FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2116740021> ?p ?o ?g. }

• W2116740021 endingPage "964" @default.
• W2116740021 startingPage "957" @default.
• W2116740021 abstract "Subtilisin propeptide functions as an intramolecular chaperone that guides precursor folding. Nattokinase, a member of subtilisin family, is synthesized as a precursor consisting of a signal peptide, a propeptide, and a subtilisin domain, and the mechanism of its folding remains to be understood. In this study, the essential residues of nattokinase propeptide which contribute to precursor folding were determined. Deletion analysis showed that the conserved regions in propeptide were important for precursor folding. Single-site and multi-site mutagenesis studies confirmed the role of Tyr10, Gly13, Gly34, and Gly35. During stage (i) and (ii) of precursor folding, Tyr10 and Gly13 would form the part of interface with subtilisin domain. While Gly34 and Gly35 connected with an α-helix that would stabilize the structure of propeptide. The quadruple Ala mutation, Y10A/G13A/G34A/G35A, resulted in a loss of the chaperone function for the propeptide. This work showed the essential residues of propeptide for precursor folding via secondary structure and kinetic parameter analyses." @default.
• W2116740021 created "2016-06-24" @default.
• W2116740021 creator A5019915753 @default.
• W2116740021 creator A5024309260 @default.
• W2116740021 creator A5030070743 @default.
• W2116740021 creator A5040150852 @default.
• W2116740021 creator A5049361267 @default.
• W2116740021 creator A5066218967 @default.
• W2116740021 creator A5071689816 @default.
• W2116740021 creator A5075744266 @default.
• W2116740021 date "2014-11-01" @default.
• W2116740021 modified "2023-10-18" @default.
• W2116740021 title "Four residues of propeptide are essential for precursor folding of nattokinase" @default.
• W2116740021 cites W1528474708 @default.
• W2116740021 cites W1669091873 @default.
• W2116740021 cites W1873199501 @default.
• W2116740021 cites W193968624 @default.
• W2116740021 cites W1973203775 @default.
• W2116740021 cites W1980435816 @default.
• W2116740021 cites W1983827715 @default.
• W2116740021 cites W1989085371 @default.
• W2116740021 cites W1990878089 @default.
• W2116740021 cites W1998330911 @default.
• W2116740021 cites W2026727532 @default.
• W2116740021 cites W2045777307 @default.
• W2116740021 cites W2049348076 @default.
• W2116740021 cites W2060913542 @default.
• W2116740021 cites W2062228103 @default.
• W2116740021 cites W2070603799 @default.
• W2116740021 cites W2074415411 @default.
• W2116740021 cites W2084911696 @default.
• W2116740021 cites W2087500898 @default.
• W2116740021 cites W2091414939 @default.
• W2116740021 cites W2091748192 @default.
• W2116740021 cites W2100837269 @default.
• W2116740021 cites W2102435105 @default.
• W2116740021 cites W2134929446 @default.
• W2116740021 cites W90850719 @default.
• W2116740021 doi "https://doi.org/10.1093/abbs/gmu093" @default.
• W2116740021 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25267722" @default.
• W2116740021 hasPublicationYear "2014" @default.
• W2116740021 type Work @default.
• W2116740021 sameAs 2116740021 @default.
• W2116740021 citedByCount "5" @default.
• W2116740021 countsByYear W21167400212016 @default.
• W2116740021 countsByYear W21167400212021 @default.
• W2116740021 countsByYear W21167400212022 @default.
• W2116740021 countsByYear W21167400212023 @default.
• W2116740021 crossrefType "journal-article" @default.
• W2116740021 hasAuthorship W2116740021A5019915753 @default.
• W2116740021 hasAuthorship W2116740021A5024309260 @default.
• W2116740021 hasAuthorship W2116740021A5030070743 @default.
• W2116740021 hasAuthorship W2116740021A5040150852 @default.
• W2116740021 hasAuthorship W2116740021A5049361267 @default.
• W2116740021 hasAuthorship W2116740021A5066218967 @default.
• W2116740021 hasAuthorship W2116740021A5071689816 @default.
• W2116740021 hasAuthorship W2116740021A5075744266 @default.
• W2116740021 hasConcept C100544194 @default.
• W2116740021 hasConcept C103408237 @default.
• W2116740021 hasConcept C104317684 @default.
• W2116740021 hasConcept C119599485 @default.
• W2116740021 hasConcept C127413603 @default.
• W2116740021 hasConcept C133571119 @default.
• W2116740021 hasConcept C142724271 @default.
• W2116740021 hasConcept C143065580 @default.
• W2116740021 hasConcept C181199279 @default.
• W2116740021 hasConcept C185592680 @default.
• W2116740021 hasConcept C204328495 @default.
• W2116740021 hasConcept C2775962898 @default.
• W2116740021 hasConcept C2776545253 @default.
• W2116740021 hasConcept C2778568395 @default.
• W2116740021 hasConcept C2779811187 @default.
• W2116740021 hasConcept C55493867 @default.
• W2116740021 hasConcept C62614982 @default.
• W2116740021 hasConcept C71924100 @default.
• W2116740021 hasConcept C7860815 @default.
• W2116740021 hasConceptScore W2116740021C100544194 @default.
• W2116740021 hasConceptScore W2116740021C103408237 @default.
• W2116740021 hasConceptScore W2116740021C104317684 @default.
• W2116740021 hasConceptScore W2116740021C119599485 @default.
• W2116740021 hasConceptScore W2116740021C127413603 @default.
• W2116740021 hasConceptScore W2116740021C133571119 @default.
• W2116740021 hasConceptScore W2116740021C142724271 @default.
• W2116740021 hasConceptScore W2116740021C143065580 @default.
• W2116740021 hasConceptScore W2116740021C181199279 @default.
• W2116740021 hasConceptScore W2116740021C185592680 @default.
• W2116740021 hasConceptScore W2116740021C204328495 @default.
• W2116740021 hasConceptScore W2116740021C2775962898 @default.
• W2116740021 hasConceptScore W2116740021C2776545253 @default.
• W2116740021 hasConceptScore W2116740021C2778568395 @default.
• W2116740021 hasConceptScore W2116740021C2779811187 @default.
• W2116740021 hasConceptScore W2116740021C55493867 @default.
• W2116740021 hasConceptScore W2116740021C62614982 @default.
• W2116740021 hasConceptScore W2116740021C71924100 @default.
• W2116740021 hasConceptScore W2116740021C7860815 @default.
• W2116740021 hasIssue "11" @default.
• W2116740021 hasLocation W21167400211 @default.
• W2116740021 hasLocation W21167400212 @default.

• next