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• W2116794457 abstract "The aryl hydrocarbon receptor (AHR) repressor (AHRR) inhibits AHR-mediated transcription and has been associated with reproductive dysfunction and tumorigenesis in humans. Previous studies have characterized the repressor function of AHRRs from mice and fish, but the human AHRR ortholog (AHRR(715)) appeared to be nonfunctional in vitro. Here, we report a novel human AHRR cDNA (AHRRDelta8) that lacks exon 8 of AHRR(715). AHRRDelta8 was the predominant AHRR form expressed in human tissues and cell lines. AHRRDelta8 effectively repressed AHR-dependent transactivation, whereas AHRR(715) was much less active. Similarly, AHRRDelta8, but not AHRR(715), formed a complex with AHR nuclear translocator (ARNT). Repression of AHR by AHRRDelta8 was not relieved by overexpression of ARNT or AHR coactivators, suggesting that competition for these cofactors is not the mechanism of repression. AHRRDelta8 interacted weakly with AHR but did not inhibit its nuclear translocation. In a survey of transcription factor specificity, AHRRDelta8 did not repress the nuclear receptor pregnane X receptor or estrogen receptor alpha but did repress hypoxia-inducible factor (HIF)-dependent signaling. AHRRDelta8-Pro(185) and -Ala(185) variants, which have been linked to human reproductive disorders, both were capable of repressing AHR or HIF. Together, these results identify AHRRDelta8 as the active form of human AHRR and reveal novel aspects of its function and specificity as a repressor." @default.
• W2116794457 created "2016-06-24" @default.
• W2116794457 creator A5004117032 @default.
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• W2116794457 date "2009-07-01" @default.
• W2116794457 modified "2023-09-23" @default.
• W2116794457 title "The Active Form of Human Aryl Hydrocarbon Receptor (AHR) Repressor Lacks Exon 8, and Its Pro¹⁸⁵ and Ala¹⁸⁵ Variants Repress both AHR and Hypoxia-Inducible Factor" @default.
• W2116794457 cites W1905417203 @default.
• W2116794457 cites W1969042227 @default.
• W2116794457 cites W1971296208 @default.
• W2116794457 cites W1974546331 @default.
• W2116794457 cites W1975091600 @default.
• W2116794457 cites W1976750272 @default.
• W2116794457 cites W1979434152 @default.
• W2116794457 cites W1980435646 @default.
• W2116794457 cites W1986806772 @default.
• W2116794457 cites W1994364558 @default.
• W2116794457 cites W1996162026 @default.
• W2116794457 cites W2005706586 @default.
• W2116794457 cites W2006334693 @default.
• W2116794457 cites W2006368030 @default.
• W2116794457 cites W2007601885 @default.
• W2116794457 cites W2011070950 @default.
• W2116794457 cites W2012911863 @default.
• W2116794457 cites W2018712283 @default.
• W2116794457 cites W2019201641 @default.
• W2116794457 cites W2020332744 @default.
• W2116794457 cites W2023259982 @default.
• W2116794457 cites W2032217767 @default.
• W2116794457 cites W2040475011 @default.
• W2116794457 cites W2043093014 @default.
• W2116794457 cites W2043858835 @default.
• W2116794457 cites W2045942064 @default.
• W2116794457 cites W2050572437 @default.
• W2116794457 cites W2056254634 @default.
• W2116794457 cites W2059702269 @default.
• W2116794457 cites W2060113755 @default.
• W2116794457 cites W2065956908 @default.
• W2116794457 cites W2066254714 @default.
• W2116794457 cites W2070254655 @default.
• W2116794457 cites W2070457447 @default.
• W2116794457 cites W2070730833 @default.
• W2116794457 cites W2075903927 @default.
• W2116794457 cites W2079158902 @default.
• W2116794457 cites W2082809617 @default.
• W2116794457 cites W2084585544 @default.
• W2116794457 cites W2085397935 @default.
• W2116794457 cites W2085609942 @default.
• W2116794457 cites W2088348233 @default.
• W2116794457 cites W2089084448 @default.
• W2116794457 cites W2099424722 @default.
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• W2116794457 cites W2107945943 @default.
• W2116794457 cites W2112701873 @default.
• W2116794457 cites W2117949279 @default.
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• W2116794457 cites W2135683331 @default.
• W2116794457 cites W2135984731 @default.
• W2116794457 cites W2138913971 @default.
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• W2116794457 cites W2142013281 @default.
• W2116794457 cites W2143474295 @default.
• W2116794457 cites W2149302625 @default.
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• W2116794457 doi "https://doi.org/10.1128/mcb.00206-09" @default.
• W2116794457 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2698758" @default.
• W2116794457 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19380484" @default.
• W2116794457 hasPublicationYear "2009" @default.
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