FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2116766667> ?p ?o ?g. }

• W2116766667 endingPage "1488" @default.
• W2116766667 startingPage "1482" @default.
• W2116766667 abstract "The objective of this prospective, randomized, open-label, blinded-endpoint study was to compare the antihypertensive efficacy of valsartan 80 mg v irbesartan 150 mg when combined with hydrochlorothiazide (HCTZ) 12.5 mg. Untreated or uncontrolled hypertensive adults (n = 800) were enrolled by primary care physicians. After a 5-week open-label lead-in phase in which all patients received 12.5 mg HCTZ once daily, subjects whose blood pressure (BP) remained uncontrolled were randomized (n = 464) to valsartan/HCTZ (80/12.5 mg) or irbesartan/HCTZ (150/12.5 mg) for 8 weeks. Home BP monitoring (HBPM) was performed in the morning and in the evening for 5 days, at baseline, and after 8 weeks. Office BP measurements were obtained at baseline and after 8 weeks. Irbesartan/HCTZ produced greater reductions in average systolic BP (SBP) and diastolic BP (DBP) measured by HBPM than valsartan/HCTZ (SBP: −13.0 v −10.6 mm Hg, P = .0094; DBP: −9.5 v −7.4 mm Hg, P = .0007). These differences were more pronounced in the morning (trough) than in the evening. Office BP measurements also showed greater reductions in trough seated SBP and DBP with irbesartan/HCTZ compared with valsartan/HCTZ. Normalization rates observed with HBPM (SBP <135 mm Hg and DBP <85 mm Hg) were significantly greater with irbesartan/HCTZ than with valsartan/HCTZ (50.2 v 33.2%; P = .0003). The overall safety was similar in the two groups. The superior BP-lowering potency of the fixed combination irbesartan/HCTZ (150/12.5 mg) over valsartan/HCTZ (80/12.5 mg), evidenced independently from the investigators by HBPM, supports the use of this technique in trials with prospective, randomized, open-label, blinded-endpoint designs. Am J Hypertens 2005;18:1482–1488 © 2005 American Journal of Hypertension, Ltd." @default.
• W2116766667 created "2016-06-24" @default.
• W2116766667 creator A5042310222 @default.
• W2116766667 creator A5065626802 @default.
• W2116766667 creator A5066262141 @default.
• W2116766667 creator A5086008732 @default.
• W2116766667 creator A5088372894 @default.
• W2116766667 creator A5091688928 @default.
• W2116766667 date "2005-11-01" @default.
• W2116766667 modified "2023-10-12" @default.
• W2116766667 title "A Home Blood Pressure Monitoring Study Comparing the Antihypertensive Efficacy of Two Angiotensin II Receptor Antagonist Fixed Combinations" @default.
• W2116766667 cites W1497461844 @default.
• W2116766667 cites W1710832400 @default.
• W2116766667 cites W1965573335 @default.
• W2116766667 cites W1972278133 @default.
• W2116766667 cites W1974665026 @default.
• W2116766667 cites W1981090269 @default.
• W2116766667 cites W1984571776 @default.
• W2116766667 cites W1989118729 @default.
• W2116766667 cites W2002100658 @default.
• W2116766667 cites W2045202208 @default.
• W2116766667 cites W2053967476 @default.
• W2116766667 cites W2066205209 @default.
• W2116766667 cites W2076778401 @default.
• W2116766667 cites W2084550660 @default.
• W2116766667 cites W2102979143 @default.
• W2116766667 cites W2130229820 @default.
• W2116766667 cites W2131494018 @default.
• W2116766667 cites W2137408480 @default.
• W2116766667 cites W2141659719 @default.
• W2116766667 cites W2142738495 @default.
• W2116766667 cites W2146851676 @default.
• W2116766667 cites W2156121263 @default.
• W2116766667 cites W2165141146 @default.
• W2116766667 cites W2172032309 @default.
• W2116766667 cites W2189592079 @default.
• W2116766667 cites W2332518901 @default.
• W2116766667 cites W2405921309 @default.
• W2116766667 cites W2923575032 @default.
• W2116766667 cites W75245760 @default.
• W2116766667 doi "https://doi.org/10.1016/j.amjhyper.2005.06.009" @default.
• W2116766667 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16280286" @default.
• W2116766667 hasPublicationYear "2005" @default.
• W2116766667 type Work @default.
• W2116766667 sameAs 2116766667 @default.
• W2116766667 citedByCount "43" @default.
• W2116766667 countsByYear W21167666672012 @default.
• W2116766667 countsByYear W21167666672013 @default.
• W2116766667 countsByYear W21167666672014 @default.
• W2116766667 countsByYear W21167666672015 @default.
• W2116766667 countsByYear W21167666672021 @default.
• W2116766667 crossrefType "journal-article" @default.
• W2116766667 hasAuthorship W2116766667A5042310222 @default.
• W2116766667 hasAuthorship W2116766667A5065626802 @default.
• W2116766667 hasAuthorship W2116766667A5066262141 @default.
• W2116766667 hasAuthorship W2116766667A5086008732 @default.
• W2116766667 hasAuthorship W2116766667A5088372894 @default.
• W2116766667 hasAuthorship W2116766667A5091688928 @default.
• W2116766667 hasBestOaLocation W21167666671 @default.
• W2116766667 hasConcept C121332964 @default.
• W2116766667 hasConcept C126322002 @default.
• W2116766667 hasConcept C126894567 @default.
• W2116766667 hasConcept C1276947 @default.
• W2116766667 hasConcept C134018914 @default.
• W2116766667 hasConcept C19720800 @default.
• W2116766667 hasConcept C2776476923 @default.
• W2116766667 hasConcept C2777387769 @default.
• W2116766667 hasConcept C2780259554 @default.
• W2116766667 hasConcept C2780361556 @default.
• W2116766667 hasConcept C2908929049 @default.
• W2116766667 hasConcept C71924100 @default.
• W2116766667 hasConcept C84393581 @default.
• W2116766667 hasConcept C98274493 @default.
• W2116766667 hasConceptScore W2116766667C121332964 @default.
• W2116766667 hasConceptScore W2116766667C126322002 @default.
• W2116766667 hasConceptScore W2116766667C126894567 @default.
• W2116766667 hasConceptScore W2116766667C1276947 @default.
• W2116766667 hasConceptScore W2116766667C134018914 @default.
• W2116766667 hasConceptScore W2116766667C19720800 @default.
• W2116766667 hasConceptScore W2116766667C2776476923 @default.
• W2116766667 hasConceptScore W2116766667C2777387769 @default.
• W2116766667 hasConceptScore W2116766667C2780259554 @default.
• W2116766667 hasConceptScore W2116766667C2780361556 @default.
• W2116766667 hasConceptScore W2116766667C2908929049 @default.
• W2116766667 hasConceptScore W2116766667C71924100 @default.
• W2116766667 hasConceptScore W2116766667C84393581 @default.
• W2116766667 hasConceptScore W2116766667C98274493 @default.
• W2116766667 hasIssue "11" @default.
• W2116766667 hasLocation W21167666671 @default.
• W2116766667 hasLocation W21167666672 @default.
• W2116766667 hasOpenAccess W2116766667 @default.
• W2116766667 hasPrimaryLocation W21167666671 @default.
• W2116766667 hasRelatedWork W2293828765 @default.
• W2116766667 hasRelatedWork W2359117419 @default.
• W2116766667 hasRelatedWork W2364708382 @default.
• W2116766667 hasRelatedWork W2367637970 @default.
• W2116766667 hasRelatedWork W2375183267 @default.
• W2116766667 hasRelatedWork W2375278169 @default.

• next