FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2116816109> ?p ?o ?g. }

• W2116816109 endingPage "708" @default.
• W2116816109 startingPage "704" @default.
• W2116816109 abstract "Estrogen regulates thymic development and immune function. Despite the critical role of estrogens in inducing thymic involution and modulating immune responses, the mechanism of this effect is unclear. Similarly, humans and animals are exposed to increasing amounts of the estrogenic soy isoflavone genistein in the diet, but whether genistein can induce immune changes has not been definitively established. We reported previously that genistein induces thymic atrophy in mice, and decreases both humoral and cell-mediated immunity. These thymic effects of genistein occur via estrogen receptor (ER)-mediated and non-ER-mediated pathways. Genistein injections produced the most pronounced effects, but dietary administration to mice that produced serum genistein concentrations similar to those reported in human infants consuming soy formula also had demonstrable effects. Microarray analysis of the effects of estradiol and genistein on neonatal thymus indicated that estradiol affected genes involved in transcription, apoptosis, cell cycle, and thymic development and function; genistein had similar effects on many estradiol target genes, but also had unique actions not replicated by estradiol. Despite extensive work showing inhibitory effects of genistein on immunity, other rodent studies reported that genistein or other phytoestrogens stimulate various aspects of immune function. Although the present data strongly indicate that genistein can regulate immune function, possibly at physiologic concentrations, further work is required to definitively establish overall thymic and immune effects of genistein and soy, which may vary with age, species, and specific end point." @default.
• W2116816109 created "2016-06-24" @default.
• W2116816109 creator A5025927483 @default.
• W2116816109 creator A5064269789 @default.
• W2116816109 creator A5070467153 @default.
• W2116816109 date "2006-03-01" @default.
• W2116816109 modified "2023-10-01" @default.
• W2116816109 title "Genistein, Estrogen Receptors, and the Acquired Immune Response" @default.
• W2116816109 cites W1498384054 @default.
• W2116816109 cites W1937331953 @default.
• W2116816109 cites W1944158606 @default.
• W2116816109 cites W1967731164 @default.
• W2116816109 cites W1968814123 @default.
• W2116816109 cites W2009527950 @default.
• W2116816109 cites W2026189650 @default.
• W2116816109 cites W2027259461 @default.
• W2116816109 cites W2033987141 @default.
• W2116816109 cites W2034359758 @default.
• W2116816109 cites W2043764768 @default.
• W2116816109 cites W2046529862 @default.
• W2116816109 cites W2046698026 @default.
• W2116816109 cites W2046741700 @default.
• W2116816109 cites W2072431465 @default.
• W2116816109 cites W2101468366 @default.
• W2116816109 cites W2111369007 @default.
• W2116816109 cites W2117977971 @default.
• W2116816109 cites W2125689691 @default.
• W2116816109 cites W2131032307 @default.
• W2116816109 cites W2142687587 @default.
• W2116816109 cites W2147157882 @default.
• W2116816109 cites W2148220584 @default.
• W2116816109 cites W2175186734 @default.
• W2116816109 doi "https://doi.org/10.1093/jn/136.3.704" @default.
• W2116816109 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16484547" @default.
• W2116816109 hasPublicationYear "2006" @default.
• W2116816109 type Work @default.
• W2116816109 sameAs 2116816109 @default.
• W2116816109 citedByCount "70" @default.
• W2116816109 countsByYear W21168161092012 @default.
• W2116816109 countsByYear W21168161092013 @default.
• W2116816109 countsByYear W21168161092014 @default.
• W2116816109 countsByYear W21168161092015 @default.
• W2116816109 countsByYear W21168161092016 @default.
• W2116816109 countsByYear W21168161092017 @default.
• W2116816109 countsByYear W21168161092018 @default.
• W2116816109 countsByYear W21168161092020 @default.
• W2116816109 countsByYear W21168161092021 @default.
• W2116816109 countsByYear W21168161092022 @default.
• W2116816109 countsByYear W21168161092023 @default.
• W2116816109 crossrefType "journal-article" @default.
• W2116816109 hasAuthorship W2116816109A5025927483 @default.
• W2116816109 hasAuthorship W2116816109A5064269789 @default.
• W2116816109 hasAuthorship W2116816109A5070467153 @default.
• W2116816109 hasBestOaLocation W21168161091 @default.
• W2116816109 hasConcept C121608353 @default.
• W2116816109 hasConcept C126322002 @default.
• W2116816109 hasConcept C134018914 @default.
• W2116816109 hasConcept C203014093 @default.
• W2116816109 hasConcept C2776090121 @default.
• W2116816109 hasConcept C2777164284 @default.
• W2116816109 hasConcept C2777314012 @default.
• W2116816109 hasConcept C2778270713 @default.
• W2116816109 hasConcept C2778298627 @default.
• W2116816109 hasConcept C530470458 @default.
• W2116816109 hasConcept C71924100 @default.
• W2116816109 hasConcept C84606932 @default.
• W2116816109 hasConcept C86803240 @default.
• W2116816109 hasConcept C8891405 @default.
• W2116816109 hasConceptScore W2116816109C121608353 @default.
• W2116816109 hasConceptScore W2116816109C126322002 @default.
• W2116816109 hasConceptScore W2116816109C134018914 @default.
• W2116816109 hasConceptScore W2116816109C203014093 @default.
• W2116816109 hasConceptScore W2116816109C2776090121 @default.
• W2116816109 hasConceptScore W2116816109C2777164284 @default.
• W2116816109 hasConceptScore W2116816109C2777314012 @default.
• W2116816109 hasConceptScore W2116816109C2778270713 @default.
• W2116816109 hasConceptScore W2116816109C2778298627 @default.
• W2116816109 hasConceptScore W2116816109C530470458 @default.
• W2116816109 hasConceptScore W2116816109C71924100 @default.
• W2116816109 hasConceptScore W2116816109C84606932 @default.
• W2116816109 hasConceptScore W2116816109C86803240 @default.
• W2116816109 hasConceptScore W2116816109C8891405 @default.
• W2116816109 hasIssue "3" @default.
• W2116816109 hasLocation W21168161091 @default.
• W2116816109 hasLocation W21168161092 @default.
• W2116816109 hasOpenAccess W2116816109 @default.
• W2116816109 hasPrimaryLocation W21168161091 @default.
• W2116816109 hasRelatedWork W1964535481 @default.
• W2116816109 hasRelatedWork W2025170339 @default.
• W2116816109 hasRelatedWork W2068408721 @default.
• W2116816109 hasRelatedWork W2093476509 @default.
• W2116816109 hasRelatedWork W2095977507 @default.
• W2116816109 hasRelatedWork W2101821182 @default.
• W2116816109 hasRelatedWork W2116480637 @default.
• W2116816109 hasRelatedWork W2116816109 @default.
• W2116816109 hasRelatedWork W2150216118 @default.
• W2116816109 hasRelatedWork W4232275671 @default.
• W2116816109 hasVolume "136" @default.

• next