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• W2116797609 abstract "A genome-wide association scan of approximately 6.6 million genotyped or imputed variants in 882 Sardinian individuals with multiple sclerosis (cases) and 872 controls suggested association of CBLB gene variants with disease, which was confirmed in 1,775 cases and 2,005 controls (rs9657904, overall P = 1.60 x 10(-10), OR = 1.40). CBLB encodes a negative regulator of adaptive immune responses, and mice lacking the ortholog are prone to experimental autoimmune encephalomyelitis, the animal model of multiple sclerosis." @default.
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• W2116797609 date "2010-05-09" @default.
• W2116797609 modified "2023-10-05" @default.
• W2116797609 title "Variants within the immunoregulatory CBLB gene are associated with multiple sclerosis" @default.
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• W2116797609 doi "https://doi.org/10.1038/ng.584" @default.
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