FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2116765336> ?p ?o ?g. }

• W2116765336 endingPage "1684" @default.
• W2116765336 startingPage "1675" @default.
• W2116765336 abstract "Abstract We previously showed that treatment of prostate cancer cells with soy isoflavones and radiation resulted in greater cell killing in vitro, and caused downregulation of NF‐κB and APE1/Ref‐1. APE1/Ref‐1 functions as a redox activator of transcription factors, including NF‐κB and HIF‐1α. These molecules are upregulated by radiation and implicated in radioresistance of cancer cells. We extended our studies to investigate the role of HIF‐1α survival pathway and its upstream Src and STAT3 molecules in isoflavones and radiation interaction. Radiation induced phosphorylation of Src and STAT3 leading to induction of HIF‐1α. Genistein, daidzein or a mixture of soy isoflavones did not activate this pathway. These data were observed both in PC‐3 (AR‐) and C4‐2B (AR+) androgen‐independent cell lines. Pretreatment with isoflavones inhibited Src/STAT3/HIF‐1α activation by radiation and nuclear translocation of HIF‐1α. These findings correlated with decreased expression of APE1/Ref‐1 and DNA binding activity of HIF‐1α and NF‐κB. In APE1/Ref‐1 cDNA transfected cells, radiation caused a greater increase in HIF‐1α and NF‐κB activities but this effect was inhibited by pretreatment with soy prior to radiation. Transfection experiments indicate that APE1/Ref‐1 inhibition by isoflavones impairs the radiation‐induced transcription activity of NF‐κB and HIF‐1α. This mechanism could result in the inhibition of genes essential for tumor growth and angiogenesis, as demonstrated by inhibition of VEGF production and HUVECs tube formation. Our novel findings suggest that the increased responsiveness to radiation mediated by soy isoflavones could be due to pleiotropic effects of isoflavones blocking cell survival pathways induced by radiation including Src/STAT3/HIF‐1α, APE1/Ref‐1 and NF‐κB. © 2008 Wiley‐Liss, Inc." @default.
• W2116765336 created "2016-06-24" @default.
• W2116765336 creator A5042547707 @default.
• W2116765336 creator A5049341927 @default.
• W2116765336 creator A5054504867 @default.
• W2116765336 creator A5055092589 @default.
• W2116765336 creator A5070316994 @default.
• W2116765336 creator A5070588827 @default.
• W2116765336 creator A5080528828 @default.
• W2116765336 date "2009-01-27" @default.
• W2116765336 modified "2023-10-18" @default.
• W2116765336 title "Radiation-induced HIF-1α cell survival pathway is inhibited by soy isoflavones in prostate cancer cells" @default.
• W2116765336 cites W122518273 @default.
• W2116765336 cites W1498787975 @default.
• W2116765336 cites W1548640328 @default.
• W2116765336 cites W1937401270 @default.
• W2116765336 cites W1963644478 @default.
• W2116765336 cites W1964037605 @default.
• W2116765336 cites W1965734230 @default.
• W2116765336 cites W1977077904 @default.
• W2116765336 cites W1982317652 @default.
• W2116765336 cites W1986158803 @default.
• W2116765336 cites W1987559776 @default.
• W2116765336 cites W1990670707 @default.
• W2116765336 cites W1994508517 @default.
• W2116765336 cites W1998709679 @default.
• W2116765336 cites W2004442904 @default.
• W2116765336 cites W2013818100 @default.
• W2116765336 cites W2016001610 @default.
• W2116765336 cites W2026114871 @default.
• W2116765336 cites W2030575063 @default.
• W2116765336 cites W2036988959 @default.
• W2116765336 cites W2039271361 @default.
• W2116765336 cites W2053298425 @default.
• W2116765336 cites W2055054323 @default.
• W2116765336 cites W2056699603 @default.
• W2116765336 cites W2062098696 @default.
• W2116765336 cites W2063477993 @default.
• W2116765336 cites W2072839085 @default.
• W2116765336 cites W2079588482 @default.
• W2116765336 cites W2111631361 @default.
• W2116765336 cites W2120350306 @default.
• W2116765336 cites W2126372787 @default.
• W2116765336 cites W2140418048 @default.
• W2116765336 cites W2141528928 @default.
• W2116765336 cites W2142716359 @default.
• W2116765336 cites W2144662794 @default.
• W2116765336 cites W2145474225 @default.
• W2116765336 cites W2147301416 @default.
• W2116765336 cites W2148156146 @default.
• W2116765336 cites W2153734946 @default.
• W2116765336 cites W2157820793 @default.
• W2116765336 cites W2159955722 @default.
• W2116765336 cites W2161229780 @default.
• W2116765336 cites W2167570951 @default.
• W2116765336 cites W2273998766 @default.
• W2116765336 cites W2410480226 @default.
• W2116765336 doi "https://doi.org/10.1002/ijc.24015" @default.
• W2116765336 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2670478" @default.
• W2116765336 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19101986" @default.
• W2116765336 hasPublicationYear "2009" @default.
• W2116765336 type Work @default.
• W2116765336 sameAs 2116765336 @default.
• W2116765336 citedByCount "89" @default.
• W2116765336 countsByYear W21167653362012 @default.
• W2116765336 countsByYear W21167653362013 @default.
• W2116765336 countsByYear W21167653362014 @default.
• W2116765336 countsByYear W21167653362015 @default.
• W2116765336 countsByYear W21167653362016 @default.
• W2116765336 countsByYear W21167653362017 @default.
• W2116765336 countsByYear W21167653362018 @default.
• W2116765336 countsByYear W21167653362019 @default.
• W2116765336 countsByYear W21167653362020 @default.
• W2116765336 countsByYear W21167653362021 @default.
• W2116765336 countsByYear W21167653362022 @default.
• W2116765336 countsByYear W21167653362023 @default.
• W2116765336 crossrefType "journal-article" @default.
• W2116765336 hasAuthorship W2116765336A5042547707 @default.
• W2116765336 hasAuthorship W2116765336A5049341927 @default.
• W2116765336 hasAuthorship W2116765336A5054504867 @default.
• W2116765336 hasAuthorship W2116765336A5055092589 @default.
• W2116765336 hasAuthorship W2116765336A5070316994 @default.
• W2116765336 hasAuthorship W2116765336A5070588827 @default.
• W2116765336 hasAuthorship W2116765336A5080528828 @default.
• W2116765336 hasBestOaLocation W21167653361 @default.
• W2116765336 hasConcept C104317684 @default.
• W2116765336 hasConcept C127561419 @default.
• W2116765336 hasConcept C134018914 @default.
• W2116765336 hasConcept C153911025 @default.
• W2116765336 hasConcept C185592680 @default.
• W2116765336 hasConcept C2778298627 @default.
• W2116765336 hasConcept C2778923194 @default.
• W2116765336 hasConcept C2779705811 @default.
• W2116765336 hasConcept C2780394083 @default.
• W2116765336 hasConcept C502942594 @default.
• W2116765336 hasConcept C54355233 @default.
• W2116765336 hasConcept C55493867 @default.
• W2116765336 hasConcept C58962609 @default.

• next