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• W2116785478 abstract "Abstract Progesterone, produced by follicular cells, induces Xenopus laevis oocyte maturation through a very early event that inhibits the activity of the adenylyl cyclase effector system. The participation of a G‐protein has been implicated, based on the fact that the inhibitory effect of the steroid is GTP‐dependent, and it has been proposed that progesterone acts interfering with Gαs function at the plasma membrane. Here we investigate whether the change in oocyte Gαs levels affects the maturation process induced by progesterone. Overexpression of X. laevis wild type (wt) Gαs and the constitutive activated Gαs(QL) mutant, both blocked progesterone‐induced maturation, Gαs(QL) being much more effective than the wt protein. On the other hand, depletion of Gαs, by the use of antisense oligonucleotides, caused spontaneous maturation measured as MAPK activation, indicating clearly that the presence of Gαs is necessary to keep oocytes arrested. Overexpression of three different G‐protein coupled receptors (GPCR), the β2‐adrenergic receptor and the m4 and m5 muscarinic receptors, all caused inhibition of MAPK activation induced by progesterone. These receptors, upon their activation with the respective ligands, might be inducing the release of Gβγ from their respective Gα, which together with endogenous Gαs‐GTP, activate adenylyl cyclase. Our results indicate that Gαs plays an important role in the maturation process and support previous findings of Gβγ participation, suggesting the presence of a mechanism where a constitutively activated Gαs subunit, together with the Gβγ heterodimer, both maintain high levels of intracellular cAMP levels, blocking the G2/M transition. Mol. Reprod. Dev. 63: 104–109, 2002. © 2002 Wiley‐Liss, Inc." @default.
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• W2116785478 date "2002-07-23" @default.
• W2116785478 modified "2023-10-09" @default.
• W2116785478 title "Gαs levels regulate<i>Xenopus laevis</i>oocyte maturation" @default.
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• W2116785478 doi "https://doi.org/10.1002/mrd.10150" @default.
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