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• W2116748520 abstract "To evaluate the pretreatment carcinoembryonic antigen (CEA) levels as a risk factor of para-aortic lymph node (PALN) recurrence in addition to squamous cell carcinoma antigen (SCC-Ag) levels following concurrent chemoradiotherapy (CCRT) for cervical cancer. From March 1995 to January 2008, 245 patients with squamous cell carcinoma of the uterine cervix were analyzed retrospectively. No patient received PALN irradiation as the initial treatment. PALN recurrence was detected by computer tomography (CT) scans. PALN relapse-free status was diagnosed clinically or radiographically. We analyzed the actuarial rates of PALN recurrence by using Kaplan-Meier curves. Multivariate analyses were carried out with Cox regression models. The median time of follow-up was 45.5 months (range 1-160). CEA ≥ 10 ng/mL (p < 0.001) was a risk factor of PALN recurrence in addition to SCC-Ag levels ≥ 40 ng/mL (p < 0.001), SCC-Ag levels of 20-40 ng/mL (p = 0.022), SCC-Ag levels of 10-20 ng/mL (p = 0.004) on a multivariate analysis. The 5-year PALN recurrence rates in patients with CEA ≥ 10 ng/mL, SCC-Ag levels ≥ 40 ng/mL, SCC-Ag levels of 20-40 ng/mL, SCC-Ag levels of 10-20 ng/mL, and both low levels of tumor markers were 39%, 55.5%, 21.9%, 27.2%, and 8%, respectively. The median time of PALN recurrence in patients with CEA levels ≥ 10 ng/mL was 6.9 months (range 0-21.5). The corresponding time was 16.3 months (range 3.2-94.3) in patients with both SCC-Ag levels ≥ 10 ng/mL and CEA levels < 10 ng/mL. The 5-year PALN recurrence rates in patients with high-risk (SCC-Ag levels ≥ 40 ng/mL), intermediate-risk (either SCC-Ag levels of 10-40 ng/mL or CEA levels ≥ 10 ng/mL), and low-risk (both SCC-Ag levels < 10 ng/mL and CEA levels <10 ng/mL) were 55.5%, 29.5%, and 8%, respectively. CEA is an additional risk factor of PALN relapse in patients with squamous cell carcinoma of the uterine cervix following definitive CCRT. The onset of PALN relapse is early in patients with high CEA levels. More comprehensive examinations before CCRT and intensive follow-up schedules are suggested for early detection and salvage in patients with SCC-Ag or CEA levels ≥ 10 ng/mL. Further study of prophylactic PALN irradiation may be considered for such patients." @default.
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• W2116748520 date "2010-11-01" @default.
• W2116748520 modified "2023-09-25" @default.
• W2116748520 title "Pretreatment Carcinoembryonic Antigen Level is a Risk Factor of Para-aortic Lymph Node Recurrence in Addition to Squamous Cell Carcinoma Antigen after Definitive Concurrent Chemoradiotherapy For Squamous Cell Carcinoma Of The Uterine Cervix" @default.
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• W2116748520 doi "https://doi.org/10.1016/j.ijrobp.2010.07.934" @default.
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