Matches in SemOpenAlex for { <https://semopenalex.org/work/W2116738383> ?p ?o ?g. }
- W2116738383 endingPage "91" @default.
- W2116738383 startingPage "85" @default.
- W2116738383 abstract "The involvement of K+ channels in the antinociceptive action of diclofenac was assessed in the formalin test. Local administration of diclofenac produced a dose-dependent antinociceptive effect due to a local action because drug administration in the contralateral paw was ineffective. Pretreatment of the injured paw with glibenclamide and tolbutamide (ATP-sensitive K+ channel inhibitors), charybdotoxin and apamin (large- and small-conductance Ca2+-activated K+ channel blockers, respectively), 4-aminopyridine or tetraethylammonium (voltage-dependent K+ channel inhibitors) prevented diclofenac-induced antinociception. Given alone, K+ channel inhibitors did not modify formalin-induced nociceptive behavior. Pinacidil (an ATP-sensitive K+ channel opener) also produced antinociception which was blocked by glibenclamide. The peripheral antinociceptive effect of morphine (positive control) was blocked by glibenclamide and 4-aminopyridine but not by charybdotoxin or apamin. The results suggest that the peripheral antinociceptive effect of diclofenac may result from the activation of several types of K+ channels, which may cause hyperpolarization of peripheral terminals of primary afferents." @default.
- W2116738383 created "2016-06-24" @default.
- W2116738383 creator A5027583078 @default.
- W2116738383 creator A5029224432 @default.
- W2116738383 creator A5042170623 @default.
- W2116738383 creator A5047344959 @default.
- W2116738383 creator A5063971484 @default.
- W2116738383 creator A5068478391 @default.
- W2116738383 date "2002-03-01" @default.
- W2116738383 modified "2023-10-17" @default.
- W2116738383 title "Pharmacological evidence for the activation of K+ channels by diclofenac" @default.
- W2116738383 cites W1965506226 @default.
- W2116738383 cites W1965665332 @default.
- W2116738383 cites W1969486060 @default.
- W2116738383 cites W1980001362 @default.
- W2116738383 cites W1987223426 @default.
- W2116738383 cites W1990739688 @default.
- W2116738383 cites W1992823328 @default.
- W2116738383 cites W1999307688 @default.
- W2116738383 cites W1999908521 @default.
- W2116738383 cites W2000818039 @default.
- W2116738383 cites W2011206723 @default.
- W2116738383 cites W2018983834 @default.
- W2116738383 cites W2029302344 @default.
- W2116738383 cites W2040709342 @default.
- W2116738383 cites W2043899013 @default.
- W2116738383 cites W2046152886 @default.
- W2116738383 cites W2057979763 @default.
- W2116738383 cites W2062600248 @default.
- W2116738383 cites W2066126003 @default.
- W2116738383 cites W2067877885 @default.
- W2116738383 cites W2067935663 @default.
- W2116738383 cites W2081370552 @default.
- W2116738383 cites W2082304034 @default.
- W2116738383 cites W2085032861 @default.
- W2116738383 cites W2087263689 @default.
- W2116738383 cites W2087454739 @default.
- W2116738383 cites W2092936332 @default.
- W2116738383 cites W2102041607 @default.
- W2116738383 cites W2116963442 @default.
- W2116738383 cites W2118688534 @default.
- W2116738383 cites W2120912313 @default.
- W2116738383 cites W2128466718 @default.
- W2116738383 cites W2140132685 @default.
- W2116738383 cites W2151482983 @default.
- W2116738383 doi "https://doi.org/10.1016/s0014-2999(02)01288-8" @default.
- W2116738383 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11906715" @default.
- W2116738383 hasPublicationYear "2002" @default.
- W2116738383 type Work @default.
- W2116738383 sameAs 2116738383 @default.
- W2116738383 citedByCount "105" @default.
- W2116738383 countsByYear W21167383832012 @default.
- W2116738383 countsByYear W21167383832013 @default.
- W2116738383 countsByYear W21167383832014 @default.
- W2116738383 countsByYear W21167383832015 @default.
- W2116738383 countsByYear W21167383832016 @default.
- W2116738383 countsByYear W21167383832017 @default.
- W2116738383 countsByYear W21167383832018 @default.
- W2116738383 countsByYear W21167383832019 @default.
- W2116738383 countsByYear W21167383832020 @default.
- W2116738383 countsByYear W21167383832021 @default.
- W2116738383 countsByYear W21167383832022 @default.
- W2116738383 countsByYear W21167383832023 @default.
- W2116738383 crossrefType "journal-article" @default.
- W2116738383 hasAuthorship W2116738383A5027583078 @default.
- W2116738383 hasAuthorship W2116738383A5029224432 @default.
- W2116738383 hasAuthorship W2116738383A5042170623 @default.
- W2116738383 hasAuthorship W2116738383A5047344959 @default.
- W2116738383 hasAuthorship W2116738383A5063971484 @default.
- W2116738383 hasAuthorship W2116738383A5068478391 @default.
- W2116738383 hasConcept C134018914 @default.
- W2116738383 hasConcept C153461711 @default.
- W2116738383 hasConcept C15490471 @default.
- W2116738383 hasConcept C170493617 @default.
- W2116738383 hasConcept C178790620 @default.
- W2116738383 hasConcept C181911157 @default.
- W2116738383 hasConcept C185592680 @default.
- W2116738383 hasConcept C2775984225 @default.
- W2116738383 hasConcept C2776054734 @default.
- W2116738383 hasConcept C2776919887 @default.
- W2116738383 hasConcept C2779768347 @default.
- W2116738383 hasConcept C2779826273 @default.
- W2116738383 hasConcept C2780419564 @default.
- W2116738383 hasConcept C2781295685 @default.
- W2116738383 hasConcept C517785266 @default.
- W2116738383 hasConcept C519063684 @default.
- W2116738383 hasConcept C55493867 @default.
- W2116738383 hasConcept C555293320 @default.
- W2116738383 hasConcept C71924100 @default.
- W2116738383 hasConcept C83743174 @default.
- W2116738383 hasConcept C98274493 @default.
- W2116738383 hasConceptScore W2116738383C134018914 @default.
- W2116738383 hasConceptScore W2116738383C153461711 @default.
- W2116738383 hasConceptScore W2116738383C15490471 @default.
- W2116738383 hasConceptScore W2116738383C170493617 @default.
- W2116738383 hasConceptScore W2116738383C178790620 @default.
- W2116738383 hasConceptScore W2116738383C181911157 @default.
- W2116738383 hasConceptScore W2116738383C185592680 @default.