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• W2116779839 abstract "Abstract The progressive decline in HIV mortality in western countries over the past 5 to 10 years is due in large part to the clinical effectiveness of combination antiviral therapy using nucleoside and non-nucleoside reverse transcriptase inhibitors and protease inhibitors. Combination therapy failures are not uncommon, though, and are due to multiple factors, including poor compliance, sub-optimal drug pharmacokinetics, the evolution of resistant virus, or initial infection with a resistant virus. Laboratory assays have been developed to detect HIV-1 drug resistance and in several prospective randomized clinical trials have been shown to effectively assist in choosing optimal drug regimens for specific patients. In the setting of treatment failure, drug resistance testing for HIV-1-infected patients is now considered standard of care. Two basic types of assays are in use: (i) phenotype tests that determine quantitatively the susceptibilities of HIV-1 strains cultured from infected patients to a panel of drugs and (ii) genotype testing that involves sequence analysis of the viral reverse transcriptase and protease genes to identify mutations known to mediate resistance. The roles and relative advantages of these tests will be discussed." @default.
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• W2116779839 date "2004-03-01" @default.
• W2116779839 modified "2023-09-27" @default.
• W2116779839 title "Clinical testing for HIV-1 drug resistance" @default.
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• W2116779839 doi "https://doi.org/10.1016/s0196-4399(04)90015-3" @default.
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