FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2116739536> ?p ?o ?g. }

• W2116739536 endingPage "999" @default.
• W2116739536 startingPage "981" @default.
• W2116739536 abstract "Dopaminergic neurons of the substantia nigra pars compacta (SNc) are involved in the control of movement, sleep, reward, learning, and nervous system disorders and disease. To date, a thorough characterization of the ion channel phenotype of this important neuronal population is lacking. Using immunohistochemistry, we analyzed the somatodendritic expression of voltage-gated ion channel subunits that are involved in pacemaking activity in SNc dopaminergic neurons in 6-, 21-, and 40-day-old rats. Our results demonstrate that the same complement of somatodendritic ion channels is present in SNc dopaminergic neurons from P6 to P40. The major developmental changes were an increase in the dendritic range of the immunolabeling for the HCN, T-type calcium, Kv4.3, delayed rectifier, and SK channels. Our study sheds light on the ion channel subunits that contribute to the somatodendritic delayed rectifier (Kv1.3, Kv2.1, Kv3.2, Kv3.3), A-type (Kv4.3) and calcium-activated SK (SK1, SK2, SK3) potassium currents, IH (mainly HCN2, HCN4), and the L- (Cav1.2, Cav1.3) and T-type (mainly Cav3.1, Cav3.3) calcium currents in SNc dopaminergic neurons. Finally, no robust differences in voltage-gated ion channel immunolabeling were observed across the population of SNc dopaminergic neurons for each age examined, suggesting that differing levels of individual ion channels are unlikely to distinguish between specific subpopulations of SNc dopaminergic neurons. This is significant in light of previous studies suggesting that age- or region-associated variations in the expression profile of voltage-gated ion channels in SNc dopaminergic neurons may underlie their vulnerability to dysfunction and disease. © 2014 Wiley Periodicals, Inc." @default.
• W2116739536 created "2016-06-24" @default.
• W2116739536 creator A5009276385 @default.
• W2116739536 creator A5057213917 @default.
• W2116739536 creator A5061379223 @default.
• W2116739536 date "2014-04-10" @default.
• W2116739536 modified "2023-10-03" @default.
• W2116739536 title "Somatodendritic ion channel expression in substantia nigra pars compacta dopaminergic neurons across postnatal development" @default.
• W2116739536 cites W1495154814 @default.
• W2116739536 cites W1510439895 @default.
• W2116739536 cites W1591573089 @default.
• W2116739536 cites W1823302046 @default.
• W2116739536 cites W1960266861 @default.
• W2116739536 cites W1962149957 @default.
• W2116739536 cites W1964023154 @default.
• W2116739536 cites W1965832750 @default.
• W2116739536 cites W1967368719 @default.
• W2116739536 cites W1974737922 @default.
• W2116739536 cites W1974898145 @default.
• W2116739536 cites W1976177818 @default.
• W2116739536 cites W1981271645 @default.
• W2116739536 cites W1982359426 @default.
• W2116739536 cites W1982524216 @default.
• W2116739536 cites W1984286247 @default.
• W2116739536 cites W1985541597 @default.
• W2116739536 cites W1987378376 @default.
• W2116739536 cites W1990514853 @default.
• W2116739536 cites W1990622058 @default.
• W2116739536 cites W1993585664 @default.
• W2116739536 cites W2002197406 @default.
• W2116739536 cites W2006200262 @default.
• W2116739536 cites W2009271710 @default.
• W2116739536 cites W2010651242 @default.
• W2116739536 cites W2011859711 @default.
• W2116739536 cites W2012561847 @default.
• W2116739536 cites W2014006573 @default.
• W2116739536 cites W2015816905 @default.
• W2116739536 cites W2019800529 @default.
• W2116739536 cites W2019879877 @default.
• W2116739536 cites W2020662075 @default.
• W2116739536 cites W2021272772 @default.
• W2116739536 cites W2021684176 @default.
• W2116739536 cites W2022062323 @default.
• W2116739536 cites W2023164168 @default.
• W2116739536 cites W2023695831 @default.
• W2116739536 cites W2023959801 @default.
• W2116739536 cites W2026010581 @default.
• W2116739536 cites W2026795314 @default.
• W2116739536 cites W2027899918 @default.
• W2116739536 cites W2030797610 @default.
• W2116739536 cites W2031222829 @default.
• W2116739536 cites W2032250203 @default.
• W2116739536 cites W2033712681 @default.
• W2116739536 cites W2033908484 @default.
• W2116739536 cites W2034218459 @default.
• W2116739536 cites W2035460326 @default.
• W2116739536 cites W2037137815 @default.
• W2116739536 cites W2037343279 @default.
• W2116739536 cites W2041174212 @default.
• W2116739536 cites W2042670053 @default.
• W2116739536 cites W2044975802 @default.
• W2116739536 cites W2048701474 @default.
• W2116739536 cites W2052480831 @default.
• W2116739536 cites W2053780113 @default.
• W2116739536 cites W2054498084 @default.
• W2116739536 cites W2057304417 @default.
• W2116739536 cites W2057688655 @default.
• W2116739536 cites W2057743912 @default.
• W2116739536 cites W2058423599 @default.
• W2116739536 cites W2058906901 @default.
• W2116739536 cites W2061766445 @default.
• W2116739536 cites W2064384972 @default.
• W2116739536 cites W2065914874 @default.
• W2116739536 cites W2067821044 @default.
• W2116739536 cites W2068093530 @default.
• W2116739536 cites W2076776707 @default.
• W2116739536 cites W2084142451 @default.
• W2116739536 cites W2085741616 @default.
• W2116739536 cites W2087219553 @default.
• W2116739536 cites W2089175380 @default.
• W2116739536 cites W2089705708 @default.
• W2116739536 cites W2092462980 @default.
• W2116739536 cites W2093852589 @default.
• W2116739536 cites W2097155839 @default.
• W2116739536 cites W2098934991 @default.
• W2116739536 cites W2100068597 @default.
• W2116739536 cites W2106149898 @default.
• W2116739536 cites W2107799893 @default.
• W2116739536 cites W2111348717 @default.
• W2116739536 cites W2113589752 @default.
• W2116739536 cites W2114561675 @default.
• W2116739536 cites W2120935292 @default.
• W2116739536 cites W2125323026 @default.
• W2116739536 cites W2135068360 @default.
• W2116739536 cites W2140817746 @default.
• W2116739536 cites W2148882983 @default.
• W2116739536 cites W2154370210 @default.
• W2116739536 cites W2159716898 @default.

• next