FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2116789361> ?p ?o ?g. }

• W2116789361 endingPage "2469" @default.
• W2116789361 startingPage "2456" @default.
• W2116789361 abstract "Agonist-stimulated internalization followed by recycling to the cell membrane play an important role in fine-tuning the activity of chemokine receptors. Because the recycling of chemokine receptors is critical for the reestablishment of the cellular responsiveness to ligand, it is crucial to understand the mechanisms underlying the receptor recycling and resensitization. In the present study, we have demonstrated that the chemokine receptor CXCR2 associated with myosin Vb and Rab11-family interacting protein 2 (FIP2) in a ligand-dependent manner. Truncation of the C-terminal domain of the receptor did not affect the association, suggesting that the interactions occur upstream of the C terminus of CXCR2. After ligand stimulation, the internalized CXCR2 colocalized with myosin Vb and Rab11-FIP2 in Rab11a-positive vesicles. The colocalization lasted for ∼2 h, and little colocalization was observed after 4 h of ligand stimulation. CXCR2 also colocalized with myosin Vb tail or Rab11-FIP2 (129–512), the N-terminal–truncated mutants of myosin Vb and Rab11-FIP2, respectively, but in a highly condensed manner. Expression of the enhanced green fluorescent protein-tagged myosin Vb tail significantly retarded the recycling and resensitization of CXCR2. CXCR2 recycling was also reduced by the expression Rab11-FIP2 (129–512). Moreover, expression of the myosin Vb tail reduced CXCR2- and CXCR4-mediated chemotaxis. These data indicate that Rab11-FIP2 and myosin Vb regulate CXCR2 recycling and receptor-mediated chemotaxis and that passage of internalized CXCR2 through Rab11a-positive recycling system is critical for physiological response to a chemokine." @default.
• W2116789361 created "2016-06-24" @default.
• W2116789361 creator A5010236925 @default.
• W2116789361 creator A5010542605 @default.
• W2116789361 creator A5011325117 @default.
• W2116789361 creator A5039270943 @default.
• W2116789361 creator A5050517398 @default.
• W2116789361 date "2004-05-01" @default.
• W2116789361 modified "2023-09-26" @default.
• W2116789361 title "Rab11-Family Interacting Protein 2 and Myosin Vb Are Required for CXCR2 Recycling and Receptor-mediated Chemotaxis" @default.
• W2116789361 cites W147102809 @default.
• W2116789361 cites W1507084693 @default.
• W2116789361 cites W1512080499 @default.
• W2116789361 cites W1549347261 @default.
• W2116789361 cites W1594083527 @default.
• W2116789361 cites W1600813584 @default.
• W2116789361 cites W1607898595 @default.
• W2116789361 cites W1612149354 @default.
• W2116789361 cites W1647554332 @default.
• W2116789361 cites W1800554228 @default.
• W2116789361 cites W1914608393 @default.
• W2116789361 cites W1963899806 @default.
• W2116789361 cites W1964626085 @default.
• W2116789361 cites W1974065711 @default.
• W2116789361 cites W1979669507 @default.
• W2116789361 cites W1982137523 @default.
• W2116789361 cites W1983377532 @default.
• W2116789361 cites W1987065451 @default.
• W2116789361 cites W2001044562 @default.
• W2116789361 cites W2003445673 @default.
• W2116789361 cites W2005400238 @default.
• W2116789361 cites W2005659566 @default.
• W2116789361 cites W2011970960 @default.
• W2116789361 cites W2013857696 @default.
• W2116789361 cites W2015836019 @default.
• W2116789361 cites W2020631983 @default.
• W2116789361 cites W2022387762 @default.
• W2116789361 cites W2025481401 @default.
• W2116789361 cites W2034948050 @default.
• W2116789361 cites W2039378135 @default.
• W2116789361 cites W2041097342 @default.
• W2116789361 cites W2043822229 @default.
• W2116789361 cites W2052467519 @default.
• W2116789361 cites W2055200188 @default.
• W2116789361 cites W2064352321 @default.
• W2116789361 cites W2081769332 @default.
• W2116789361 cites W2082863657 @default.
• W2116789361 cites W2083985288 @default.
• W2116789361 cites W2086324605 @default.
• W2116789361 cites W2091576523 @default.
• W2116789361 cites W2094813666 @default.
• W2116789361 cites W2101158532 @default.
• W2116789361 cites W2105291099 @default.
• W2116789361 cites W2108214331 @default.
• W2116789361 cites W2117302027 @default.
• W2116789361 cites W2119214706 @default.
• W2116789361 cites W2143408828 @default.
• W2116789361 cites W2146443631 @default.
• W2116789361 cites W2147169218 @default.
• W2116789361 cites W2154319486 @default.
• W2116789361 cites W2156323704 @default.
• W2116789361 cites W2160262946 @default.
• W2116789361 cites W2165244186 @default.
• W2116789361 cites W2169685486 @default.
• W2116789361 cites W2323027157 @default.
• W2116789361 cites W40039454 @default.
• W2116789361 cites W4313341476 @default.
• W2116789361 cites W4313422313 @default.
• W2116789361 cites W97158386 @default.
• W2116789361 doi "https://doi.org/10.1091/mbc.e03-09-0706" @default.
• W2116789361 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/404037" @default.
• W2116789361 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15004234" @default.
• W2116789361 hasPublicationYear "2004" @default.
• W2116789361 type Work @default.
• W2116789361 sameAs 2116789361 @default.
• W2116789361 citedByCount "139" @default.
• W2116789361 countsByYear W21167893612012 @default.
• W2116789361 countsByYear W21167893612013 @default.
• W2116789361 countsByYear W21167893612014 @default.
• W2116789361 countsByYear W21167893612015 @default.
• W2116789361 countsByYear W21167893612016 @default.
• W2116789361 countsByYear W21167893612017 @default.
• W2116789361 countsByYear W21167893612018 @default.
• W2116789361 countsByYear W21167893612019 @default.
• W2116789361 countsByYear W21167893612020 @default.
• W2116789361 countsByYear W21167893612021 @default.
• W2116789361 countsByYear W21167893612022 @default.
• W2116789361 countsByYear W21167893612023 @default.
• W2116789361 crossrefType "journal-article" @default.
• W2116789361 hasAuthorship W2116789361A5010236925 @default.
• W2116789361 hasAuthorship W2116789361A5010542605 @default.
• W2116789361 hasAuthorship W2116789361A5011325117 @default.
• W2116789361 hasAuthorship W2116789361A5039270943 @default.
• W2116789361 hasAuthorship W2116789361A5050517398 @default.
• W2116789361 hasBestOaLocation W21167893612 @default.
• W2116789361 hasConcept C12823836 @default.
• W2116789361 hasConcept C13373296 @default.
• W2116789361 hasConcept C135285700 @default.

• next