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• W2116747195 abstract "Alzheimer's Disease (AD), the most common form of dementia, is characterized by progressive loss of memory leading to gradual elimination of cognitive functions. Its neuropathological features include the extracellular amyloid plaques, that consist of amyloid β peptides (Aβ), and intracellular neurofibrillary tangles (NFTs) consisting of hyper-phosphorylated tau. Tau, a member of the Microtubule-Associated Proteins family, promotes the polymerization and stabilization of microtubules under physiological conditions. Pathological hyper-phosphorylation of tau, decreases its affinity for the microtubules, resulting in accumulation of the pathologic protein in the axons and disruption of the normal morphology and physiology of neurons. Among the factors involved in the development of sporadic AD (95% of total cases), is cerebral blood hypoperfusion and subsequent elimination of oxygen and glucose supply of the brain. Based on these data, we investigated the effects of glucose and oxygen deprivation on tau phosphorylation. Perfusion of acute brain slices from C57BL/6 mice with artificial cerebrospinal fluid supplemented with various oxygen and glucose concentrations. The levels of tau phosphorylation were evaluated by Western blot analysis of brain tissue protein extracts. Although hyper-phosphorylation of tau has been linked to AD, limited oxygen supply (2.5% O 2) reduced the phosphorylation of tau in all the examined residues. This effect was more potent when oxygen deprivation was combined with low levels of glucose (2mM) in the perfusion medium. GSK3 β kinase, one of the main regulators of the phosphorylation status of tau, did not seem to contribute to the observed changes. Interestingly, the hypoglycemia (2mM), alone, was not able to influence phospho-tau levels, while complete glucose withdrawal led to a significant decrease of tau phosphorylation. This effect, however, was more likely due to tau degradation, as indicated by the parallel elimination of its total protein levels. In support to our results, recent studies, suggest that, at the early stages of the disease, biosynthesis and energy metabolism are down-regulated, as a protective response to the reduced levels of nutrients and oxygen. Thus, our future research, in order to elucidate the implicated signaling pathways that lead to reduction of tau phosphorylation under these conditions, will focus on different tau-related kinases and phosphatases." @default.
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• W2116747195 date "2014-07-01" @default.
• W2116747195 modified "2023-09-27" @default.
• W2116747195 title "P1-320: STUDY OF THE EFFECT OF GLUCOSE AND OXYGEN DEPRIVATION ON THE PHOSPHORYLATION OF TAU" @default.
• W2116747195 doi "https://doi.org/10.1016/j.jalz.2014.05.561" @default.
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