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• W2116790050 abstract "Objective To determine the association between body mass index (BMI), serum prostate-specific antigen (PSA) level and PSA density (PSAD) in patients with an elevated serum PSA level but a negative prostate biopsy. Methods This retrospective study enrolled men with a negative prostate biopsy but a serum PSA level of 3.0–10 ng/ml. All men underwent anthropometric measurements, serum PSA determination and transrectal ultrasound examination. BMI was grouped according to the Asia-Pacific obesity criteria: nonobese (<25 kg/m 2 ) versus obese (≥25 kg/m 2 ). Partial correlation and linear regression models between PSA, PSAD and BMI were conducted after adjusting for age. Results A total of 907 men were enrolled in this study. On multivariate analyses, PSA showed no significant correlation with age or BMI, whereas PSAD had a negative correlation with age and BMI. Similar results were obtained when patients were categorized as having low (3.0 < PSA ≤ 6.5 ng/ml) or high PSA (6.5 < PSA ≤ 10.0 ng/ml) levels. Conclusion PSAD, but not PSA, demonstrated a significant negative correlation with BMI. This indicates that a new strategy including PSAD rather than simple PSA levels should be adopted in the study of obesity-adjusted PSA cut-offs." @default.
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• W2116790050 date "2014-04-17" @default.
• W2116790050 modified "2023-10-17" @default.
• W2116790050 title "Association between obesity, prostate-specific antigen level and prostate-specific antigen density in men with a negative prostate biopsy" @default.
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• W2116790050 doi "https://doi.org/10.1177/0300060513518038" @default.
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