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- W2116813423 abstract "Recombinant IFN-α (rIFN-α) induces complete hematologic remissions in patients with myeloproliferative neoplasms (MPNs), but its use has been limited by side effects owing to the relatively high doses used. Now, low-dose rIFN-α is stressed, starting relatively early in the course of the MPNs. In polycythemia vera, this has resulted in a significant clinical, hematologic, morphologic and molecular response manifested by reduction in the JAK2V617F allele burden, sustained even after discontinuation of recombinant IFN. In essential thrombocythemia, platelet count reduction is prompt and durable without treatment for varying periods. In hypercellular primary myelofibrosis, rIFN-α has restored normal blood counts, reduced splenomegaly and induced morphologic marrow remissions. This article highlights our current use of rIFN-α in MPNs." @default.
- W2116813423 created "2016-06-24" @default.
- W2116813423 creator A5008609620 @default.
- W2116813423 creator A5040941721 @default.
- W2116813423 creator A5053726532 @default.
- W2116813423 date "2013-02-01" @default.
- W2116813423 modified "2023-09-30" @default.
- W2116813423 title "Interferon and the treatment of polycythemia vera, essential thrombocythemia and myelofibrosis" @default.
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- W2116813423 doi "https://doi.org/10.1586/ehm.12.69" @default.
- W2116813423 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23373780" @default.
- W2116813423 hasPublicationYear "2013" @default.
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