Matches in SemOpenAlex for { <https://semopenalex.org/work/W2116767120> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2116767120 startingPage "3896" @default.
- W2116767120 abstract "The Ca 2+ -activated potassium channel, K Ca 3.1, is implicated in the process of exocytic release of intracellular granules from secretory cells such as human lung mast cells (HLMCs). MUC5AC is a human mucin that is upregulated in asthmatic human airways, and is hypothesised to be released from secretory human bronchial epithelial cells (HBECs) via exocytosis of intracellular granules. The aim was to investigate whether K Ca 3.1 plays a role in MUC5AC synthesis and secretion from HBECs. Expression of MUC5AC and K Ca 3.1 was investigated in primary HBEC cultures using quantitative RT-PCR and western blotting, and in bronchial biopsies using immunohistochemistry. K Ca 3.1 activity was examined using patch clamp electrophysiology. K Ca 3.1 mRNA expression was similar in submerged asthmatic and healthy HBECs, and protein expression was evident in western blots. MUC5AC and K Ca 3.1 immunoreactivity were demonstrated in the bronchial epithelium in severe, moderate and mild asthmatics, and in healthy controls. MUC5AC and K Ca 3.1 immunostaining co-localised in approximately 50% of cells. Severe asthmatic bronchial epithelium displayed higher levels of K Ca 3.1 (P = 0.001) and MUC5AC (P = 0.018) immunostaining. Asthmatic HBECs exhibited larger K Ca 3.1 currents than healthy HBECs (P = 0.023). Co-localisation of MUC5AC with K Ca 3.1 immunostaining suggests that mucus-secreting airway epithelial cells express K Ca 3.1. These results demonstrate the potential for K Ca 3.1 to contribute to pathological mucus secretion in asthma." @default.
- W2116767120 created "2016-06-24" @default.
- W2116767120 creator A5022294504 @default.
- W2116767120 creator A5043495928 @default.
- W2116767120 creator A5074952330 @default.
- W2116767120 date "2014-09-01" @default.
- W2116767120 modified "2023-09-28" @default.
- W2116767120 title "The role of the KCa3.1 channel in the regulation of airway mucus hypersecretion in asthma" @default.
- W2116767120 hasPublicationYear "2014" @default.
- W2116767120 type Work @default.
- W2116767120 sameAs 2116767120 @default.
- W2116767120 citedByCount "0" @default.
- W2116767120 crossrefType "journal-article" @default.
- W2116767120 hasAuthorship W2116767120A5022294504 @default.
- W2116767120 hasAuthorship W2116767120A5043495928 @default.
- W2116767120 hasAuthorship W2116767120A5074952330 @default.
- W2116767120 hasConcept C104317684 @default.
- W2116767120 hasConcept C126322002 @default.
- W2116767120 hasConcept C142724271 @default.
- W2116767120 hasConcept C179264091 @default.
- W2116767120 hasConcept C18903297 @default.
- W2116767120 hasConcept C203014093 @default.
- W2116767120 hasConcept C204232928 @default.
- W2116767120 hasConcept C2777312293 @default.
- W2116767120 hasConcept C4224716 @default.
- W2116767120 hasConcept C49039625 @default.
- W2116767120 hasConcept C529295009 @default.
- W2116767120 hasConcept C55493867 @default.
- W2116767120 hasConcept C71924100 @default.
- W2116767120 hasConcept C79879829 @default.
- W2116767120 hasConcept C85265743 @default.
- W2116767120 hasConcept C86803240 @default.
- W2116767120 hasConcept C87568996 @default.
- W2116767120 hasConcept C95444343 @default.
- W2116767120 hasConceptScore W2116767120C104317684 @default.
- W2116767120 hasConceptScore W2116767120C126322002 @default.
- W2116767120 hasConceptScore W2116767120C142724271 @default.
- W2116767120 hasConceptScore W2116767120C179264091 @default.
- W2116767120 hasConceptScore W2116767120C18903297 @default.
- W2116767120 hasConceptScore W2116767120C203014093 @default.
- W2116767120 hasConceptScore W2116767120C204232928 @default.
- W2116767120 hasConceptScore W2116767120C2777312293 @default.
- W2116767120 hasConceptScore W2116767120C4224716 @default.
- W2116767120 hasConceptScore W2116767120C49039625 @default.
- W2116767120 hasConceptScore W2116767120C529295009 @default.
- W2116767120 hasConceptScore W2116767120C55493867 @default.
- W2116767120 hasConceptScore W2116767120C71924100 @default.
- W2116767120 hasConceptScore W2116767120C79879829 @default.
- W2116767120 hasConceptScore W2116767120C85265743 @default.
- W2116767120 hasConceptScore W2116767120C86803240 @default.
- W2116767120 hasConceptScore W2116767120C87568996 @default.
- W2116767120 hasConceptScore W2116767120C95444343 @default.
- W2116767120 hasLocation W21167671201 @default.
- W2116767120 hasOpenAccess W2116767120 @default.
- W2116767120 hasPrimaryLocation W21167671201 @default.
- W2116767120 hasRelatedWork W1947441633 @default.
- W2116767120 hasRelatedWork W1991380396 @default.
- W2116767120 hasRelatedWork W2058122393 @default.
- W2116767120 hasRelatedWork W2081316178 @default.
- W2116767120 hasRelatedWork W2081934986 @default.
- W2116767120 hasRelatedWork W2101286472 @default.
- W2116767120 hasRelatedWork W2105335686 @default.
- W2116767120 hasRelatedWork W2141730517 @default.
- W2116767120 hasRelatedWork W2164501467 @default.
- W2116767120 hasRelatedWork W2165498827 @default.
- W2116767120 hasRelatedWork W2371747069 @default.
- W2116767120 hasRelatedWork W2382550299 @default.
- W2116767120 hasRelatedWork W2416238758 @default.
- W2116767120 hasRelatedWork W2576199970 @default.
- W2116767120 hasRelatedWork W2767345698 @default.
- W2116767120 hasRelatedWork W2982716214 @default.
- W2116767120 hasRelatedWork W3031857414 @default.
- W2116767120 hasRelatedWork W3043293846 @default.
- W2116767120 hasRelatedWork W3080885521 @default.
- W2116767120 hasRelatedWork W3127522351 @default.
- W2116767120 hasVolume "44" @default.
- W2116767120 isParatext "false" @default.
- W2116767120 isRetracted "false" @default.
- W2116767120 magId "2116767120" @default.
- W2116767120 workType "article" @default.