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- W2116761075 abstract "The distal femur is the most common site of acute long bone diaphyseal infarcts in children with sickle cell anaemia. Four cases of growth disturbance following such infarcts and/or superimposed osteomyelitis are presented. The deformities may be similar to the triangular epiphyses and cupped metaphyses which occur elsewhere, especially in the hands and feet. They may appear as linear radiolucent ‘channels’ extending from the metaphyses into the shafts. The two can occur together.Vascular and other factors responsible for their development are described. A variety of such defects may occur. This is thought to be due to the many different mechanisms which can be involved in their production: epiphyseal and/or metaphyseal vascular ischaemia, osteoporosis, revascularization and bone resorption after infarction, structural responses to weight bearing stresses and periods of growth arrest. Patients with sickle cell anaemia who develop bone infarcts in the metaphyseal region of the distal femur are predisposed to these factors. They also commonly develop osteomyelitis at the site of bone infarction, and this alone is known to produce similar growth disturbances." @default.
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- W2116761075 date "1970-10-01" @default.
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- W2116761075 title "Foot manifestations of the congenital malformation syndromes" @default.
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- W2116761075 doi "https://doi.org/10.1016/s0037-198x(70)80005-0" @default.
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