Matches in SemOpenAlex for { <https://semopenalex.org/work/W2116746025> ?p ?o ?g. }
- W2116746025 endingPage "520" @default.
- W2116746025 startingPage "513" @default.
- W2116746025 abstract "Background: Endocrine-disrupting chemicals (EDCs) may be involved in the etiology of autism spectrum disorders, but identifying relevant chemicals within mixtures of EDCs is difficult.Objective: Our goal was to identify gestational EDC exposures associated with autistic behaviors.Methods: We measured the concentrations of 8 phthalate metabolites, bisphenol A, 25 polychlorinated biphenyls (PCBs), 6 organochlorine pesticides, 8 brominated flame retardants, and 4 perfluoroalkyl substances in blood or urine samples from 175 pregnant women in the HOME (Health Outcomes and Measures of the Environment) Study (Cincinnati, OH). When children were 4 and 5 years old, mothers completed the Social Responsiveness Scale (SRS), a measure of autistic behaviors. We examined confounder-adjusted associations between 52 EDCs and SRS scores using a two-stage hierarchical analysis to account for repeated measures and confounding by correlated EDCs.Results: Most of the EDCs were associated with negligible absolute differences in SRS scores (≤ 1.5). Each 2-SD increase in serum concentrations of polybrominated diphenyl ether-28 (PBDE-28) (β = 2.5; 95% CI: –0.6, 5.6) or trans-nonachlor (β = 4.1; 95% CI: 0.8–7.3) was associated with more autistic behaviors. In contrast, fewer autistic behaviors were observed among children born to women with detectable versus nondetectable concentrations of PCB-178 (β = –3.0; 95% CI: –6.3, 0.2), β-hexachlorocyclohexane (β = –3.3; 95% CI: –6.1, –0.5), or PBDE-85 (β = –3.2; 95% CI: –5.9, –0.5). Increasing perfluorooctanoate (PFOA) concentrations were also associated with fewer autistic behaviors (β = –2.0; 95% CI: –4.4, 0.4).Conclusions: Some EDCs were associated with autistic behaviors in this cohort, but our modest sample size precludes us from dismissing chemicals with null associations. PFOA, β-hexachlorocyclohexane, PCB-178, PBDE-28, PBDE-85, and trans-nonachlor deserve additional scrutiny as factors that may be associated with childhood autistic behaviors.Citation: Braun JM, Kalkbrenner AE, Just AC, Yolton K, Calafat AM, Sjödin A, Hauser R, Webster GM, Chen A, Lanphear BP. 2014. Gestational exposure to endocrine-disrupting chemicals and reciprocal social, repetitive, and stereotypic behaviors in 4- and 5-year-old children: the HOME Study. Environ Health Perspect 122:513–520; http://dx.doi.org/10.1289/ehp.1307261" @default.
- W2116746025 created "2016-06-24" @default.
- W2116746025 creator A5013602281 @default.
- W2116746025 creator A5017911709 @default.
- W2116746025 creator A5021940732 @default.
- W2116746025 creator A5022871139 @default.
- W2116746025 creator A5034528790 @default.
- W2116746025 creator A5054265753 @default.
- W2116746025 creator A5055210116 @default.
- W2116746025 creator A5074562026 @default.
- W2116746025 creator A5079448339 @default.
- W2116746025 creator A5080164344 @default.
- W2116746025 date "2014-05-01" @default.
- W2116746025 modified "2023-10-17" @default.
- W2116746025 title "Gestational Exposure to Endocrine-Disrupting Chemicals and Reciprocal Social, Repetitive, and Stereotypic Behaviors in 4- and 5-Year-Old Children: The HOME Study" @default.
- W2116746025 cites W115538672 @default.
- W2116746025 cites W1965966912 @default.
- W2116746025 cites W1972427000 @default.
- W2116746025 cites W1976535068 @default.
- W2116746025 cites W1988514474 @default.
- W2116746025 cites W1991979585 @default.
- W2116746025 cites W1993108354 @default.
- W2116746025 cites W1993650845 @default.
