FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2116779104> ?p ?o ?g. }

• W2116779104 endingPage "1318" @default.
• W2116779104 startingPage "1313" @default.
• W2116779104 abstract "2'-beta-Fluoro-2',3'-dideoxyadenosine (F-ddA) is an acid-stable purine dideoxynucleoside analog active against a wide spectrum of human immunodeficiency virus type 1 (HIV-1) and HIV-2 strains in vitro. F-ddA is presently undergoing a phase I clinical trial at the National Cancer Institute. We induced HIV-1 variants resistant to F-ddA by exposing wild-type HIV-1 (HIV-1LAI) to increasing concentrations of F-ddA in vitro. After 18 passages, the virus was fourfold less sensitive to F-ddA than HIV-1LAI. Sequence analyses of the passage 18 virus revealed changes in three amino acids in the reverse transcriptase (RT)-encoding region of the pol gene: P to S at codon 119 (P119S; present in 3 of 13 and 28 of 28 molecular clones before and after F-ddA exposure, respectively), V179D (0 of 13 and 9 of 28, respectively), and L214F (9 of 13 and 28 of 28, respectively). Drug sensitivity assays using recombinant infectious clones confirmed that P119S was directly responsible for the reduced sensitivity of HIV-1 to F-ddA. Various infectious clones with single or multiple amino acid substitutions conferring viral resistance against nucleoside RT inhibitors, including HIV-1 variants with multi-dideoxynucleoside resistance, were generally sensitive to F-ddA. The moderate level of resistance of HIV-1 to F-ddA, together with the lack of conferment of significant cross-resistance by the F-ddA-associated amino acid substitutions, warrants further investigation of F-ddA as a potential antiviral agent for use in treatment of HIV-1 infection." @default.
• W2116779104 created "2016-06-24" @default.
• W2116779104 creator A5019188342 @default.
• W2116779104 creator A5023159610 @default.
• W2116779104 creator A5034448543 @default.
• W2116779104 creator A5039425264 @default.
• W2116779104 creator A5051668188 @default.
• W2116779104 creator A5069707790 @default.
• W2116779104 creator A5076337697 @default.
• W2116779104 creator A5089996238 @default.
• W2116779104 date "1997-06-01" @default.
• W2116779104 modified "2023-10-14" @default.
• W2116779104 title "In vitro induction of human immunodeficiency virus type 1 variants resistant to 2'-beta-Fluoro-2',3'-dideoxyadenosine" @default.
• W2116779104 cites W1495565347 @default.
• W2116779104 cites W1562770126 @default.
• W2116779104 cites W1665723380 @default.
• W2116779104 cites W1945870172 @default.
• W2116779104 cites W1963967933 @default.
• W2116779104 cites W1966200141 @default.
• W2116779104 cites W1985977968 @default.
• W2116779104 cites W2005441621 @default.
• W2116779104 cites W2008428638 @default.
• W2116779104 cites W2008954911 @default.
• W2116779104 cites W2014890179 @default.
• W2116779104 cites W2019065325 @default.
• W2116779104 cites W2022314336 @default.
• W2116779104 cites W2025434215 @default.
• W2116779104 cites W2026323517 @default.
• W2116779104 cites W2028143521 @default.
• W2116779104 cites W2042714313 @default.
• W2116779104 cites W2044864734 @default.
• W2116779104 cites W2048134214 @default.
• W2116779104 cites W2051655276 @default.
• W2116779104 cites W2057227263 @default.
• W2116779104 cites W2064945443 @default.
• W2116779104 cites W2067267322 @default.
• W2116779104 cites W2070102958 @default.
• W2116779104 cites W2086462809 @default.
• W2116779104 cites W2086613804 @default.
• W2116779104 cites W2106603936 @default.
• W2116779104 cites W2119997930 @default.
• W2116779104 cites W2124217674 @default.
• W2116779104 cites W2127518061 @default.
• W2116779104 cites W2156152306 @default.
• W2116779104 cites W2163138000 @default.
• W2116779104 cites W2318294116 @default.
• W2116779104 cites W2472309156 @default.
• W2116779104 cites W2917003203 @default.
• W2116779104 doi "https://doi.org/10.1128/aac.41.6.1313" @default.
• W2116779104 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/163906" @default.
• W2116779104 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9174190" @default.
• W2116779104 hasPublicationYear "1997" @default.
• W2116779104 type Work @default.
• W2116779104 sameAs 2116779104 @default.
• W2116779104 citedByCount "26" @default.
• W2116779104 countsByYear W21167791042014 @default.
• W2116779104 crossrefType "journal-article" @default.
• W2116779104 hasAuthorship W2116779104A5019188342 @default.
• W2116779104 hasAuthorship W2116779104A5023159610 @default.
• W2116779104 hasAuthorship W2116779104A5034448543 @default.
• W2116779104 hasAuthorship W2116779104A5039425264 @default.
• W2116779104 hasAuthorship W2116779104A5051668188 @default.
• W2116779104 hasAuthorship W2116779104A5069707790 @default.
• W2116779104 hasAuthorship W2116779104A5076337697 @default.
• W2116779104 hasAuthorship W2116779104A5089996238 @default.
• W2116779104 hasBestOaLocation W21167791041 @default.
• W2116779104 hasConcept C104317684 @default.
• W2116779104 hasConcept C114851261 @default.
• W2116779104 hasConcept C156719811 @default.
• W2116779104 hasConcept C159047783 @default.
• W2116779104 hasConcept C202751555 @default.
• W2116779104 hasConcept C2522874641 @default.
• W2116779104 hasConcept C2776543447 @default.
• W2116779104 hasConcept C40767141 @default.
• W2116779104 hasConcept C515207424 @default.
• W2116779104 hasConcept C54355233 @default.
• W2116779104 hasConcept C67705224 @default.
• W2116779104 hasConcept C86803240 @default.
• W2116779104 hasConceptScore W2116779104C104317684 @default.
• W2116779104 hasConceptScore W2116779104C114851261 @default.
• W2116779104 hasConceptScore W2116779104C156719811 @default.
• W2116779104 hasConceptScore W2116779104C159047783 @default.
• W2116779104 hasConceptScore W2116779104C202751555 @default.
• W2116779104 hasConceptScore W2116779104C2522874641 @default.
• W2116779104 hasConceptScore W2116779104C2776543447 @default.
• W2116779104 hasConceptScore W2116779104C40767141 @default.
• W2116779104 hasConceptScore W2116779104C515207424 @default.
• W2116779104 hasConceptScore W2116779104C54355233 @default.
• W2116779104 hasConceptScore W2116779104C67705224 @default.
• W2116779104 hasConceptScore W2116779104C86803240 @default.
• W2116779104 hasIssue "6" @default.
• W2116779104 hasLocation W21167791041 @default.
• W2116779104 hasLocation W21167791042 @default.
• W2116779104 hasLocation W21167791043 @default.
• W2116779104 hasLocation W21167791044 @default.
• W2116779104 hasOpenAccess W2116779104 @default.
• W2116779104 hasPrimaryLocation W21167791041 @default.
• W2116779104 hasRelatedWork W1487857142 @default.

• next