Matches in SemOpenAlex for { <https://semopenalex.org/work/W2116767253> ?p ?o ?g. }
- W2116767253 endingPage "10" @default.
- W2116767253 startingPage "1" @default.
- W2116767253 abstract "Extending the classical concept considering an imbalance exclusively of T helper(h) 1 and Th2 cells on the bottom of many inflammatory diseases, Th17 cells were recently described. Today, there is sufficient experimental evidence to classify psoriasis and allergic contact dermatitis (ACD) amongst other inflammatory skin disorders as IL-17 associated diseases. In several human studies, T-cell-clones could be isolated from eczema biopsies, and high IL-17 levels were observed after challenge with allergen. In the last years, the phenotype of these IL-17 releasing T cells was in the focus of discussion. It has been suggested that Th17 could be identified by expression of retinoic acid receptor-related orphan receptor (ROR)C (humans) or ROR γ t (mice) and IL-17, accompanied by the absence of IFN- γ and IL-22. In cells from skin biopsies, contact allergens elevate IL-17A, IL-23, and RORC within the subset of Th cells. The indications for a participation of Th17 in the development of ACD are supported by data from IL-17 deficient mice with reduced contact hypersensitivity (CHS) reactions that could be restored after transplantation of wild type CD4 + T cells. In addition to Th17 cells, subpopulations of CD8 + T cells and regulatory T cells are further sources of IL-17 that play important roles in ACD as well. Finally, the results from Th17 cell research allow today identification of different skin diseases by a specific profile of signature cytokines from Th cells that can be used as a future diagnostic tool." @default.
- W2116767253 created "2016-06-24" @default.
- W2116767253 creator A5081448983 @default.
- W2116767253 date "2013-01-01" @default.
- W2116767253 modified "2023-09-30" @default.
- W2116767253 title "Role of Th17 Cells in Skin Inflammation of Allergic Contact Dermatits" @default.
- W2116767253 cites W1483162601 @default.
- W2116767253 cites W1489934654 @default.
- W2116767253 cites W1562441478 @default.
- W2116767253 cites W1628375506 @default.
- W2116767253 cites W1651822094 @default.
- W2116767253 cites W1654356430 @default.
- W2116767253 cites W1661544713 @default.
- W2116767253 cites W1662168393 @default.
- W2116767253 cites W1751022716 @default.
- W2116767253 cites W1799978200 @default.
- W2116767253 cites W1840746127 @default.
- W2116767253 cites W1855741677 @default.
- W2116767253 cites W1897081658 @default.
- W2116767253 cites W1912634928 @default.
- W2116767253 cites W1915611502 @default.
- W2116767253 cites W1918925546 @default.
- W2116767253 cites W1942668068 @default.
- W2116767253 cites W1950444616 @default.
- W2116767253 cites W1963492948 @default.
- W2116767253 cites W1965731762 @default.
- W2116767253 cites W1966694580 @default.
- W2116767253 cites W1972847800 @default.
- W2116767253 cites W1976379219 @default.
- W2116767253 cites W1978329811 @default.
- W2116767253 cites W1980907070 @default.
- W2116767253 cites W1982926364 @default.
- W2116767253 cites W1983754832 @default.
- W2116767253 cites W1986938885 @default.
- W2116767253 cites W1987598047 @default.
- W2116767253 cites W1987628377 @default.
- W2116767253 cites W1989286818 @default.
- W2116767253 cites W1989552966 @default.
- W2116767253 cites W2002987322 @default.
- W2116767253 cites W2011644825 @default.
- W2116767253 cites W2016970487 @default.
- W2116767253 cites W2017046428 @default.
- W2116767253 cites W2018733478 @default.
- W2116767253 cites W2022076192 @default.
- W2116767253 cites W2024855291 @default.
- W2116767253 cites W2035602341 @default.
- W2116767253 cites W2042194530 @default.
- W2116767253 cites W2051605675 @default.
- W2116767253 cites W2054464533 @default.
- W2116767253 cites W2054684230 @default.
- W2116767253 cites W2063557216 @default.
- W2116767253 cites W2065136791 @default.
- W2116767253 cites W2065307318 @default.
- W2116767253 cites W2072503309 @default.
- W2116767253 cites W2074717986 @default.
- W2116767253 cites W2076397065 @default.
- W2116767253 cites W2076889715 @default.
- W2116767253 cites W2083210775 @default.
- W2116767253 cites W2083997617 @default.
- W2116767253 cites W2086410328 @default.
- W2116767253 cites W2088444832 @default.
- W2116767253 cites W2090640877 @default.
- W2116767253 cites W2091696903 @default.
- W2116767253 cites W2092894443 @default.
- W2116767253 cites W2093897672 @default.
- W2116767253 cites W2102158172 @default.
- W2116767253 cites W2102202702 @default.
- W2116767253 cites W2104904748 @default.
- W2116767253 cites W2111986891 @default.
- W2116767253 cites W2112133235 @default.
- W2116767253 cites W2114269157 @default.
- W2116767253 cites W2114656434 @default.
- W2116767253 cites W2114982159 @default.
- W2116767253 cites W2116068128 @default.
- W2116767253 cites W2116867036 @default.
- W2116767253 cites W2118773711 @default.
- W2116767253 cites W2120287519 @default.
- W2116767253 cites W2120815988 @default.
- W2116767253 cites W2123093300 @default.
- W2116767253 cites W2127724771 @default.
- W2116767253 cites W2130363359 @default.
- W2116767253 cites W2133765154 @default.
- W2116767253 cites W2138953449 @default.
- W2116767253 cites W2142070588 @default.
- W2116767253 cites W2147172932 @default.
- W2116767253 cites W2148044949 @default.
- W2116767253 cites W2149748445 @default.
- W2116767253 cites W2154137408 @default.
- W2116767253 cites W2156489752 @default.
- W2116767253 cites W2157508907 @default.
- W2116767253 cites W2157579285 @default.
- W2116767253 cites W2160258620 @default.
- W2116767253 cites W2160883911 @default.
- W2116767253 cites W2161889530 @default.
- W2116767253 cites W2162192690 @default.
- W2116767253 cites W2162970323 @default.
- W2116767253 cites W2169192341 @default.
- W2116767253 cites W2169979504 @default.