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• W2116780023 abstract "Novel therapeutic agents and strategies have been introduced into the management of myelodysplastic syndromes (MDS) in the last years. This has led to more treatment options and a better chance of long-term survival for MDS patients, but also to uncertainty regarding the optimal use and possible side effects of these treatments. The Italian Society of Hematology commissioned a project to develop guidelines for the therapy of MDS using evidence-based knowledge and consensus-formation techniques.An Advisory Council (AC) shaped the project around a series of key clinical questions, performed a systematic search for evidence and graded the available evidence according to the Scottish Intercollegiate Guidelines Network (SIGN). A list of clinical questions was mailed to each of 10 senior hematologists composing the Expert Panel (EP): the panelists were asked to rank the most relevant questions, and to formulate answers to the questions according to the tables of evidence. A scenario phase followed, so as to reach a consensus on the three top ranked questions. The EP was asked to score patient profiles as appropriate or not appropriate for the therapeutic strategy under scrutiny, according to the RAND technique. Finally, from September 2001 to January 2002, four Consensus Conferences conducted according to the Nominal Group Technique were held in Milan, Italy. The overall goal of the conferences was to take a final decision upon the appropriateness of the uncertain scenarios and of the uncertain responses to the clinical questions.Evidence was judged sufficient for providing recommendations on the use of allogeneic stem cell transplantation, leukemia-like chemotherapy, autologous stem cell transplantation, low-dose chemotherapy, danazol, immunosuppressive therapy, hypomethylating agents and hematopoietic growth factors. Specific recommendations for supportive therapy, including iron chelation, were issued. Allogeneic stem cell transplantation was unanimously considered as the only curative treatment for MDS patients, and recommendations on its use were agreed based on patient's age, risk, clinical features and donor availability. AML-like chemotherapy was also considered a valuable therapeutic option for subsets of MDS patients. Autologous stem cell transplantation was recommended for patients who lack an HLA identical donor and have achieved complete remission with AML-like chemotherapy. Decitabine, recombinant human erythropoietin and immunosuppressive therapy were judged valuable therapeutic options for subsets of MDS patients whereas low-dose cytarabine was not. Specific therapeutic strategies for those subjects younger than 18 years or older than 75 years and the strategy of watchful waiting were decided by patient-oriented questions.Using evidence and consensus, recommendations for the treatment of MDS were issued. Statements were graded according to the strength of the supporting evidence and uncertainty was explicitly declared." @default.
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• W2116780023 date "2002-12-01" @default.
• W2116780023 modified "2023-09-27" @default.
• W2116780023 title "Evidence- and consensus-based practice guidelines for the therapy of primary myelodysplastic syndromes. A statement from the Italian Society of Hematology." @default.
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• W2116780023 cites W1711791220 @default.
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• W2116780023 cites W1977285287 @default.
• W2116780023 cites W1979820704 @default.
• W2116780023 cites W1983781920 @default.
• W2116780023 cites W1983819513 @default.
• W2116780023 cites W1991125854 @default.
• W2116780023 cites W1998688881 @default.
• W2116780023 cites W2004227612 @default.
• W2116780023 cites W2025394831 @default.
• W2116780023 cites W2027790986 @default.
• W2116780023 cites W2030215141 @default.
• W2116780023 cites W2033588533 @default.
• W2116780023 cites W2035180118 @default.
• W2116780023 cites W2045507683 @default.
• W2116780023 cites W2052480622 @default.
• W2116780023 cites W2055101497 @default.
• W2116780023 cites W2069566335 @default.
• W2116780023 cites W2078790776 @default.
• W2116780023 cites W2085436951 @default.
• W2116780023 cites W2089889400 @default.
• W2116780023 cites W2091703907 @default.
• W2116780023 cites W2099384791 @default.
• W2116780023 cites W2100714931 @default.
• W2116780023 cites W2102299347 @default.
• W2116780023 cites W2106584820 @default.
• W2116780023 cites W2110161049 @default.
• W2116780023 cites W2117291755 @default.
• W2116780023 cites W2117327010 @default.
• W2116780023 cites W2124569538 @default.
• W2116780023 cites W2126618177 @default.
• W2116780023 cites W2132262853 @default.
• W2116780023 cites W2147530468 @default.
• W2116780023 cites W2166690644 @default.
• W2116780023 cites W2278599555 @default.
• W2116780023 cites W2297773874 @default.
• W2116780023 cites W2304853137 @default.
• W2116780023 cites W2314192225 @default.
• W2116780023 cites W2314606814 @default.
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