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- W2116774907 abstract "Magnetic resonance imaging (MRI and single-photon emission computed tomography (SPECT) have a considerable role in the diagnosis of the single patient with movement disorders. Conventional MRI demonstrates symptomatic causes of parkinsonism but does not show any specific finding in Parkinson's disease (PD). However, SPECT using tracers of the dopamine transporter (DAT) demonstrates an asymmetric decrease of the uptake in the putamen and caudate from the earliest clinical stages. In other degenerative forms of parkinsonism, including progressive supranuclear palsy (PSP), multisystem atrophy (MSA), and corticobasal degeneration (CBD), MRI reveals characteristic patterns of regional atrophy combined with signal changes or microstructural changes in the basal ganglia, pons, middle and superior cerebellar peduncles, and cerebral subcortical white matter. SPECT demonstrates a decreased uptake of tracers of the dopamine D2 receptors in the striata of patients with PSP and MSA, which is not observed in early PD. MRI also significantly contributes to the diagnosis of some inherited hyperkinetic conditions including neurodegeneration with brain iron accumulation and fragile-X tremor/ataxia syndrome by revealing characteristic symmetric signal changes in the basal ganglia and middle cerebellar peduncles, respectively. A combination of the clinical features with MRI and SPECT is recommended for optimization of the diagnostic algorithm in movement disorders." @default.
- W2116774907 created "2016-06-24" @default.
- W2116774907 creator A5004852352 @default.
- W2116774907 creator A5061614117 @default.
- W2116774907 creator A5062640613 @default.
- W2116774907 date "2012-01-23" @default.
- W2116774907 modified "2023-10-10" @default.
- W2116774907 title "Movement disorders: role of imaging in diagnosis" @default.
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- W2116774907 doi "https://doi.org/10.1002/jmri.22825" @default.
- W2116774907 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22271273" @default.