FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2116745900> ?p ?o ?g. }

• W2116745900 abstract "One of the main goals in cancer studies including high-throughput microRNA (miRNA) and mRNA data is to find and assess prognostic signatures capable of predicting clinical outcome. Both mRNA and miRNA expression changes in cancer diseases are described to reflect clinical characteristics like staging and prognosis. Furthermore, miRNA abundance can directly affect target transcripts and translation in tumor cells. Prediction models are trained to identify either mRNA or miRNA signatures for patient stratification. With the increasing number of microarray studies collecting mRNA and miRNA from the same patient cohort there is a need for statistical methods to integrate or fuse both kinds of data into one prediction model in order to find a combined signature that improves the prediction.Here, we propose a new method to fuse miRNA and mRNA data into one prediction model. Since miRNAs are known regulators of mRNAs we used the correlations between them as well as the target prediction information to build a bipartite graph representing the relations between miRNAs and mRNAs. This graph was used to guide the feature selection in order to improve the prediction. The method is illustrated on a prostate cancer data set comprising 98 patient samples with miRNA and mRNA expression data. The biochemical relapse was used as clinical endpoint. It could be shown that the bipartite graph in combination with both data sets could improve prediction performance as well as the stability of the feature selection.Fusion of mRNA and miRNA expression data into one prediction model improves clinical outcome prediction in terms of prediction error and stable feature selection. The R source code of the proposed method is available in the supplement." @default.
• W2116745900 created "2016-06-24" @default.
• W2116745900 creator A5003927940 @default.
• W2116745900 creator A5011534196 @default.
• W2116745900 creator A5017944645 @default.
• W2116745900 creator A5018616517 @default.
• W2116745900 creator A5023870399 @default.
• W2116745900 creator A5025249874 @default.
• W2116745900 creator A5046066862 @default.
• W2116745900 creator A5066647108 @default.
• W2116745900 creator A5080752508 @default.
• W2116745900 date "2011-12-01" @default.
• W2116745900 modified "2023-10-10" @default.
• W2116745900 title "Graph based fusion of miRNA and mRNA expression data improves clinical outcome prediction in prostate cancer" @default.
• W2116745900 cites W1546952499 @default.
• W2116745900 cites W1906461790 @default.
• W2116745900 cites W1986546598 @default.
• W2116745900 cites W1990072751 @default.
• W2116745900 cites W2000491596 @default.
• W2116745900 cites W2004005279 @default.
• W2116745900 cites W2006253576 @default.
• W2116745900 cites W2008945738 @default.
• W2116745900 cites W2013783925 @default.
• W2116745900 cites W2022667041 @default.
• W2116745900 cites W2024046085 @default.
• W2116745900 cites W2025266808 @default.
• W2116745900 cites W2026570544 @default.
• W2116745900 cites W2034280056 @default.
• W2116745900 cites W2036224487 @default.
• W2116745900 cites W2039656279 @default.
• W2116745900 cites W2040615655 @default.
• W2116745900 cites W2050869737 @default.
• W2116745900 cites W2052196460 @default.
• W2116745900 cites W2068241138 @default.
• W2116745900 cites W2073116379 @default.
• W2116745900 cites W2099234024 @default.
• W2116745900 cites W2099607215 @default.
• W2116745900 cites W2105632406 @default.
• W2116745900 cites W2105882193 @default.
• W2116745900 cites W2106787323 @default.
• W2116745900 cites W2107633226 @default.
• W2116745900 cites W2109972881 @default.
• W2116745900 cites W2116224763 @default.
• W2116745900 cites W2118352309 @default.
• W2116745900 cites W2120456037 @default.
• W2116745900 cites W2120865735 @default.
• W2116745900 cites W2128985829 @default.
• W2116745900 cites W2130979840 @default.
• W2116745900 cites W2136340483 @default.
• W2116745900 cites W2139792080 @default.
• W2116745900 cites W2149199519 @default.
• W2116745900 cites W2154947819 @default.
• W2116745900 cites W2911964244 @default.
• W2116745900 cites W3099478002 @default.
• W2116745900 cites W4245024447 @default.
• W2116745900 cites W4250236131 @default.
• W2116745900 cites W4293241248 @default.
• W2116745900 doi "https://doi.org/10.1186/1471-2105-12-488" @default.
• W2116745900 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3471479" @default.
• W2116745900 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22188670" @default.
• W2116745900 hasPublicationYear "2011" @default.
• W2116745900 type Work @default.
• W2116745900 sameAs 2116745900 @default.
• W2116745900 citedByCount "35" @default.
• W2116745900 countsByYear W21167459002012 @default.
• W2116745900 countsByYear W21167459002013 @default.
• W2116745900 countsByYear W21167459002014 @default.
• W2116745900 countsByYear W21167459002015 @default.
• W2116745900 countsByYear W21167459002016 @default.
• W2116745900 countsByYear W21167459002017 @default.
• W2116745900 countsByYear W21167459002018 @default.
• W2116745900 countsByYear W21167459002019 @default.
• W2116745900 countsByYear W21167459002020 @default.
• W2116745900 countsByYear W21167459002021 @default.
• W2116745900 countsByYear W21167459002023 @default.
• W2116745900 crossrefType "journal-article" @default.
• W2116745900 hasAuthorship W2116745900A5003927940 @default.
• W2116745900 hasAuthorship W2116745900A5011534196 @default.
• W2116745900 hasAuthorship W2116745900A5017944645 @default.
• W2116745900 hasAuthorship W2116745900A5018616517 @default.
• W2116745900 hasAuthorship W2116745900A5023870399 @default.
• W2116745900 hasAuthorship W2116745900A5025249874 @default.
• W2116745900 hasAuthorship W2116745900A5046066862 @default.
• W2116745900 hasAuthorship W2116745900A5066647108 @default.
• W2116745900 hasAuthorship W2116745900A5080752508 @default.
• W2116745900 hasBestOaLocation W21167459001 @default.
• W2116745900 hasConcept C104317684 @default.
• W2116745900 hasConcept C121608353 @default.
• W2116745900 hasConcept C124101348 @default.
• W2116745900 hasConcept C145059251 @default.
• W2116745900 hasConcept C148483581 @default.
• W2116745900 hasConcept C150194340 @default.
• W2116745900 hasConcept C154945302 @default.
• W2116745900 hasConcept C2780192828 @default.
• W2116745900 hasConcept C41008148 @default.
• W2116745900 hasConcept C54355233 @default.
• W2116745900 hasConcept C60644358 @default.
• W2116745900 hasConcept C70721500 @default.
• W2116745900 hasConcept C86803240 @default.
• W2116745900 hasConcept C95371953 @default.

• next