Matches in SemOpenAlex for { <https://semopenalex.org/work/W2116739864> ?p ?o ?g. }
- W2116739864 endingPage "2595" @default.
- W2116739864 startingPage "2587" @default.
- W2116739864 abstract "ABSTRACT The OspE2 product of Shigella spp., the expression of which is regulated by the mxiE gene, is secreted through a type III secretion system into host cells. We investigated the function of OspE2 of Shigella sonnei by using cultured epithelial cells. Cells invaded by an ospE2 deletion mutant altered their morphology into the rounding shape, which was not due to cell death, whereas cells invaded by the wild-type strain kept their cell shape intact. The ospE2 mutation did not affect initial cell entry and multiplication in cells, but the mutant formed smaller-than-normal plaques on cell monolayers, indicating a deficiency in cell-to-cell spread by the bacteria. An mxiE deletion mutant also showed changes in cell morphology and deficiency in bacterial spread to adjacent cells. In cells invaded by the ospE2 mutant, disturbance of actin stress fibers was prominent at 3 h after invasion. Analysis of OspE2 localization indicated that the OspE2 protein accumulated on focal contact-like structures in the infected host cells. These results suggest that colocalization of the OspE2 protein in the focal contacts of infected cells may function to maintain an intact cell morphology. The morphological change induced by invasion of the ospE2 mutant may affect secondary bacterial transmission." @default.
- W2116739864 created "2016-06-24" @default.
- W2116739864 creator A5010867165 @default.
- W2116739864 creator A5029156851 @default.
- W2116739864 creator A5029447023 @default.
- W2116739864 creator A5031287061 @default.
- W2116739864 creator A5065334263 @default.
- W2116739864 creator A5078541763 @default.
- W2116739864 date "2006-05-01" @default.
- W2116739864 modified "2023-09-30" @default.
- W2116739864 title "OspE2 of <i>Shigella sonnei</i> Is Required for the Maintenance of Cell Architecture of Bacterium-Infected Cells" @default.
- W2116739864 cites W1504748286 @default.
- W2116739864 cites W1539699466 @default.
- W2116739864 cites W1583038199 @default.
- W2116739864 cites W1586391720 @default.
- W2116739864 cites W1627263949 @default.
- W2116739864 cites W1808995665 @default.
- W2116739864 cites W1840817809 @default.
- W2116739864 cites W1844896946 @default.
- W2116739864 cites W1873199501 @default.
- W2116739864 cites W1876016322 @default.
- W2116739864 cites W1896768616 @default.
- W2116739864 cites W1949828943 @default.
- W2116739864 cites W1960007027 @default.
- W2116739864 cites W1971096395 @default.
- W2116739864 cites W1977644290 @default.
- W2116739864 cites W1978751572 @default.
- W2116739864 cites W1987706049 @default.
- W2116739864 cites W1988282769 @default.
- W2116739864 cites W1999453285 @default.
- W2116739864 cites W2008850485 @default.
- W2116739864 cites W2018910670 @default.
- W2116739864 cites W2021021541 @default.
- W2116739864 cites W2028622989 @default.
- W2116739864 cites W2034674930 @default.
- W2116739864 cites W2042607131 @default.
- W2116739864 cites W2046230501 @default.
- W2116739864 cites W2054936556 @default.
- W2116739864 cites W2077441699 @default.
- W2116739864 cites W2084708403 @default.
- W2116739864 cites W2086151987 @default.
- W2116739864 cites W2099836442 @default.
- W2116739864 cites W2100837269 @default.
- W2116739864 cites W2114674713 @default.
- W2116739864 cites W2115235932 @default.
- W2116739864 cites W2116137883 @default.
- W2116739864 cites W2117072224 @default.
- W2116739864 cites W2124081239 @default.
- W2116739864 cites W2124519714 @default.
- W2116739864 cites W2124537881 @default.
- W2116739864 cites W2131309206 @default.
- W2116739864 cites W2135880111 @default.
- W2116739864 cites W2142863488 @default.
- W2116739864 cites W2144713625 @default.
- W2116739864 cites W2144788546 @default.
- W2116739864 cites W2148853770 @default.
- W2116739864 cites W2149254554 @default.
- W2116739864 cites W2150322683 @default.
- W2116739864 cites W2154460798 @default.
- W2116739864 cites W2155196333 @default.
- W2116739864 cites W2160386606 @default.
- W2116739864 cites W2164633268 @default.
- W2116739864 cites W2170543527 @default.
- W2116739864 cites W2228492167 @default.
- W2116739864 cites W2337989323 @default.
- W2116739864 cites W39614084 @default.
- W2116739864 doi "https://doi.org/10.1128/iai.74.5.2587-2595.2006" @default.
- W2116739864 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1459745" @default.
- W2116739864 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16622194" @default.
- W2116739864 hasPublicationYear "2006" @default.
- W2116739864 type Work @default.
- W2116739864 sameAs 2116739864 @default.
- W2116739864 citedByCount "31" @default.
- W2116739864 countsByYear W21167398642012 @default.
- W2116739864 countsByYear W21167398642013 @default.
- W2116739864 countsByYear W21167398642014 @default.
- W2116739864 countsByYear W21167398642015 @default.
- W2116739864 countsByYear W21167398642016 @default.
- W2116739864 countsByYear W21167398642017 @default.
- W2116739864 countsByYear W21167398642019 @default.
- W2116739864 countsByYear W21167398642020 @default.
- W2116739864 countsByYear W21167398642021 @default.
- W2116739864 countsByYear W21167398642022 @default.
- W2116739864 countsByYear W21167398642023 @default.
- W2116739864 crossrefType "journal-article" @default.
- W2116739864 hasAuthorship W2116739864A5010867165 @default.
- W2116739864 hasAuthorship W2116739864A5029156851 @default.
- W2116739864 hasAuthorship W2116739864A5029447023 @default.
- W2116739864 hasAuthorship W2116739864A5031287061 @default.
- W2116739864 hasAuthorship W2116739864A5065334263 @default.
- W2116739864 hasAuthorship W2116739864A5078541763 @default.
- W2116739864 hasBestOaLocation W21167398641 @default.
- W2116739864 hasConcept C104317684 @default.
- W2116739864 hasConcept C143065580 @default.
- W2116739864 hasConcept C1491633281 @default.
- W2116739864 hasConcept C2776986154 @default.
- W2116739864 hasConcept C2781065037 @default.
- W2116739864 hasConcept C2911111840 @default.