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• W2116799486 abstract "In animals, microRNAs (miRNAs) bind to the 3′ UTRs of their target mRNAs and interfere with translation, although the exact mechanism of inhibition of protein synthesis remains unclear. Functional miRNA-binding sites in the coding regions or 5′ UTRs of endogenous mRNAs have not been identified. We studied the effect of introducing miRNA target sites into the 5′ UTR of luciferase reporter mRNAs containing internal ribosome entry sites (IRESs), so that potential steric hindrance by a microribonucleoprotein complex would not interfere with the initiation of translation. In human HeLa cells, which express endogenous let-7a miRNA, the translational efficiency of these IRES-containing reporters with 5′ let-7 complementary sites from the Caenorhabditis elegans lin-41 3′ UTR was repressed. Similarly, the IRES-containing reporters were translationally repressed when human Ago2 was tethered to either the 5′ or 3′ UTR. Interestingly, the method of DNA transfection affected our ability to observe miRNA-mediated repression. Our results suggest that association with any position on a target mRNA is mechanistically sufficient for a microribonucleoprotein to exert repression of translation at some step downstream of initiation." @default.
• W2116799486 created "2016-06-24" @default.
• W2116799486 creator A5035064101 @default.
• W2116799486 creator A5042840350 @default.
• W2116799486 creator A5072475872 @default.
• W2116799486 date "2007-06-05" @default.
• W2116799486 modified "2023-10-03" @default.
• W2116799486 title "Target mRNAs are repressed as efficiently by microRNA-binding sites in the 5′ UTR as in the 3′ UTR" @default.
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• W2116799486 doi "https://doi.org/10.1073/pnas.0703820104" @default.
• W2116799486 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1887587" @default.
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• W2116799486 hasPublicationYear "2007" @default.
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