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- W2116769389 abstract "Extended-spectrum β-lactamase-producing Enterobacteriaceae isolates (ESBLE) are emerging pathogens that confer resistance to antimicrobial drugs. We conducted a 10-year study in France (January 2001-April 2010) to investigate the incidence of and risk factors for ESBLE infections after liver transplant. Of 710 transplant patients screened preoperatively for ESBLE fecal carriage, 5.5% had ESBLE infection develop within 4 months after surgery; patients with pretransplant ESBLE fecal carriage were more likely to have infection develop than were noncarriers. Typing showed extensive genetic diversity, with a large predominance of CTX-M enzymes. Independent predictors of ESBLE infection were pretransplant fecal carriage, Model for End Stage Liver Disease score >25, and return to surgery. Our results indicate that the influx of preoperatively acquired ESBLE isolates into the hospital outweighs cross-transmission in the epidemiology of ESBLE infections after liver transplant. Transplant candidates should be systematically screened for carriage, and posttransplant infection in carriers should be treated with carbapenems." @default.
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- W2116769389 date "2012-06-01" @default.
- W2116769389 modified "2023-10-18" @default.
- W2116769389 title "Pretransplant Fecal Carriage of Extended-Spectrum β-Lactamase–producing<i>Enterobacteriaceae</i>and Infection after Liver Transplant, France" @default.
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- W2116769389 doi "https://doi.org/10.3201/eid1806.110139" @default.
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