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• W2116778122 abstract "K+ channels are highly selective for K+ over Na+. Here we present several crystal structures of the MthK K+ channel pore at up to 1.45-A resolution. The MthK selectivity filter maintains a conductive conformation even in the absence of K+, allowing the channel to conduct Na+. The high-resolution structures, along with single-channel recordings, allow for an accurate analysis of how K+ competes with Na+ in a conductive selectivity filter. At high K+ concentrations, two K+ ions equivalently occupy the four sites in the selectivity filter, whereas at low K+/high Na+ concentrations, a single K+ ion remains bound in the selectivity filter, preferably at site 1 or site 3. This single K+ binding at low concentration effectively blocks the permeation of Na+, providing a structural basis for the anomalous mole-fraction effect, a key property of multi-ion pores." @default.
• W2116778122 created "2016-06-24" @default.
• W2116778122 creator A5048201154 @default.
• W2116778122 creator A5064842058 @default.
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• W2116778122 date "2010-08-01" @default.
• W2116778122 modified "2023-09-30" @default.
• W2116778122 title "Novel insights into K+ selectivity from high-resolution structures of an open K+ channel pore" @default.
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• W2116778122 doi "https://doi.org/10.1038/nsmb.1865" @default.
• W2116778122 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2918291" @default.
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