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- W2116739490 abstract "Accumulation of fluid as ascites is the most common complication of cirrhosis. This is occurring in about 50% of patients within 10 years of the diagnosis of cirrhosis. It is a prognostic sign with 1-year and 5-year survival of 85% and 56%, respectively. The most acceptable theory for ascites formation is peripheral arterial vasodilation leading to underfilling of circulatory volume. This triggers the baroreceptor-mediated activation of renin-angiotensin-aldosterone system, sympathetic nervous system and nonosmotic release of vasopressin to restore circulatory integrity. The result is an avid sodium and water retention, identified as a preascitic state. This condition will evolve in overt fluid retention and ascites, as the liver disease progresses. Once ascites is present, most therapeutic modalities are directed on maintaining negative sodium balance, including salt restriction, bed rest and diuretics. Paracentesis and albumin infusion is applied to tense ascites. Transjugular intrahepatic portosystemic shunt is considered for refractory ascites. With worsening of liver disease, fluid retention is associated with other complications; such as spontaneous bacterial peritonitis. This is a primary infection of ascitic fluid caused by organisms originating from large intestinal normal flora. Diagnostic paracentesis and antibiotic therapy plus prophylactic regimen are mandatory. Hepatorenal syndrome is a state of functional renal failure in the setting of low cardiac output and impaired renal perfusion. Its management is based on drugs that restore normal renal blood flow through peripheral arterial and splanchnic vasoconstriction, renal vasodilation and/or plasma volume expansion. However, the definitive treatment is liver transplantation." @default.
- W2116739490 created "2016-06-24" @default.
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- W2116739490 creator A5090457083 @default.
- W2116739490 date "2008-01-09" @default.
- W2116739490 modified "2023-10-18" @default.
- W2116739490 title "Fluid retention in cirrhosis: pathophysiology and management" @default.
- W2116739490 cites W116131785 @default.
- W2116739490 cites W1469994996 @default.
- W2116739490 cites W1886401007 @default.
- W2116739490 cites W1936183830 @default.
- W2116739490 cites W1963977153 @default.
- W2116739490 cites W1964452095 @default.
- W2116739490 cites W1968717865 @default.
- W2116739490 cites W1979124801 @default.
- W2116739490 cites W1984180309 @default.
- W2116739490 cites W1985012829 @default.
- W2116739490 cites W1989051983 @default.
- W2116739490 cites W1989492547 @default.
- W2116739490 cites W1990415750 @default.
- W2116739490 cites W2001137775 @default.
- W2116739490 cites W2002271132 @default.
- W2116739490 cites W2005498263 @default.
- W2116739490 cites W2011199481 @default.
- W2116739490 cites W2012351418 @default.
- W2116739490 cites W2012654744 @default.
- W2116739490 cites W2012746560 @default.
- W2116739490 cites W2013027212 @default.
- W2116739490 cites W2015839847 @default.
- W2116739490 cites W2016111787 @default.
- W2116739490 cites W2020624820 @default.
- W2116739490 cites W2022088935 @default.
- W2116739490 cites W2022834873 @default.
- W2116739490 cites W2028289327 @default.
- W2116739490 cites W2031795011 @default.
- W2116739490 cites W203584926 @default.
- W2116739490 cites W2036408424 @default.
- W2116739490 cites W2038420606 @default.
- W2116739490 cites W2047951037 @default.
- W2116739490 cites W2049783764 @default.
- W2116739490 cites W2052276121 @default.
- W2116739490 cites W2053769824 @default.
- W2116739490 cites W2054641887 @default.
- W2116739490 cites W2057575003 @default.
- W2116739490 cites W2057793946 @default.
- W2116739490 cites W2061331348 @default.
- W2116739490 cites W2064429990 @default.
- W2116739490 cites W2064914299 @default.
- W2116739490 cites W2065000359 @default.
- W2116739490 cites W2065915308 @default.
- W2116739490 cites W2068821250 @default.
- W2116739490 cites W2071432305 @default.
- W2116739490 cites W2073024831 @default.
- W2116739490 cites W2075130658 @default.
- W2116739490 cites W2075178022 @default.
- W2116739490 cites W2078113157 @default.
- W2116739490 cites W2082020608 @default.
- W2116739490 cites W2086170643 @default.
- W2116739490 cites W2086478065 @default.
- W2116739490 cites W2087269435 @default.
- W2116739490 cites W2087450723 @default.
- W2116739490 cites W2089252944 @default.
- W2116739490 cites W2096782196 @default.
- W2116739490 cites W2097068257 @default.
- W2116739490 cites W2098005391 @default.
- W2116739490 cites W2103182875 @default.
- W2116739490 cites W2103472550 @default.
- W2116739490 cites W2105911415 @default.
- W2116739490 cites W2106227553 @default.
- W2116739490 cites W2108128920 @default.
- W2116739490 cites W2112007690 @default.
- W2116739490 cites W2114995548 @default.
- W2116739490 cites W2117294434 @default.
- W2116739490 cites W2117867130 @default.
- W2116739490 cites W2119995862 @default.
- W2116739490 cites W2120179295 @default.
- W2116739490 cites W2124334556 @default.
- W2116739490 cites W2131206408 @default.
- W2116739490 cites W2132058135 @default.
- W2116739490 cites W2134481878 @default.
- W2116739490 cites W2136528308 @default.
- W2116739490 cites W2142844479 @default.
- W2116739490 cites W2151039065 @default.
- W2116739490 cites W2157843987 @default.
- W2116739490 cites W2158606074 @default.
- W2116739490 cites W2168691817 @default.
- W2116739490 cites W2170493680 @default.
- W2116739490 cites W2259699005 @default.
- W2116739490 cites W2316184865 @default.
- W2116739490 cites W2322673970 @default.
- W2116739490 cites W3191020455 @default.
- W2116739490 cites W1990820605 @default.
- W2116739490 doi "https://doi.org/10.1093/qjmed/hcm121" @default.
- W2116739490 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18184668" @default.
- W2116739490 hasPublicationYear "2008" @default.
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