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• W2116812447 abstract "Abstract Herpetic stromal keratitis (HSK), resulting from corneal HSV-1 infection, represents a T cell-mediated immunopathologic lesion. In T cell transgenic mice on a SCID or RAG knockout background, the T cells mediating lesions are unreactive to viral Ags. In these bystander models, animals develop ocular lesions but are unable to control infection. Transfer of HSV-immune cells into a CD8+ T cell bystander model resulted in clearance of virus from eyes, animals survived, and lesions developed to greater severity. However, the adoptively transferred CD8+ T cells were not evident in lesions, although they were readily detectable in the lymphoid tissues as well as in the peripheral and CNS. Our results indicate that viral-induced tissue damage can be caused by bystander cells, but these fail to control infection. Immune CD8+ T cells trigger clearance of virus from the eye, but this appears to result by the T cells acting at sites distal to the cornea. A case is made that CD8+ T cell control is expressed in the trigeminal ganglion, serving to curtail a source of virus to the cornea." @default.
• W2116812447 created "2016-06-24" @default.
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• W2116812447 date "2004-12-15" @default.
• W2116812447 modified "2023-09-27" @default.
• W2116812447 title "Protective and Pathological Roles of Virus-Specific and Bystander CD8+ T Cells in Herpetic Stromal Keratitis" @default.
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• W2116812447 doi "https://doi.org/10.4049/jimmunol.173.12.7575" @default.
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