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• W2116738290 endingPage "4898" @default.
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• W2116738290 abstract "ABSTRACT The stringent response utilizes hyperphosphorylated guanine [(p)ppGpp] as a signaling molecule to control bacterial gene expression involved in long-term survival under starvation conditions. In gram-negative bacteria, (p)ppGpp is produced by the activity of the related RelA and SpoT proteins. Mycobacterium tuberculosis contains a single homolog of these proteins (Rel Mtb ) and responds to nutrient starvation by producing (p)ppGpp. A rel Mtb knockout strain was constructed in a virulent strain of M. tuberculosis , H37Rv, by allelic replacement. The rel Mtb mutant displayed a significantly slower aerobic growth rate than the wild type in synthetic liquid media, whether rich or minimal. The growth rate of the wild type was equivalent to that of the mutant when citrate or phospholipid was employed as the sole carbon source. These two organisms also showed identical growth rates within a human macrophage-like cell line. These results suggest that the in vivo carbon source does not represent a stressful condition for the bacilli, since it appears to be utilized in a similar Rel Mtb -independent manner. In vitro growth in liquid media represents a condition that benefits from Rel Mtb -mediated adaptation. Long-term survival of the rel Mtb mutant during in vitro starvation or nutrient run out in normal media was significantly impaired compared to that in the wild type. In addition, the mutant was significantly less able to survive extended anerobic incubation than the wild-type virulent organism. Thus, the Rel Mtb protein is required for long-term survival of pathogenic mycobacteria under starvation conditions." @default.
• W2116738290 created "2016-06-24" @default.
• W2116738290 creator A5003391183 @default.
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• W2116738290 creator A5072243737 @default.
• W2116738290 date "2000-09-01" @default.
• W2116738290 modified "2023-10-02" @default.
• W2116738290 title "The Stringent Response of <i>Mycobacterium tuberculosis</i> Is Required for Long-Term Survival" @default.
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• W2116738290 doi "https://doi.org/10.1128/jb.182.17.4889-4898.2000" @default.
• W2116738290 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/111369" @default.
• W2116738290 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10940033" @default.
• W2116738290 hasPublicationYear "2000" @default.
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