Matches in SemOpenAlex for { <https://semopenalex.org/work/W2116775917> ?p ?o ?g. }
- W2116775917 abstract "Hepatocellular carcinoma (HCC) is the most common primary liver malignancy. Despite efforts for prevention and screening as well as development of new technologies for diagnosis and treatment, the incidence of HCC has doubled, and mortality rates have increased in recent decades. A variety of important risk factors are associated with the development of HCC, with any type of cirrhosis, regardless of etiology, being the major contributor. Hepatitis C virus infection with bridging fibrosis or cirrhosis and hepatitis B virus infection are independent risk factors. The diagnosis of HCC is made without liver biopsy in over 90% of cases. Screening with ultrasound and alpha-fetoprotein (AFP) at 6-month intervals is advised; however, it is not adequate for patients on the orthotopic liver transplantation (OLT) list. Triple-phase computed tomography and/or magnetic resonance imaging are used in combination with the detection of AFP, AFP-L3%, and/or des-gamma-carboxy prothrombin due to their superior sensitivities and specificities. Several treatment modalities are available, but only surgical resection and OLT are curative. OLT is available only for patients who meet or are downstaged into Milan or University of California, San Francisco criteria. Other treatment options include radiofrequency ablation, microwave ablation, percutaneous ethanol injection, transarterial chemoembolization, radioembolization, cryoablation, radiation therapy, stereotactic radiotherapy, systemic chemotherapy, and molecularly targeted therapies. The management of HCC is based on tumor size and location, extrahepatic spread, and underlying liver function. Given the complexity of the disease, patients are often best served in centers with experience in HCC management, where a multi-disciplinary approach can take place." @default.
- W2116775917 created "2016-06-24" @default.
- W2116775917 creator A5009446007 @default.
- W2116775917 creator A5072799463 @default.
- W2116775917 date "2014-03-01" @default.
- W2116775917 modified "2023-09-25" @default.
- W2116775917 title "Current management of hepatocellular carcinoma." @default.
- W2116775917 cites W1533272557 @default.
- W2116775917 cites W1964285405 @default.
- W2116775917 cites W1968439009 @default.
- W2116775917 cites W1969489445 @default.
- W2116775917 cites W1971837077 @default.
- W2116775917 cites W1973514550 @default.
- W2116775917 cites W1975154077 @default.
- W2116775917 cites W1980603418 @default.
- W2116775917 cites W1981989535 @default.
- W2116775917 cites W1982153769 @default.
- W2116775917 cites W1983947057 @default.
- W2116775917 cites W1987978415 @default.
- W2116775917 cites W1990073288 @default.
- W2116775917 cites W1991148026 @default.
- W2116775917 cites W1993166310 @default.
- W2116775917 cites W1994193851 @default.
- W2116775917 cites W1995180061 @default.
- W2116775917 cites W1998417832 @default.
- W2116775917 cites W1999421234 @default.
- W2116775917 cites W2000001318 @default.
- W2116775917 cites W2004261972 @default.
- W2116775917 cites W2008615142 @default.
- W2116775917 cites W2009988330 @default.
- W2116775917 cites W2017669411 @default.
- W2116775917 cites W2022169488 @default.
- W2116775917 cites W2022633334 @default.
- W2116775917 cites W2022770313 @default.
- W2116775917 cites W2023629303 @default.
- W2116775917 cites W2025890159 @default.
- W2116775917 cites W2026525583 @default.
- W2116775917 cites W2028667086 @default.
- W2116775917 cites W2033802014 @default.
- W2116775917 cites W2039621565 @default.
- W2116775917 cites W2039785925 @default.
- W2116775917 cites W2041833525 @default.
- W2116775917 cites W2042209473 @default.
- W2116775917 cites W2044018537 @default.
- W2116775917 cites W2047033934 @default.
- W2116775917 cites W2047554241 @default.
- W2116775917 cites W2056243205 @default.
- W2116775917 cites W2067273401 @default.
- W2116775917 cites W2070158817 @default.
- W2116775917 cites W2070245532 @default.
- W2116775917 cites W2070778756 @default.
- W2116775917 cites W2078114654 @default.
- W2116775917 cites W2081176013 @default.
- W2116775917 cites W2081669334 @default.
- W2116775917 cites W2085295387 @default.
- W2116775917 cites W2090293099 @default.
- W2116775917 cites W2092759077 @default.
- W2116775917 cites W2093584357 @default.
- W2116775917 cites W2094873643 @default.
- W2116775917 cites W2095977252 @default.
- W2116775917 cites W2096808350 @default.
- W2116775917 cites W2102240822 @default.
- W2116775917 cites W2103723243 @default.
- W2116775917 cites W2105121109 @default.
- W2116775917 cites W2109820748 @default.
- W2116775917 cites W2121707384 @default.
- W2116775917 cites W2125763116 @default.
- W2116775917 cites W2126196500 @default.
- W2116775917 cites W2126621933 @default.
- W2116775917 cites W2131357269 @default.
- W2116775917 cites W2132449054 @default.
- W2116775917 cites W2138610774 @default.
- W2116775917 cites W2145788008 @default.
- W2116775917 cites W2147172608 @default.
- W2116775917 cites W2154239359 @default.
- W2116775917 cites W2154605870 @default.
- W2116775917 cites W2158585862 @default.
- W2116775917 cites W2161670004 @default.
- W2116775917 cites W2161817637 @default.
- W2116775917 cites W2163403599 @default.
- W2116775917 cites W2163486683 @default.
- W2116775917 cites W2165933819 @default.
- W2116775917 cites W2169874604 @default.
- W2116775917 cites W2181943631 @default.
- W2116775917 cites W2213448039 @default.
- W2116775917 cites W2277004004 @default.
- W2116775917 cites W2315027248 @default.
- W2116775917 cites W2320599978 @default.
- W2116775917 cites W2325575463 @default.
- W2116775917 cites W2330134488 @default.
- W2116775917 cites W2403190918 @default.
- W2116775917 cites W2418708864 @default.
- W2116775917 cites W34245556 @default.
- W2116775917 cites W347032968 @default.
- W2116775917 cites W50269869 @default.
- W2116775917 cites W3145895499 @default.
- W2116775917 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4014047" @default.
- W2116775917 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24829542" @default.
- W2116775917 hasPublicationYear "2014" @default.
- W2116775917 type Work @default.