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• W2116768499 abstract "Objective : Overfeeding suppresses GH secretion and makes evaluation of a suspected GH deficiency (GHD) difficult. In normal weight subjects, gender is known to influence GH concentrations, which is most apparent in the ambulatory, morning-fasted state. In this study, we examined the GH/IGF-I axis in obese men and women and the effect of surgically induced weight loss. Design : Sixty-three subjects (body mass index (BMI) 45 ± 6 kg/m 2 ; 54 women, 9 men) were studied prior to, and 6 and 12 months following Roux-en-Y gastric bypass (RYGBP) surgery. Fifty-four patients with classic GHD (BMI 27 ± 6 kg/m 2 ; 35 men, 19 women) were included for comparison. Methods : Hormones were analysed in fasting morning serum samples. Results : RYGBP resulted in a decreased BMI to 35 ± kg/m 2 at 6 months and 32 ± 6 kg/m 2 at 12 months. GH and IGF-I increased at 6 months in the women and at 12 months in both sexes by ≥ 300 and 11% respectively. Prior to RYGBP, GH concentrations were low in the obese men and similar to those of GHD men (mean 0.09 mU/l). Obese women had tenfold higher values than obese men and sevenfold higher than GHD women. IGF-I levels were in the low reference range in the obese and below −2 s.d. for age in 13%. Conclusions : Surgically induced weight loss partially restores GH secretion. Despite a marked suppression of GH values, a gender influence is maintained in severe obesity. In obese women, single morning GH and IGF-I values seem sufficient to exclude a suspicion of classic GHD." @default.
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• W2116768499 date "2006-01-01" @default.
• W2116768499 modified "2023-10-14" @default.
• W2116768499 title "Effects of gastric bypass on the GH/IGF-I axis in severe obesity – and a comparison with GH deficiency" @default.
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• W2116768499 doi "https://doi.org/10.1530/eje.1.02069" @default.
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