Matches in SemOpenAlex for { <https://semopenalex.org/work/W2116737208> ?p ?o ?g. }
- W2116737208 endingPage "e52754" @default.
- W2116737208 startingPage "e52754" @default.
- W2116737208 abstract "It is known that cancer progresses by vertical gene transfer, but this paradigm ignores that DNA circulates in higher organisms and that it is biologically active upon its uptake by recipient cells. Here we confirm previous observations on the ability of cell-free DNA to induce in vitro cell transformation and tumorigenesis by treating NIH3T3 recipient murine cells with serum of colon cancer patients and supernatant of SW480 human cancer cells. Cell transformation and tumorigenesis of recipient cells did not occur if serum and supernatants were depleted of DNA. It is also demonstrated that horizontal cancer progression mediated by circulating DNA occurs via its uptake by recipient cells in an in vivo model where immunocompetent rats subjected to colon carcinogenesis with 1,2-dimethylhydrazine had increased rate of colonic tumors when injected in the dorsum with human SW480 colon carcinoma cells as a source of circulating oncogenic DNA, which could be offset by treating these animals with DNAse I and proteases. Though the contribution of biologically active molecules other than DNA for this phenomenon to occur cannot be ruled out, our results support the fact that cancer cells emit into the circulation biologically active DNA to foster tumor progression. Further exploration of the horizontal tumor progression phenomenon mediated by circulating DNA is clearly needed to determine whether its manipulation could have a role in cancer therapy." @default.
- W2116737208 created "2016-06-24" @default.
- W2116737208 creator A5004575782 @default.
- W2116737208 creator A5019773069 @default.
- W2116737208 creator A5022488513 @default.
- W2116737208 creator A5024725239 @default.
- W2116737208 creator A5026332396 @default.
- W2116737208 creator A5044720660 @default.
- W2116737208 creator A5047343521 @default.
- W2116737208 creator A5060564308 @default.
- W2116737208 creator A5070192692 @default.
- W2116737208 creator A5076338917 @default.
- W2116737208 creator A5077023411 @default.
- W2116737208 creator A5077188074 @default.
- W2116737208 creator A5085704029 @default.
- W2116737208 date "2012-12-28" @default.
- W2116737208 modified "2023-10-05" @default.
- W2116737208 title "Cancer Progression Mediated by Horizontal Gene Transfer in an In Vivo Model" @default.
- W2116737208 cites W1534367242 @default.
- W2116737208 cites W1875269331 @default.
- W2116737208 cites W1963853602 @default.
- W2116737208 cites W1966308841 @default.
- W2116737208 cites W1971992633 @default.
- W2116737208 cites W1984151197 @default.
- W2116737208 cites W1987237426 @default.
- W2116737208 cites W1994474089 @default.
- W2116737208 cites W2000789806 @default.
- W2116737208 cites W2003321071 @default.
- W2116737208 cites W2003980053 @default.
- W2116737208 cites W2005786362 @default.
- W2116737208 cites W2010232027 @default.
- W2116737208 cites W2029041799 @default.
- W2116737208 cites W2029861487 @default.
- W2116737208 cites W2036937248 @default.
- W2116737208 cites W2040294496 @default.
- W2116737208 cites W2051678321 @default.
- W2116737208 cites W2056436796 @default.
- W2116737208 cites W2057166751 @default.
- W2116737208 cites W2057320210 @default.
- W2116737208 cites W2058467341 @default.
- W2116737208 cites W2059175423 @default.
- W2116737208 cites W2070307875 @default.
- W2116737208 cites W2085169378 @default.
- W2116737208 cites W2090546008 @default.
- W2116737208 cites W2091852044 @default.
- W2116737208 cites W2094193861 @default.
- W2116737208 cites W2108296770 @default.
- W2116737208 cites W211157964 @default.
- W2116737208 cites W2114109904 @default.
- W2116737208 cites W2128137368 @default.
- W2116737208 cites W2148154572 @default.
- W2116737208 cites W2231747349 @default.
- W2116737208 cites W2531670180 @default.
- W2116737208 cites W3191711189 @default.
- W2116737208 doi "https://doi.org/10.1371/journal.pone.0052754" @default.
- W2116737208 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3532306" @default.
- W2116737208 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23285175" @default.
- W2116737208 hasPublicationYear "2012" @default.
- W2116737208 type Work @default.
- W2116737208 sameAs 2116737208 @default.
- W2116737208 citedByCount "101" @default.
- W2116737208 countsByYear W21167372082013 @default.
- W2116737208 countsByYear W21167372082014 @default.
- W2116737208 countsByYear W21167372082015 @default.
- W2116737208 countsByYear W21167372082016 @default.
- W2116737208 countsByYear W21167372082017 @default.
- W2116737208 countsByYear W21167372082018 @default.
- W2116737208 countsByYear W21167372082019 @default.
- W2116737208 countsByYear W21167372082020 @default.
- W2116737208 countsByYear W21167372082021 @default.
- W2116737208 countsByYear W21167372082022 @default.
- W2116737208 countsByYear W21167372082023 @default.
- W2116737208 crossrefType "journal-article" @default.
- W2116737208 hasAuthorship W2116737208A5004575782 @default.
- W2116737208 hasAuthorship W2116737208A5019773069 @default.
- W2116737208 hasAuthorship W2116737208A5022488513 @default.
- W2116737208 hasAuthorship W2116737208A5024725239 @default.
- W2116737208 hasAuthorship W2116737208A5026332396 @default.
- W2116737208 hasAuthorship W2116737208A5044720660 @default.
- W2116737208 hasAuthorship W2116737208A5047343521 @default.
- W2116737208 hasAuthorship W2116737208A5060564308 @default.
- W2116737208 hasAuthorship W2116737208A5070192692 @default.
- W2116737208 hasAuthorship W2116737208A5076338917 @default.
- W2116737208 hasAuthorship W2116737208A5077023411 @default.
- W2116737208 hasAuthorship W2116737208A5077188074 @default.
- W2116737208 hasAuthorship W2116737208A5085704029 @default.
- W2116737208 hasBestOaLocation W21167372081 @default.
- W2116737208 hasConcept C121608353 @default.
- W2116737208 hasConcept C207001950 @default.
- W2116737208 hasConcept C2993273003 @default.
- W2116737208 hasConcept C502942594 @default.
- W2116737208 hasConcept C526805850 @default.
- W2116737208 hasConcept C54355233 @default.
- W2116737208 hasConcept C552990157 @default.
- W2116737208 hasConcept C555283112 @default.
- W2116737208 hasConcept C86803240 @default.
- W2116737208 hasConcept C96232424 @default.
- W2116737208 hasConceptScore W2116737208C121608353 @default.