Matches in SemOpenAlex for { <https://semopenalex.org/work/W2116747657> ?p ?o ?g. }
- W2116747657 endingPage "351" @default.
- W2116747657 startingPage "321" @default.
- W2116747657 abstract "Regulation of intracellular Ca2+ provides a means by which the strength and duration of cardiac muscle contraction is altered on a beat-to-beat basis. Ca2+ homeostasis is maintained by proteins of the outer cell membrane or sarcolemma and the sarcoplasmic reticulum, which is the major intracellular Ca2+ storage organelle. Recently, genetic engineering techniques designed to induce specific mutations, manipulate expression levels, or change a particular isoform of various membrane Ca(2+)-handling proteins have provided novel approaches in elucidating the physiological role of these gene products in the mammalian heart. This review summarizes findings in murine genetic models with alterations in the expression levels of the sarcolemmal Ca(2+)-ATPase and Na+/Ca2+ exchanger, which move Ca2+ across the cell membrane, and the sarcoplasmic reticulum proteins, which are involved in Ca2+ sequestration (Ca(2+)-ATPase and its regulator, phospholamban), Ca2+ storage (calsequestrin), and Ca2+ release (ryanodine receptor, FK506-binding protein and junctin) during excitation-contraction coupling. Advances in genetic technology, coupled with the development of miniaturized technology to assess cardiac function at multiple levels in the mouse, have added a wealth of new information to our understanding of the functional role of each of these membrane Ca(2+)-handling proteins in cardiac physiology and pathophysiology. Furthermore, these genetic models have provided valuable insights into the compensatory cross-talk mechanisms between the major membrane Ca(2+)-handling proteins in the mammalian heart." @default.
- W2116747657 created "2016-06-24" @default.
- W2116747657 creator A5024263113 @default.
- W2116747657 creator A5080329479 @default.
- W2116747657 date "2000-03-01" @default.
- W2116747657 modified "2023-09-27" @default.
- W2116747657 title "Genetically Engineered Models with Alterations in Cardiac Membrane Calcium-Handling Proteins" @default.
- W2116747657 cites W1509611865 @default.
- W2116747657 cites W1522775437 @default.
- W2116747657 cites W1530579275 @default.
- W2116747657 cites W1546876910 @default.
- W2116747657 cites W1549665441 @default.
- W2116747657 cites W1556428005 @default.
- W2116747657 cites W1567439646 @default.
- W2116747657 cites W1569195670 @default.
- W2116747657 cites W1593282904 @default.
- W2116747657 cites W1593848800 @default.
- W2116747657 cites W1605242131 @default.
- W2116747657 cites W1967688761 @default.
- W2116747657 cites W1968084774 @default.
- W2116747657 cites W1968709125 @default.
- W2116747657 cites W1972134881 @default.
- W2116747657 cites W1991141881 @default.
- W2116747657 cites W1991605997 @default.
- W2116747657 cites W1999184836 @default.
- W2116747657 cites W1999242870 @default.
- W2116747657 cites W1999832893 @default.
- W2116747657 cites W2001475413 @default.
- W2116747657 cites W2003946902 @default.
- W2116747657 cites W2004084338 @default.
- W2116747657 cites W2008089595 @default.
- W2116747657 cites W2014644229 @default.
- W2116747657 cites W2022109153 @default.
- W2116747657 cites W2024906448 @default.
- W2116747657 cites W2028421228 @default.
- W2116747657 cites W2034616654 @default.
- W2116747657 cites W2035885166 @default.
- W2116747657 cites W2039932112 @default.
- W2116747657 cites W2042646075 @default.
- W2116747657 cites W2045326768 @default.
- W2116747657 cites W2053104257 @default.
- W2116747657 cites W2053330560 @default.
- W2116747657 cites W2057994632 @default.
- W2116747657 cites W2059201211 @default.
- W2116747657 cites W2059769358 @default.
- W2116747657 cites W2061895140 @default.
- W2116747657 cites W2063994440 @default.
- W2116747657 cites W2064351258 @default.
- W2116747657 cites W2068250491 @default.
- W2116747657 cites W2069509176 @default.
- W2116747657 cites W2073306041 @default.
- W2116747657 cites W2080955459 @default.
- W2116747657 cites W2091867363 @default.
- W2116747657 cites W2092197701 @default.
- W2116747657 cites W2092528603 @default.
- W2116747657 cites W2097216911 @default.
- W2116747657 cites W2097761188 @default.
- W2116747657 cites W2106308397 @default.
- W2116747657 cites W2109123990 @default.
- W2116747657 cites W2111416247 @default.
- W2116747657 cites W2111867044 @default.
- W2116747657 cites W2112483818 @default.
- W2116747657 cites W2114851684 @default.
- W2116747657 cites W2120506542 @default.
- W2116747657 cites W2122403406 @default.
- W2116747657 cites W2135596278 @default.
- W2116747657 cites W2137069332 @default.
- W2116747657 cites W2138348928 @default.
- W2116747657 cites W2141385342 @default.
- W2116747657 cites W2142754357 @default.
- W2116747657 cites W2143930024 @default.
- W2116747657 cites W2154005496 @default.
- W2116747657 cites W2159111326 @default.
- W2116747657 cites W2160357702 @default.
- W2116747657 cites W2168903993 @default.
- W2116747657 cites W2188449804 @default.
- W2116747657 cites W2258593133 @default.
- W2116747657 cites W2415909923 @default.
- W2116747657 cites W2428721686 @default.
- W2116747657 cites W2462986294 @default.
- W2116747657 doi "https://doi.org/10.1146/annurev.physiol.62.1.321" @default.
- W2116747657 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10845094" @default.
- W2116747657 hasPublicationYear "2000" @default.
- W2116747657 type Work @default.
- W2116747657 sameAs 2116747657 @default.
- W2116747657 citedByCount "70" @default.
- W2116747657 countsByYear W21167476572012 @default.
- W2116747657 countsByYear W21167476572013 @default.
- W2116747657 countsByYear W21167476572014 @default.
- W2116747657 countsByYear W21167476572015 @default.
- W2116747657 countsByYear W21167476572016 @default.
- W2116747657 countsByYear W21167476572017 @default.
- W2116747657 countsByYear W21167476572018 @default.
- W2116747657 countsByYear W21167476572019 @default.
- W2116747657 countsByYear W21167476572023 @default.
- W2116747657 crossrefType "journal-article" @default.
- W2116747657 hasAuthorship W2116747657A5024263113 @default.
- W2116747657 hasAuthorship W2116747657A5080329479 @default.