FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2116748676> ?p ?o ?g. }

• W2116748676 endingPage "565" @default.
• W2116748676 startingPage "557" @default.
• W2116748676 abstract "Abstract Mesenchymal stem cells (MSCs) are very attractive candidates in cell-based strategies that target inflammatory diseases. Preclinical animal studies and many clinical trials have demonstrated that human MSCs can be safely administered and that they modify the inflammatory process in the targeted injured tissue. Our laboratory developed a novel method that optimizes the anti-inflammatory effects of MSCs. We termed the cells prepared by this method MSC2. In this study, we determined the effects of MSC2-based therapies on an inflammation-linked painful diabetic peripheral neuropathy (pDPN) mouse model. Streptozotocin-induced diabetic mice were treated with conventionally prepared MSCs, MSC2, or vehicle at three specific time points. Prior to each treatment, responses to radiant heat (Hargreaves) and mechanical stimuli (von Frey) were measured. Blood serum from each animal was collected at the end of the study to compare levels of inflammatory markers between the treatment groups. We observed that MSC2-treated mice had significant improvement in behavioral assays compared with the vehicle and MSC groups, and moreover these responses did not differ from the observations seen in the healthy wild-type control group. Mice treated with conventional MSCs showed significant improvement in the radiant heat assay, but not in the von Frey test. Additionally, mice treated with MSC2 had decreased serum levels in many proinflammatory cytokines compared with the values measured in the MSC- or vehicle-treated groups. These findings indicate that MSC2-based therapy is a new anti-inflammatory treatment to consider in the management of pDPN." @default.
• W2116748676 created "2016-06-24" @default.
• W2116748676 creator A5030770841 @default.
• W2116748676 creator A5043846432 @default.
• W2116748676 creator A5056071800 @default.
• W2116748676 creator A5060129235 @default.
• W2116748676 creator A5075402768 @default.
• W2116748676 creator A5079566352 @default.
• W2116748676 date "2012-07-01" @default.
• W2116748676 modified "2023-10-17" @default.
• W2116748676 title "Anti-Inflammatory Mesenchymal Stem Cells (<i>MSC2</i>) Attenuate Symptoms of Painful Diabetic Peripheral Neuropathy" @default.
• W2116748676 cites W1576673253 @default.
• W2116748676 cites W1969832663 @default.
• W2116748676 cites W1978370369 @default.
• W2116748676 cites W1983419371 @default.
• W2116748676 cites W1989500669 @default.
• W2116748676 cites W1998309390 @default.
• W2116748676 cites W1999344705 @default.
• W2116748676 cites W2004646124 @default.
• W2116748676 cites W2010942808 @default.
• W2116748676 cites W2012662529 @default.
• W2116748676 cites W2013195172 @default.
• W2116748676 cites W2014007136 @default.
• W2116748676 cites W2016748877 @default.
• W2116748676 cites W2018224697 @default.
• W2116748676 cites W2018763967 @default.
• W2116748676 cites W2020006845 @default.
• W2116748676 cites W2021043915 @default.
• W2116748676 cites W2030912622 @default.
• W2116748676 cites W2031518671 @default.
• W2116748676 cites W2046854715 @default.
• W2116748676 cites W2061803566 @default.
• W2116748676 cites W2063307212 @default.
• W2116748676 cites W2067845216 @default.
• W2116748676 cites W2069396466 @default.
• W2116748676 cites W2073024911 @default.
• W2116748676 cites W2075553837 @default.
• W2116748676 cites W2080722204 @default.
• W2116748676 cites W2081200173 @default.
• W2116748676 cites W2087042369 @default.
• W2116748676 cites W2090886213 @default.
• W2116748676 cites W2091273694 @default.
• W2116748676 cites W2099905857 @default.
• W2116748676 cites W2102347733 @default.
• W2116748676 cites W2102857575 @default.
• W2116748676 cites W2105305534 @default.
• W2116748676 cites W2109748103 @default.
• W2116748676 cites W2114066412 @default.
• W2116748676 cites W2114609602 @default.
• W2116748676 cites W2118934189 @default.
• W2116748676 cites W2125316317 @default.
• W2116748676 cites W2128202887 @default.
• W2116748676 cites W2138607907 @default.
• W2116748676 cites W2139079059 @default.
• W2116748676 cites W2141049046 @default.
• W2116748676 cites W2145692448 @default.
• W2116748676 cites W2149813500 @default.
• W2116748676 cites W2150661797 @default.
• W2116748676 cites W2153112493 @default.
• W2116748676 cites W2153789216 @default.
• W2116748676 cites W2154536095 @default.
• W2116748676 cites W2158179799 @default.
• W2116748676 cites W2165301449 @default.
• W2116748676 cites W2165494344 @default.
• W2116748676 cites W2172201406 @default.
• W2116748676 cites W2329242769 @default.
• W2116748676 cites W2410330794 @default.
• W2116748676 cites W4254126159 @default.
• W2116748676 doi "https://doi.org/10.5966/sctm.2012-0025" @default.
• W2116748676 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3659725" @default.
• W2116748676 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23197860" @default.
• W2116748676 hasPublicationYear "2012" @default.
• W2116748676 type Work @default.
• W2116748676 sameAs 2116748676 @default.
• W2116748676 citedByCount "64" @default.
• W2116748676 countsByYear W21167486762012 @default.
• W2116748676 countsByYear W21167486762013 @default.
• W2116748676 countsByYear W21167486762014 @default.
• W2116748676 countsByYear W21167486762015 @default.
• W2116748676 countsByYear W21167486762016 @default.
• W2116748676 countsByYear W21167486762017 @default.
• W2116748676 countsByYear W21167486762018 @default.
• W2116748676 countsByYear W21167486762019 @default.
• W2116748676 countsByYear W21167486762020 @default.
• W2116748676 countsByYear W21167486762021 @default.
• W2116748676 countsByYear W21167486762022 @default.
• W2116748676 crossrefType "journal-article" @default.
• W2116748676 hasAuthorship W2116748676A5030770841 @default.
• W2116748676 hasAuthorship W2116748676A5043846432 @default.
• W2116748676 hasAuthorship W2116748676A5056071800 @default.
• W2116748676 hasAuthorship W2116748676A5060129235 @default.
• W2116748676 hasAuthorship W2116748676A5075402768 @default.
• W2116748676 hasAuthorship W2116748676A5079566352 @default.
• W2116748676 hasBestOaLocation W21167486761 @default.
• W2116748676 hasConcept C126322002 @default.
• W2116748676 hasConcept C134018914 @default.
• W2116748676 hasConcept C142724271 @default.
• W2116748676 hasConcept C164027704 @default.

• next