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• W2116791122 abstract "Introduction: Gamma-hydroxybutyrate (GHB) is a short-chain fatty acid that is synthesized within the CNS, mostly from its parent compound gamma amino butyric acid (GABA). GHB acts as a neuromodulator/neurotransmitter to affect neuronal activity of other neurotransmitters and so, stimulate the release of growth hormone. Its sodium salt (sodium oxybate: SXB) was approved by the Food and Drug Administration (FDA) for the treatment of narcolepsy. SXB has shown to improve disrupted sleep and increase NR3 (slow-wave restorative) sleep in patients with narcolepsy. It is rapidly absorbed and has a plasma half-life of 30 – 60 min, necessitating twice-nightly dosing. Most of the observed effects of SXB result from binding to GABA-B receptors. Areas covered: Several randomized, controlled trials demonstrated significantly improved fibromyalgia (FM) symptoms with SXB. As seen in narcolepsy trials, SXB improved sleep of FM patients, increased slow-wave sleep duration as well as delta power, and reduced frequent night-time awakenings. Furthermore, FM pain and fatigue was consistently reduced with nightly SXB over time. Commonly reported adverse events included headache, nausea, dizziness and somnolence. Despite its proven efficacy, SXB did not receive FDA approval for the management of FM in 2010, mostly because of concerns about abuse. Expert opinion: Insomnia, fatigue and pain are important clinical FM symptoms that showed moderate improvements with SXB in several large, well-designed clinical trials. Because of the limited efficacy of currently available FM drugs additional treatment options are needed. In particular, drugs like SXB – which belong to a different drug class than other Food and Drug Administration (FDA)-approved FM medications such as pregabalin, duloxetine and milnacipran – would provide a much-needed addition to presently available treatment options. However, the FDA has set the bar high for future SXB re-submissions, with requirements of superior efficacy and improved risk mitigation strategies. At this time, no future FDA submission of SXB for the fibromyalgia indication is planned." @default.
• W2116791122 created "2016-06-24" @default.
• W2116791122 creator A5019704861 @default.
• W2116791122 date "2011-06-16" @default.
• W2116791122 modified "2023-10-14" @default.
• W2116791122 title "Sodium oxybate for the treatment of fibromyalgia" @default.
• W2116791122 cites W106360673 @default.
• W2116791122 cites W1507101717 @default.
• W2116791122 cites W157052639 @default.
• W2116791122 cites W190565509 @default.
• W2116791122 cites W193039664 @default.
• W2116791122 cites W1966807838 @default.
• W2116791122 cites W1970316977 @default.
• W2116791122 cites W1971891190 @default.
• W2116791122 cites W1973130338 @default.
• W2116791122 cites W1975118530 @default.
• W2116791122 cites W1975653060 @default.
• W2116791122 cites W1976483990 @default.
• W2116791122 cites W1977937217 @default.
• W2116791122 cites W1980077716 @default.
• W2116791122 cites W1982864613 @default.
• W2116791122 cites W1983960346 @default.
• W2116791122 cites W1984634775 @default.
• W2116791122 cites W1986823657 @default.
• W2116791122 cites W1988568604 @default.
• W2116791122 cites W1992486838 @default.
• W2116791122 cites W1995345553 @default.
• W2116791122 cites W1995611237 @default.
• W2116791122 cites W1997598762 @default.
• W2116791122 cites W1998257682 @default.
• W2116791122 cites W2003402040 @default.
• W2116791122 cites W2007889607 @default.
• W2116791122 cites W2007951396 @default.
• W2116791122 cites W2012390284 @default.
• W2116791122 cites W2013882235 @default.
• W2116791122 cites W2017510293 @default.
• W2116791122 cites W2020207011 @default.
• W2116791122 cites W2021013804 @default.
• W2116791122 cites W2022815318 @default.
• W2116791122 cites W2023073151 @default.
• W2116791122 cites W2023503726 @default.
• W2116791122 cites W2023944666 @default.
• W2116791122 cites W2025987186 @default.
• W2116791122 cites W2026929703 @default.
• W2116791122 cites W2026968086 @default.
• W2116791122 cites W2028136556 @default.
• W2116791122 cites W2033061942 @default.
• W2116791122 cites W2033669466 @default.
• W2116791122 cites W2039321614 @default.
• W2116791122 cites W2041481324 @default.
• W2116791122 cites W2042796280 @default.
• W2116791122 cites W2047388403 @default.
• W2116791122 cites W2049056319 @default.
• W2116791122 cites W2049083231 @default.
• W2116791122 cites W2053185422 @default.
• W2116791122 cites W2056811928 @default.
• W2116791122 cites W2064750253 @default.
• W2116791122 cites W2065255945 @default.
• W2116791122 cites W2065834645 @default.
• W2116791122 cites W2069198409 @default.
• W2116791122 cites W2069784262 @default.
• W2116791122 cites W2072681409 @default.
• W2116791122 cites W2073792957 @default.
• W2116791122 cites W2077544247 @default.
• W2116791122 cites W2084400644 @default.
• W2116791122 cites W2084643538 @default.
• W2116791122 cites W2091061257 @default.
• W2116791122 cites W2092696076 @default.
• W2116791122 cites W2095564883 @default.
• W2116791122 cites W2098335716 @default.
• W2116791122 cites W2099064857 @default.
• W2116791122 cites W2102780111 @default.
• W2116791122 cites W2112053394 @default.
• W2116791122 cites W2113407671 @default.
• W2116791122 cites W2116640771 @default.
• W2116791122 cites W2136842360 @default.
• W2116791122 cites W2151108850 @default.
• W2116791122 cites W2157025783 @default.
• W2116791122 cites W2158134272 @default.
• W2116791122 cites W2165468212 @default.
• W2116791122 cites W2165844418 @default.
• W2116791122 cites W2166858759 @default.
• W2116791122 cites W2197774836 @default.
• W2116791122 cites W2247656122 @default.
• W2116791122 cites W2315327352 @default.
• W2116791122 cites W2408980082 @default.
• W2116791122 cites W2435658464 @default.
• W2116791122 cites W3156308640 @default.
• W2116791122 cites W4245890394 @default.
• W2116791122 doi "https://doi.org/10.1517/14656566.2011.589836" @default.
• W2116791122 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21679091" @default.
• W2116791122 hasPublicationYear "2011" @default.
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