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• W2116739745 abstract "During their migration to the periphery, cranial neural crest cells (NCCs) are repulsed by an ErbB4-dependent cue(s) in the mesenchyme adjoining rhombomeres (r) 3 and 5, which are segmented hindbrain neuromeres. ErbB4 has many ligands, but which ligand functions in the above system has not yet been clearly determined. Here we found that a cornichon-like protein/cornichon homolog 2 (CNIL/CNIH2) gene was expressed in the developing chick r3 and r5. In a cell culture system, its product facilitated the secretion of heparin-binding epidermal growth factor-like growth factor (HB-EGF), one of the ligands of ErbB4. When CNIL function was perturbed in chick embryos by forced expression of a truncated form of CNIL, the distribution of NCCs was affected, which resulted in abnormal nerve fiber connections among the cranial sensory ganglia. Also, knockdown of CNIL or HB-EGF with siRNAs yielded a similar phenotype. This phenotype closely resembled that of ErbB4 knockout mouse embryos. Because HB-EGF was uniformly expressed in the embryonic hindbrain, CNIL seems to confine the site of HB-EGF action to r3 and r5 in concert with ErbB4." @default.
• W2116739745 created "2016-06-24" @default.
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• W2116739745 date "2007-04-01" @default.
• W2116739745 modified "2023-10-01" @default.
• W2116739745 title "Cornichon-like Protein Facilitates Secretion of HB-EGF and Regulates Proper Development of Cranial Nerves" @default.
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• W2116739745 doi "https://doi.org/10.1091/mbc.e06-08-0733" @default.
• W2116739745 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1839001" @default.
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• W2116739745 hasPublicationYear "2007" @default.
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