FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2116822712> ?p ?o ?g. }

• W2116822712 endingPage "76" @default.
• W2116822712 startingPage "67" @default.
• W2116822712 abstract "Background The World Health Organization (WHO) recommends praziquantel for the control and treatment of schistosomiasis, with no real alternative. Pre-school children are excluded from population treatment programs mainly due to paucity of safety data on this age group. Objectives: This study investigated safety, efficacy and acceptability of praziquantel for the treatment of S. haematobium and S. mansoni infections among pre-school children aged <6years. The study also investigated the burden of schistosomiasis in this age group. Methods: Pre-school children (n=188) from Sudan were included in the study. The children were treated with praziquantel tablets at a single dose of 40 mg/kg body weight. Adverse events were assessed at 24 hours and 7 days later, via questionnaire administration to parents and guardians. Efficacy of treatment was assessed at 1, 3 and 6 months by examining stool and urine samples for schistosome eggs. Acceptability was determined by the number of children spitting or vomiting during administration of the drug. Results: The burden of schistosomiasis among pre-school children aged <6 years was high (31.1%), and this was comparable to that observed among school children-aged �6 years (32%). Praziquantel treatment achieved high cure rates (egg negative) for both S. haematobium and S. mansoni infections when assessed at 1 month after treatment (89.6-92.1%) and remained high for S. haematobium (89.6-100%) up to 6 months. However, cure rate dropped from 90.5% at one month to 58.8% and 69.2% at 3 and 6 months among S. mansoni -treated children. Praziquantel treatment decreased egg counts considerably with post-treatment geometric mean egg reductions rates ranging from 96.4% to 99.4% at 1 month. Acceptability of praziquantel treatment was high, only for one child the dose had to be repeated after initial spitting. Treatment resolved haematuria and improved weight of the children. There were no drug-related adverse events in all the treated children during follow-up at 24 hours and 7 days. Conclusions: Praziquantel is safe, effective and acceptable among children aged <6 years. Preschool children represent a high risk group for schistosomiasis and should be included in population treatment programs." @default.
• W2116822712 created "2016-06-24" @default.
• W2116822712 creator A5009189861 @default.
• W2116822712 creator A5023185793 @default.
• W2116822712 creator A5024615584 @default.
• W2116822712 creator A5032174244 @default.
• W2116822712 creator A5040833365 @default.
• W2116822712 creator A5050312610 @default.
• W2116822712 creator A5070954843 @default.
• W2116822712 creator A5081472807 @default.
• W2116822712 creator A5086768344 @default.
• W2116822712 date "2012-01-01" @default.
• W2116822712 modified "2023-09-23" @default.
• W2116822712 title "Treatment of pre-school children under 6 years of age for schistosomiasis: safety, efficacy and acceptability of praziquantel" @default.
• W2116822712 cites W1263782925 @default.
• W2116822712 cites W1561881988 @default.
• W2116822712 cites W1594084749 @default.
• W2116822712 cites W1643526650 @default.
• W2116822712 cites W1655836331 @default.
• W2116822712 cites W193754951 @default.
• W2116822712 cites W1969461065 @default.
• W2116822712 cites W1975186946 @default.
• W2116822712 cites W1990861050 @default.
• W2116822712 cites W1992064195 @default.
• W2116822712 cites W1996354214 @default.
• W2116822712 cites W2005980437 @default.
• W2116822712 cites W2011671647 @default.
• W2116822712 cites W2016150993 @default.
• W2116822712 cites W2021217681 @default.
• W2116822712 cites W2023374722 @default.
• W2116822712 cites W2029239193 @default.
• W2116822712 cites W2036242422 @default.
• W2116822712 cites W2047711974 @default.
• W2116822712 cites W2053169582 @default.
• W2116822712 cites W2055312895 @default.
• W2116822712 cites W2062921719 @default.
• W2116822712 cites W2067454999 @default.
• W2116822712 cites W2073958390 @default.
• W2116822712 cites W2074123426 @default.
• W2116822712 cites W2075150529 @default.
• W2116822712 cites W2089465395 @default.
• W2116822712 cites W2094315264 @default.
• W2116822712 cites W2100629206 @default.
• W2116822712 cites W2107564761 @default.
• W2116822712 cites W2130758584 @default.
• W2116822712 cites W2131747268 @default.
• W2116822712 cites W2144059865 @default.
• W2116822712 cites W2146741195 @default.
• W2116822712 cites W2149424590 @default.
• W2116822712 cites W2158723210 @default.
• W2116822712 cites W2169306519 @default.
• W2116822712 cites W2334703999 @default.
• W2116822712 cites W2412196667 @default.
• W2116822712 cites W2011174129 @default.
• W2116822712 hasPublicationYear "2012" @default.
• W2116822712 type Work @default.
• W2116822712 sameAs 2116822712 @default.
• W2116822712 citedByCount "1" @default.
• W2116822712 countsByYear W21168227122012 @default.
• W2116822712 crossrefType "journal-article" @default.
• W2116822712 hasAuthorship W2116822712A5009189861 @default.
• W2116822712 hasAuthorship W2116822712A5023185793 @default.
• W2116822712 hasAuthorship W2116822712A5024615584 @default.
• W2116822712 hasAuthorship W2116822712A5032174244 @default.
• W2116822712 hasAuthorship W2116822712A5040833365 @default.
• W2116822712 hasAuthorship W2116822712A5050312610 @default.
• W2116822712 hasAuthorship W2116822712A5070954843 @default.
• W2116822712 hasAuthorship W2116822712A5081472807 @default.
• W2116822712 hasAuthorship W2116822712A5086768344 @default.
• W2116822712 hasConcept C126322002 @default.
• W2116822712 hasConcept C165901193 @default.
• W2116822712 hasConcept C187212893 @default.
• W2116822712 hasConcept C197934379 @default.
• W2116822712 hasConcept C203014093 @default.
• W2116822712 hasConcept C2776225656 @default.
• W2116822712 hasConcept C2777445151 @default.
• W2116822712 hasConcept C2779744950 @default.
• W2116822712 hasConcept C2780852908 @default.
• W2116822712 hasConcept C2908647359 @default.
• W2116822712 hasConcept C71924100 @default.
• W2116822712 hasConcept C99454951 @default.
• W2116822712 hasConceptScore W2116822712C126322002 @default.
• W2116822712 hasConceptScore W2116822712C165901193 @default.
• W2116822712 hasConceptScore W2116822712C187212893 @default.
• W2116822712 hasConceptScore W2116822712C197934379 @default.
• W2116822712 hasConceptScore W2116822712C203014093 @default.
• W2116822712 hasConceptScore W2116822712C2776225656 @default.
• W2116822712 hasConceptScore W2116822712C2777445151 @default.
• W2116822712 hasConceptScore W2116822712C2779744950 @default.
• W2116822712 hasConceptScore W2116822712C2780852908 @default.
• W2116822712 hasConceptScore W2116822712C2908647359 @default.
• W2116822712 hasConceptScore W2116822712C71924100 @default.
• W2116822712 hasConceptScore W2116822712C99454951 @default.
• W2116822712 hasIssue "2" @default.
• W2116822712 hasLocation W21168227121 @default.
• W2116822712 hasOpenAccess W2116822712 @default.
• W2116822712 hasPrimaryLocation W21168227121 @default.
• W2116822712 hasRelatedWork W1975186946 @default.

• next