FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2116780642> ?p ?o ?g. }

• W2116780642 endingPage "2351" @default.
• W2116780642 startingPage "2343" @default.
• W2116780642 abstract "Parkinson's disease-associated α-synuclein is an amyloidogenic protein not only expressed in the cytoplasm of neurons, but also secreted in the extracellular space and internalized into glial cells through a lipid raft-dependent process. We previously showed that α-synuclein interacts with raft glycosphingolipids through a structural motif common to various viral and amyloidogenic proteins. Here we report that α-synuclein also interacts with cholesterol, as assessed by surface pressure measurements of cholesterol-containing monolayers. Using a panel of recombinant fragments and synthetic peptides, we identified two distinct cholesterol-binding domains in α-synuclein. One of these domains, which corresponds to the tilted peptide of α-synuclein (67–78), bound cholesterol with high affinity and was toxic for cultured astrocytes. Molecular modeling suggested that cholesterol binds to this peptide with a tilt angle of 46°. α-synuclein also contains a cholesterol recognition consensus motif, which had a lower affinity for cholesterol and was devoid of toxicity. This motif is encased in the glycosphingolipid-binding domain (34–45) of α-synuclein. In raft-like model membranes containing both cholesterol and glycosphingolipids, the head groups of glycosphingolipids prevented the accessibility of cholesterol to exogenous ligands. Nevertheless, cholesterol appeared to ‘signal’ its presence by tuning glycosphingolipid conformation, thereby facilitating α-synuclein binding to raft-like membranes. We propose that the association of α-synuclein with lipid rafts involves both the binding of α-synuclein (34–45) to glycosphingolipids, and the interaction of the fusogenic tilted peptide (67–78) with cholesterol. Coincidentally, a similar mechanism is used by viruses (HIV-1, HTLV-I, Ebola) which display a tilted peptide and fuse with host cell membranes through a sphingolipid/cholesterol-dependent process." @default.
• W2116780642 created "2016-06-24" @default.
• W2116780642 creator A5037502530 @default.
• W2116780642 creator A5047254221 @default.
• W2116780642 creator A5062841099 @default.
• W2116780642 date "2011-10-01" @default.
• W2116780642 modified "2023-10-16" @default.
• W2116780642 title "The fusogenic tilted peptide (67–78) of α-synuclein is a cholesterol binding domain" @default.
• W2116780642 cites W1873189947 @default.
• W2116780642 cites W1967778765 @default.
• W2116780642 cites W1981151214 @default.
• W2116780642 cites W1981426567 @default.
• W2116780642 cites W1981671135 @default.
• W2116780642 cites W1986050360 @default.
• W2116780642 cites W2003681003 @default.
• W2116780642 cites W2010786308 @default.
• W2116780642 cites W2018398997 @default.
• W2116780642 cites W2018414196 @default.
• W2116780642 cites W2018506106 @default.
• W2116780642 cites W2020796799 @default.
• W2116780642 cites W2026676471 @default.
• W2116780642 cites W2027203404 @default.
• W2116780642 cites W2032842463 @default.
• W2116780642 cites W2032994693 @default.
• W2116780642 cites W2033776678 @default.
• W2116780642 cites W2037584614 @default.
• W2116780642 cites W2043544656 @default.
• W2116780642 cites W2043855224 @default.
• W2116780642 cites W2043864366 @default.
• W2116780642 cites W2048055598 @default.
• W2116780642 cites W2049737588 @default.
• W2116780642 cites W204986894 @default.
• W2116780642 cites W2050407809 @default.
• W2116780642 cites W2053128102 @default.
• W2116780642 cites W2057835051 @default.
• W2116780642 cites W2060464351 @default.
• W2116780642 cites W2066780104 @default.
• W2116780642 cites W2067132703 @default.
• W2116780642 cites W2074085543 @default.
• W2116780642 cites W2076019198 @default.
• W2116780642 cites W2087086208 @default.
• W2116780642 cites W2089900719 @default.
• W2116780642 cites W2091947935 @default.
• W2116780642 cites W2094152897 @default.
• W2116780642 cites W2101097950 @default.
• W2116780642 cites W2102537321 @default.
• W2116780642 cites W2108605108 @default.
• W2116780642 cites W2124209549 @default.
• W2116780642 cites W2129146981 @default.
• W2116780642 cites W2130050860 @default.
• W2116780642 cites W2131522485 @default.
• W2116780642 cites W2139171197 @default.
• W2116780642 cites W2143250368 @default.
• W2116780642 cites W2147461093 @default.
• W2116780642 cites W2155477793 @default.
• W2116780642 cites W2156182155 @default.
• W2116780642 cites W2156842609 @default.
• W2116780642 cites W2163972427 @default.
• W2116780642 cites W271071775 @default.
• W2116780642 cites W45634013 @default.
• W2116780642 doi "https://doi.org/10.1016/j.bbamem.2011.06.017" @default.
• W2116780642 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21756873" @default.
• W2116780642 hasPublicationYear "2011" @default.
• W2116780642 type Work @default.
• W2116780642 sameAs 2116780642 @default.
• W2116780642 citedByCount "105" @default.
• W2116780642 countsByYear W21167806422012 @default.
• W2116780642 countsByYear W21167806422013 @default.
• W2116780642 countsByYear W21167806422014 @default.
• W2116780642 countsByYear W21167806422015 @default.
• W2116780642 countsByYear W21167806422016 @default.
• W2116780642 countsByYear W21167806422017 @default.
• W2116780642 countsByYear W21167806422018 @default.
• W2116780642 countsByYear W21167806422019 @default.
• W2116780642 countsByYear W21167806422020 @default.
• W2116780642 countsByYear W21167806422021 @default.
• W2116780642 countsByYear W21167806422022 @default.
• W2116780642 countsByYear W21167806422023 @default.
• W2116780642 crossrefType "journal-article" @default.
• W2116780642 hasAuthorship W2116780642A5037502530 @default.
• W2116780642 hasAuthorship W2116780642A5047254221 @default.
• W2116780642 hasAuthorship W2116780642A5062841099 @default.
• W2116780642 hasBestOaLocation W21167806421 @default.
• W2116780642 hasConcept C12554922 @default.
• W2116780642 hasConcept C15920480 @default.
• W2116780642 hasConcept C178790620 @default.
• W2116780642 hasConcept C185592680 @default.
• W2116780642 hasConcept C2776931407 @default.
• W2116780642 hasConcept C2778163477 @default.
• W2116780642 hasConcept C2779281246 @default.
• W2116780642 hasConcept C41625074 @default.
• W2116780642 hasConcept C51639874 @default.
• W2116780642 hasConcept C521977710 @default.
• W2116780642 hasConcept C55493867 @default.
• W2116780642 hasConcept C79266657 @default.
• W2116780642 hasConcept C86803240 @default.
• W2116780642 hasConcept C9132879 @default.
• W2116780642 hasConcept C95444343 @default.

• next