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- W2116745507 abstract "Iatrogenic hypoglycemia is the limiting factor in the glycemic management of type 1 diabetes mellitus (T1DM) and advanced type 2 diabetes mellitus (T2DM) (1). Because of the interplay of relative or absolute therapeutic insulin excess— which must occur from time-to-time because of the pharmacokinetic imperfections of all insulin replacement regimens—and of compromised physiological and behavioral defenses against falling plasma glucose concentrations, the clinical syndromes of defective glucose counterregulation, and hypoglycemia unawareness, hypoglycemia is a barrier to true glycemic control in T1DM (2, 3) and insulin-requiring T2DM (4, 5). As a result, albeit at lower rates, long-term complications of diabetes occur despite aggressive attempts to reduce glycemia. For example, retinopathy developed or progressed in 14% of the patients with T1DM treated intensively (compared with 32% of those treated conventionally) in the Diabetes Control and Complications Trial (2), and a microvascular end point developed in 8% of the patients with T2DM treated intensively (compared with 11% of those treated conventionally) in the United Kingdom Prospective Diabetes Study (4). In the short term, hypoglycemia often" @default.
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- W2116745507 date "2000-06-01" @default.
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- W2116745507 title "Are Gender Differences in the Responses to Hypoglycemia Relevant to Iatrogenic Hypoglycemia in Type 1 Diabetes?" @default.
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- W2116745507 doi "https://doi.org/10.1210/jcem.85.6.6659" @default.
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