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- W2116747022 abstract "See article by Maitra et al. [12] (pages 715–725) in this issue. Integrins comprise a family of cell surface receptors known to attach cells to the extracellular matrix (ECM) and to mediate mechanical as well as chemical signals. Beyond ECM-mediated signalling to the cytosol (outside–in), extracellular binding activities are regulated through integrin-mediated signalling in the opposite direction (inside–out). Because integrins assemble large signalling complexes and activate multiple signalling pathways they are involved in an array of elementary biological functions such as control of cell cycle, proliferation as well as apoptosis [1].Integrins are heterodimers composed of non-covalently associated α- and β-subunits. In mammals at least eight β- and 16 α-subunits combining for 22 different receptors have been identified so far [2]. The β1-subunit composes the largest subfamily of integrins since it can associate with at least ten different α-subunits [3]. Integrins are widely expressed and dynamically regulated during development [4–6]. Their important role during early organotypic development has been unequivocally demonstrated in knock out models. For instance, deletion of the β1-integrin gene has resulted in early embryonic death during or shortly after implantation. Using a variety of elegant animal and cell models, deletion of the β1-integrin gene was further found to result in severe defects of migration and homing of cells of the hematopoietic system [7], alterations in neuronal development [8,9] and defective vasculo/angiogenesis [10]. Moreover, using β1-integrin deficient embryonic stem cells for the in vitro … * Corresponding author. Tel.: +49-221-478-6960; fax: +49-221-478-6965 j.hescheler{at}uni-koeln.de" @default.
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- W2116747022 title "Integrins and cell structure: powerful determinants of heart development and heart function" @default.
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