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- W2116742393 abstract "To the Editor:We read with interest the recent editorial that called attention to antibodies to presynaptic molecules other than voltage-gated calcium channel (VGCC) in patients with seronegative Lambert-Eaton myasthenic syndrome (LEMS).1 In line with this proposal, we focused attention on vesicle membrane proteins that are implicated in the release of transmitter following presynaptic membrane depolarization and calcium entry. We chose synaptotagmin2 as a candidate for such a pathogenic protein, based on the fact that this protein acts as an exocytotic calcium receptor and is partly exposed at the surface of the nerve terminal during exocytosis. We synthesized a peptide corresponding to the extracellularly exposed N-terminus of synaptotagmin I. Repeated injection of Lewis rats with this protein plus adjuvant caused a LEMS feature as measured by microelectrode study; sera from the peptide-immunized rats possessed the antibody to synaptotagmin I, as demonstrated by an immunoblot using recombinant protein and monoclonal antibody.3The same immunoblot study as the animal experiment showed that sera from 12 of 47 patients with LEMS (26%) were positive for anti-synaptotagmin I; 4 of them (33%) were negative for anti-P/Q type-VGCC antibody and not associated …" @default.
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- W2116742393 date "2003-07-21" @default.
- W2116742393 modified "2023-09-26" @default.
- W2116742393 title "What's in the serum of seronegative MG and LEMS?" @default.
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- W2116742393 doi "https://doi.org/10.1212/wnl.61.2.277-a" @default.
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