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- W2116769190 abstract "Phage display screening allows the study of functional protein-protein interactions at the cell surface, but investigating intracellular organelles remains a challenge. Here we introduce internalizing-phage libraries to identify clones that enter mammalian cells through a receptor-independent mechanism and target-specific organelles as a tool to select ligand peptides and identify their intracellular receptors. We demonstrate that penetratin, an antennapedia-derived peptide, can be displayed on the phage envelope and mediate receptor-independent uptake of internalizing phage into cells. We also show that an internalizing-phage construct displaying an established mitochondria-specific localization signal targets mitochondria, and that an internalizing-phage random peptide library selects for peptide motifs that localize to different intracellular compartments. As a proof-of-concept, we demonstrate that one such peptide, if chemically fused to penetratin, is internalized receptor-independently, localizes to mitochondria, and promotes cell death. This combinatorial platform technology has potential applications in cell biology and drug development." @default.
- W2116769190 created "2016-06-24" @default.
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- W2116769190 date "2012-04-17" @default.
- W2116769190 modified "2023-09-23" @default.
- W2116769190 title "Combinatorial targeting and discovery of ligand-receptors in organelles of mammalian cells" @default.
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- W2116769190 doi "https://doi.org/10.1038/ncomms1773" @default.
- W2116769190 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3337985" @default.
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