- W2116746025 cites W1994103322 @default.
- W2116746025 cites W1995814341 @default.
- W2116746025 cites W2002138184 @default.
- W2116746025 cites W2003743209 @default.
- W2116746025 cites W2004722883 @default.
- W2116746025 cites W2009748009 @default.
- W2116746025 cites W2011232072 @default.
- W2116746025 cites W2016709601 @default.
- W2116746025 cites W2025956906 @default.
- W2116746025 cites W2034508698 @default.
- W2116746025 cites W2037056332 @default.
- W2116746025 cites W2037748044 @default.
- W2116746025 cites W2041473510 @default.
- W2116746025 cites W2042852386 @default.
- W2116746025 cites W2046496769 @default.
- W2116746025 cites W2053475025 @default.
- W2116746025 cites W2053820264 @default.
- W2116746025 cites W2063590320 @default.
- W2116746025 cites W2063744942 @default.
- W2116746025 cites W2067256255 @default.
- W2116746025 cites W2073874214 @default.
- W2116746025 cites W2074146148 @default.
- W2116746025 cites W2079531538 @default.
- W2116746025 cites W2082213808 @default.
- W2116746025 cites W2088363764 @default.
- W2116746025 cites W2094405673 @default.
- W2116746025 cites W2099737847 @default.
- W2116746025 cites W2109818577 @default.
- W2116746025 cites W2112997651 @default.
- W2116746025 cites W2113750680 @default.
- W2116746025 cites W2124958203 @default.
- W2116746025 cites W2130557242 @default.
- W2116746025 cites W2131009185 @default.
- W2116746025 cites W2132024398 @default.
- W2116746025 cites W2142495742 @default.
- W2116746025 cites W2145402394 @default.
- W2116746025 cites W2146533390 @default.
- W2116746025 cites W2148000302 @default.
- W2116746025 cites W2155103683 @default.
- W2116746025 cites W2163031031 @default.
- W2116746025 cites W2163849189 @default.
- W2116746025 cites W2166649563 @default.
- W2116746025 cites W2166972916 @default.
- W2116746025 cites W2914765137 @default.
- W2116746025 cites W4251941333 @default.
- W2116746025 cites W4296499091 @default.
- W2116746025 doi "https://doi.org/10.1289/ehp.1307261" @default.
- W2116746025 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4014765" @default.
- W2116746025 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24622245" @default.
- W2116746025 hasPublicationYear "2014" @default.
- W2116746025 type Work @default.
- W2116746025 sameAs 2116746025 @default.
- W2116746025 citedByCount "243" @default.
- W2116746025 countsByYear W21167460252014 @default.
- W2116746025 countsByYear W21167460252015 @default.
- W2116746025 countsByYear W21167460252016 @default.
- W2116746025 countsByYear W21167460252017 @default.
- W2116746025 countsByYear W21167460252018 @default.
- W2116746025 countsByYear W21167460252019 @default.
- W2116746025 countsByYear W21167460252020 @default.
- W2116746025 countsByYear W21167460252021 @default.
- W2116746025 countsByYear W21167460252022 @default.
- W2116746025 countsByYear W21167460252023 @default.
- W2116746025 crossrefType "journal-article" @default.
- W2116746025 hasAuthorship W2116746025A5013602281 @default.
- W2116746025 hasAuthorship W2116746025A5017911709 @default.
- W2116746025 hasAuthorship W2116746025A5021940732 @default.
- W2116746025 hasAuthorship W2116746025A5022871139 @default.
- W2116746025 hasAuthorship W2116746025A5034528790 @default.
- W2116746025 hasAuthorship W2116746025A5054265753 @default.
- W2116746025 hasAuthorship W2116746025A5055210116 @default.
- W2116746025 hasAuthorship W2116746025A5074562026 @default.
- W2116746025 hasAuthorship W2116746025A5079448339 @default.
- W2116746025 hasAuthorship W2116746025A5080164344 @default.
- W2116746025 hasBestOaLocation W21167460251 @default.