FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2116817824> ?p ?o ?g. }

• W2116817824 endingPage "217" @default.
• W2116817824 startingPage "213" @default.
• W2116817824 abstract "ABSTRACT We evaluated the activities of meropenem, imipenem, temocillin, piperacillin, and ceftazidime by determination of the MICs for 66 genotypically characterized Burkholderia cepacia isolates obtained from the sputum of cystic fibrosis patients. In vitro synergy assays, as performed by the time-kill methodology, of two- and three-drug combinations of the β-lactams with tobramycin, rifampin, and/or ciprofloxacin were also performed with 10 strains susceptible, intermediate, or resistant to fluoroquinolones. On the basis of the MICs, meropenem and temocillin were the most active β-lactam agents, with MICs at which 90% of isolates are inhibited of 8 and 32 μg/ml, respectively. The addition of ciprofloxacin significantly enhanced the killing activities of piperacillin, imipenem, and meropenem against the 10 strains tested ( P < 0.05). The best killing activity was obtained with the combination of meropenem and ciprofloxacin, with bactericidal activity of 3.31 ± 0.36 log 10 CFU/ml ( P < 0.05). Compared to the activity of the two-drug β-lactam–ciprofloxacin combination, the addition of rifampin or tobramycin did not significantly increase the killing activity ( P > 0.05). The three-drug combinations (with or without ciprofloxacin) significantly enhanced the killing activities of piperacillin, imipenem, and meropenem relative to the activities of the β-lactams used alone ( P < 0.05). The combination β-lactam–ciprofloxacin–tobramycin was the combination with the most consistently synergistic effect." @default.
• W2116817824 created "2016-06-24" @default.
• W2116817824 creator A5050704067 @default.
• W2116817824 creator A5077828213 @default.
• W2116817824 creator A5081161395 @default.
• W2116817824 creator A5091444788 @default.
• W2116817824 date "1999-02-01" @default.
• W2116817824 modified "2023-10-10" @default.
• W2116817824 title "Comparative In Vitro Activities of Meropenem, Imipenem, Temocillin, Piperacillin, and Ceftazidime in Combination with Tobramycin, Rifampin, or Ciprofloxacin against Burkholderia cepacia Isolates from Patients with Cystic Fibrosis" @default.
• W2116817824 cites W1499247383 @default.
• W2116817824 cites W1885926470 @default.
• W2116817824 cites W1981123754 @default.
• W2116817824 cites W1996891047 @default.
• W2116817824 cites W2006894520 @default.
• W2116817824 cites W2027014550 @default.
• W2116817824 cites W2034483565 @default.
• W2116817824 cites W2035663207 @default.
• W2116817824 cites W2038094619 @default.
• W2116817824 cites W2039385490 @default.
• W2116817824 cites W2040862133 @default.
• W2116817824 cites W2043457391 @default.
• W2116817824 cites W2055698029 @default.
• W2116817824 cites W2058161327 @default.
• W2116817824 cites W2077080558 @default.
• W2116817824 cites W2077258216 @default.
• W2116817824 cites W2080175002 @default.
• W2116817824 cites W2080571234 @default.
• W2116817824 cites W2097201894 @default.
• W2116817824 cites W2097392857 @default.
• W2116817824 cites W2110219060 @default.
• W2116817824 cites W2115886814 @default.
• W2116817824 cites W2115960722 @default.
• W2116817824 cites W2118192507 @default.
• W2116817824 cites W2122648848 @default.
• W2116817824 cites W2125131865 @default.
• W2116817824 cites W2126610596 @default.
• W2116817824 cites W2131282863 @default.
• W2116817824 cites W2155199677 @default.
• W2116817824 cites W2156810726 @default.
• W2116817824 cites W2163773920 @default.
• W2116817824 cites W2165415752 @default.
• W2116817824 cites W2167337398 @default.
• W2116817824 cites W2167588580 @default.
• W2116817824 cites W2167709283 @default.
• W2116817824 cites W2170171231 @default.
• W2116817824 cites W2171862804 @default.
• W2116817824 cites W2172247411 @default.
• W2116817824 cites W2439503167 @default.
• W2116817824 doi "https://doi.org/10.1128/aac.43.2.213" @default.
• W2116817824 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/89053" @default.
• W2116817824 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9925508" @default.
• W2116817824 hasPublicationYear "1999" @default.
• W2116817824 type Work @default.
• W2116817824 sameAs 2116817824 @default.
• W2116817824 citedByCount "58" @default.
• W2116817824 countsByYear W21168178242012 @default.
• W2116817824 countsByYear W21168178242013 @default.
• W2116817824 countsByYear W21168178242014 @default.
• W2116817824 countsByYear W21168178242015 @default.
• W2116817824 countsByYear W21168178242017 @default.
• W2116817824 countsByYear W21168178242018 @default.
• W2116817824 countsByYear W21168178242019 @default.
• W2116817824 countsByYear W21168178242020 @default.
• W2116817824 countsByYear W21168178242023 @default.
• W2116817824 crossrefType "journal-article" @default.
• W2116817824 hasAuthorship W2116817824A5050704067 @default.
• W2116817824 hasAuthorship W2116817824A5077828213 @default.
• W2116817824 hasAuthorship W2116817824A5081161395 @default.
• W2116817824 hasAuthorship W2116817824A5091444788 @default.
• W2116817824 hasBestOaLocation W21168178241 @default.
• W2116817824 hasConcept C2775832221 @default.
• W2116817824 hasConcept C2776968632 @default.
• W2116817824 hasConcept C2777637488 @default.
• W2116817824 hasConcept C2778193466 @default.
• W2116817824 hasConcept C2778512257 @default.
• W2116817824 hasConcept C2778974779 @default.
• W2116817824 hasConcept C2779375183 @default.
• W2116817824 hasConcept C2779631663 @default.
• W2116817824 hasConcept C2780855054 @default.
• W2116817824 hasConcept C3019249092 @default.
• W2116817824 hasConcept C501593827 @default.
• W2116817824 hasConcept C523546767 @default.
• W2116817824 hasConcept C54355233 @default.
• W2116817824 hasConcept C71924100 @default.
• W2116817824 hasConcept C86803240 @default.
• W2116817824 hasConcept C89423630 @default.
• W2116817824 hasConcept C94665300 @default.
• W2116817824 hasConcept C98274493 @default.
• W2116817824 hasConceptScore W2116817824C2775832221 @default.
• W2116817824 hasConceptScore W2116817824C2776968632 @default.
• W2116817824 hasConceptScore W2116817824C2777637488 @default.
• W2116817824 hasConceptScore W2116817824C2778193466 @default.
• W2116817824 hasConceptScore W2116817824C2778512257 @default.
• W2116817824 hasConceptScore W2116817824C2778974779 @default.
• W2116817824 hasConceptScore W2116817824C2779375183 @default.
• W2116817824 hasConceptScore W2116817824C2779631663 @default.
• W2116817824 hasConceptScore W2116817824C2780855054 @default.
• W2116817824 hasConceptScore W2116817824C3019249092 @default.

• next