
• W2116736766 cites W2097559796 @default.
• W2116736766 cites W2114998899 @default.
• W2116736766 cites W2119142507 @default.
• W2116736766 cites W2126520713 @default.
• W2116736766 cites W2133923659 @default.
• W2116736766 cites W2134351049 @default.
• W2116736766 cites W2137631111 @default.
• W2116736766 cites W2144258933 @default.
• W2116736766 cites W2144504167 @default.
• W2116736766 cites W2144540367 @default.
• W2116736766 cites W4211194064 @default.
• W2116736766 cites W4229948769 @default.
• W2116736766 cites W4235600315 @default.
• W2116736766 cites W4242426124 @default.
• W2116736766 doi "https://doi.org/10.1016/j.clinthera.2007.06.014" @default.
• W2116736766 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17692725" @default.
• W2116736766 hasPublicationYear "2007" @default.
• W2116736766 type Work @default.
• W2116736766 sameAs 2116736766 @default.
• W2116736766 citedByCount "297" @default.
• W2116736766 countsByYear W21167367662012 @default.
• W2116736766 countsByYear W21167367662013 @default.
• W2116736766 countsByYear W21167367662014 @default.
• W2116736766 countsByYear W21167367662015 @default.
• W2116736766 countsByYear W21167367662016 @default.
• W2116736766 countsByYear W21167367662017 @default.
• W2116736766 countsByYear W21167367662018 @default.
• W2116736766 countsByYear W21167367662019 @default.
• W2116736766 countsByYear W21167367662020 @default.
• W2116736766 countsByYear W21167367662021 @default.
• W2116736766 countsByYear W21167367662022 @default.
• W2116736766 countsByYear W21167367662023 @default.
• W2116736766 crossrefType "journal-article" @default.
• W2116736766 hasAuthorship W2116736766A5010331654 @default.
• W2116736766 hasAuthorship W2116736766A5012408148 @default.
• W2116736766 hasAuthorship W2116736766A5025825030 @default.
• W2116736766 hasAuthorship W2116736766A5026604447 @default.
• W2116736766 hasAuthorship W2116736766A5036949295 @default.
• W2116736766 hasConcept C126322002 @default.
• W2116736766 hasConcept C141071460 @default.
• W2116736766 hasConcept C159641895 @default.
• W2116736766 hasConcept C167135981 @default.
• W2116736766 hasConcept C2777052132 @default.
• W2116736766 hasConcept C2777288759 @default.
• W2116736766 hasConcept C2777914695 @default.
• W2116736766 hasConcept C2778980435 @default.
• W2116736766 hasConcept C2779489039 @default.
• W2116736766 hasConcept C2780306776 @default.
• W2116736766 hasConcept C29730261 @default.
• W2116736766 hasConcept C523546767 @default.
• W2116736766 hasConcept C54355233 @default.
• W2116736766 hasConcept C71924100 @default.
• W2116736766 hasConcept C86803240 @default.
• W2116736766 hasConcept C90924648 @default.
• W2116736766 hasConceptScore W2116736766C126322002 @default.
• W2116736766 hasConceptScore W2116736766C141071460 @default.
• W2116736766 hasConceptScore W2116736766C159641895 @default.
• W2116736766 hasConceptScore W2116736766C167135981 @default.
• W2116736766 hasConceptScore W2116736766C2777052132 @default.
• W2116736766 hasConceptScore W2116736766C2777288759 @default.
• W2116736766 hasConceptScore W2116736766C2777914695 @default.
• W2116736766 hasConceptScore W2116736766C2778980435 @default.
• W2116736766 hasConceptScore W2116736766C2779489039 @default.
• W2116736766 hasConceptScore W2116736766C2780306776 @default.
• W2116736766 hasConceptScore W2116736766C29730261 @default.
• W2116736766 hasConceptScore W2116736766C523546767 @default.
• W2116736766 hasConceptScore W2116736766C54355233 @default.
• W2116736766 hasConceptScore W2116736766C71924100 @default.
• W2116736766 hasConceptScore W2116736766C86803240 @default.
• W2116736766 hasConceptScore W2116736766C90924648 @default.
• W2116736766 hasIssue "6" @default.
• W2116736766 hasLocation W21167367661 @default.
• W2116736766 hasLocation W21167367662 @default.
• W2116736766 hasOpenAccess W2116736766 @default.
• W2116736766 hasPrimaryLocation W21167367661 @default.

• next